Abstract
The frequency distribution of alleles and genotypes of the single nucleotide substitution G13494A in intron 6 and the duplication dup16bp in intron 3 of the gene TP53 in 56 patients with indolent variants of non-Hodgkin lymphoma and in the control group was studied. An increase in the frequency of the G-allele and G/G genotype of intron 6 of the gene TP53 among elderly patients having lymphomas compared to the control group was observed (91 and 84% vs. 79 (p < 0.01) and 63% (p < 0.01), respectively). It was found that individuals carrying the rare A-allele (i.e., having A/G or A/A genotype) have a risk of the disease 3.23 times (OR = 3.23; [95% CI 1.50; 6.92], p < 0.05) higher than that among the total population. No significant differences were found between the groups in the distribution of the alleles and genotypes of the dup16bp of intron 3 of the TP53 gene. The obtained results indicate that the oligonucleotide substitution G13494A in intron 6 of the proapoptotic gene TP53 in elderly individuals might have a modulating effect on the risk of development of indolent lymphomas.
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Original Russian Text © E.N. Voropaeva, M.I. Voevoda, T.I. Pospelova, V.N. Maksimov, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 2, pp. 258–262.
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Voropaeva, E.N., Voevoda, M.I., Pospelova, T.I. et al. Intronic polymorphisms of antionkogene TP53 in patients with indolent variants of non-Hodgkin lymphomas. Adv Gerontol 4, 42–45 (2014). https://doi.org/10.1134/S2079057014010135
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DOI: https://doi.org/10.1134/S2079057014010135