Abstract
The effect of a pineal gland polypeptide complex, Pineamin, on urine excretion of 6-sulfatoxymelatonin (6-SOMT) was investigated by immunoenzyme assay in 55 elderly patients with decreased melatonin formation. Pineamin at a dose of 100 mg increased the level of 6-SOMT excretion in overnight urine by 1.9 times in comparison with the respective indicator before the treatment. A similar effect was previously obtained upon the administration of Epitalamin, which also facilitated the restoration of melatonin synthesis in human and animal pineal glands affected by aging. Hence, Pineamin and Epitalamin exhibit a one-directional stimulating property with respect to the melatonin-forming function of the pineal gland in elderly people.
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References
Bondarenko, L.A., Seasonal features of the effect of epithalamin on the development of the night maximum of melatonin in old rats, Probl. Stareniya Dolgoletiya, 1993, vol. 3, no. 2, pp. 97–100.
Goncharova, N.D., Khavinson, V.Kh., and Lapin, B.A., Pineal’naya zheleza i vozrastnaya patologiya (mekhanizmy i korrektsiya) (Pineal Gland and Age-Related Pathology: Mechanisms and Correction), St. Petersburg: Nauka, 2007.
Ermachenkov, M.N., Gulyaev, A.V., Arutyunyan, A.V., Milyutina, Yu.P., and Anisimov, V.N., Age-related changes in 6-hydroxymelatonin sulfate excretion in patients with gastric and colorectal cancer, Adv. Gerontol., 2013, vol. 3, no. 2, pp. 148–153.
Kvetnaia, T.V., Knyaz’kin, I.V., and Kvetnoi, I.M., Melatonin-neiroimmunoendokrinnyi marker vozrastnoi patologii (Melatonin as the Neuroimmune Endocrine Marker of Age-Related Pathology), St. Petersburg: DEAN, 2005.
Korkushko, O.V., Lapin, B.A., Goncharova, N.D., et al., Normalizing effect of epiphysis peptides on the daily content of melatonin in old monkeys and elderly people, Usp. Gerontol., 2007, vol. 20, no. 1, pp. 74–85.
Korkushko, O.V., Khavinson, V.Kh., Butenko, G.M., et al., Peptidnye preparaty timusa i epifiza v profilaktike uskorennogo stareniya (Use of Peptide Thymic and Epiphysis Preparations for Prevention of Accelerated Aging), St. Petersburg: Nauka, 2002.
Korkushko, O.V., Khavinson, V.Kh., Shatilo, V.B., Pineal’naya zheleza: puti korrektsii pri starenii (Pineal Gland: Correction in Aging), St. Petersburg: Nauka, 2006.
Korkushko, O.V., Khavinson, V.Kh., Shatilo, V.B., et al., Geroprotective effect of peptide preparation of the epiphysis in elderly patients with chronic heart ischemia: the results of longitudinal observation, Probl. Stareniya Dolgoletiya, 2012, vol. 1, no. 3, pp. 347–356.
Korkushko, O.V., Shatilo, V.B., Antonyuk-Shcheglova, I.A., et al., Effect of the course of peptide preparations of the epiphysis on the daily concentration of melatonin in blood plasma of elderly people, Bukovin. Med. Visn., 2006, vol. 10, no. 4, pp. 76–79.
Prilepskaya, V.N., Bogatova, I.K., and Radzinskii, V.E., Advances in prevention and therapy of climacteric syndrome, Ginekologiya, 2016, vol. 18, no. 1, pp. 7–12.
Trofimova, S.V., Gorbunov, A.V., and Pronyaeva, V.E., The role of melatonin in the development of retinal pathology in patients of the older age group, Usp. Gerontol., 2012, vol. 25, no. 2, pp. 239–243.
Khavinson, V.Kh., Kuznik, B.I., and Ryzhak, G.A., Peptidnye geroprotektory—epigeneticheskie regulyatory fiziologicheskikh funktsii organizma (Peptide Geroprotectors: Epigenetic Regulators of Physiological Function of Organism), St. Petersburg: Ross. Gos. Pedagog. Univ. im. A.I. Gertsena, 2014.
Khavinson, V.Kh. and Linkova, N.S., Morphofunctional and molecular bases of pineal gland aging, Hum. Physiol., 2012, vol. 38, no. 1, pp. 101–107.
Khavinson, V.Kh., Linkova, N.S., Kvetnoy, I.M., Kvetnaia, T.V., Polyakova, V.O., and Korf, H.-W., Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture, Bull. Exp. Biol. Med., 2012, vol. 153, no. 2, pp. 255–258.
Tsfasman, A.Z. Melatonin: normativy pri razlichnykh sutochnykh rezhimakh. Professional’nye aspekty v patologii (Melatonin: Norms at Different Diurnal Regimes. Professional Aspects in Pathology), Moscow: Mosk. Gos. Univ. Putei Soobshch., 2015.
Tsfasman, A.Z., Gorokhov, V.D., and Alpaev, D.V., The daily content of melatonin during night sleep deprivation, Probl. Endokrinol., 2013, no. 2, pp. 40–44.
Andersen, L.P., Gögenur, I., Rosenberg, J., et al., Pharmacokinetics of melatonin: the missing link in clinical efficacy?, Clin. Pharmacokinet., 2016, vol. 55, no. 9, pp. 1027–1030.
Andersen, L.P., Gögenur, I., Rosenberg, J., et al., The safety of melatonin in humans, Clin. Drug Invest., 2016, vol. 36, no. 3, pp. 169–175.
Anisimov, V.N., Arutjunyan, A.V., and Khavinson, V.Kh., Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals, Neuroendocrinol. Lett., 2001, vol. 22, no. 1, pp. 9–18.
Anisimov, V.N. and Khavinson, V.Kh., Peptide bioregulation of aging: results and prospects, Biogerontology, 2010, vol. 11, no. 2, pp. 139–149.
Khavinson, V.Kh., Peptides and ageing, Neuroendocrinol. Lett., 2002, vol. 23, no. 3, pp. 1–144.
Korkushko, O.V., Khavinson, V.Kh., Shatilo, V.B., et al., Peptide geroprotector from the pineal gland inhibits rapid aging of elderly people: results of 15-year follow-up, Bull. Exp. Biol. Med., 2011, vol. 151, no. 3, pp. 366–369.
Pierpaoli, W. and Maestroni, G.J.M., Melatonin: a principal neuroimmunoendocrinology and anti-stress hormone: its anti-aging effect, Immunol. Lett., 1987, vol. 16, pp. 355–362.
Sánchez-Barceló, E.J., Mediavilla, M.D., Tan, D.X., et al., Clinical uses of melatonin: evaluation of human trials, Curr. Med. Chem., 2010, vol. 17, no. 19, pp. 2070–2095.
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Trofimova, S.V., Linkova, N.S., Klimenko, A.A. et al. Pineamin Increases Melatonin Synthesis in Pineal Gland of Elderly People. Adv Gerontol 7, 319–322 (2017). https://doi.org/10.1134/S2079057017040130
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DOI: https://doi.org/10.1134/S2079057017040130