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Association of polymorphic markers of CASP8, BCL2, and BAX genes with aging and longevity

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Abstract

We have analyzed the genotype frequency dynamics of CASP8, BCL2 and BAX gene polymorphic markers in a group of ethnic Tatars from Bashkortostan aged 21–109 years. Genotyping was carried out using PCR and PCR-RFLP. We have revealed the associations between age and −652(6N)I/D polymorphism of the CASP8 gene (rs3834129), 140016C>T polymorphism of the BCL2 gene (rs12454712), and 919A>G polymorphism of the BAX gene (rs1805419). An increase in the frequency of *C/*C-genotype in BCL2 gene, and a decrease in the frequency of the *I/*D-genotype of CASP8 gene was observed in males of advanced old age. As well as a decreased frequency of *G/*G-genotype of BAX gene among long livers was detected. Females long livers were characterized by an increased number of *I/*D-genotypes of CASP8 gene, *T/*T-genotype of BCL2 gene, and *A/*A-genotype of BAX gene, while the frequency of *D/*D-genotype carriers of CASP8 gene, *C/*C-genotype carriers of BCL2 gene, *A/*G and *G/*G-genotype carriers of BAX gene was reduced.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabra 71, Ufa, 450054, Russia

    V. V. Erdman, T. R. Nasibullin, I. A. Tuktarova & O. E. Mustafina

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  1. V. V. Erdman
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  2. T. R. Nasibullin
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  3. I. A. Tuktarova
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  4. O. E. Mustafina
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Correspondence to V. V. Erdman.

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Original Russian Text © V.V. Erdman, T.R. Nasibullin, I.A. Tuktarova, O.E. Mustafina, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 3, pp. 398–404.

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Erdman, V.V., Nasibullin, T.R., Tuktarova, I.A. et al. Association of polymorphic markers of CASP8, BCL2, and BAX genes with aging and longevity. Adv Gerontol 3, 93–99 (2013). https://doi.org/10.1134/S2079057013020057

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  • DOI: https://doi.org/10.1134/S2079057013020057

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