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Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity

  • HUMAN GENETICS
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Abstract

The aim of this study was to investigate the associations between the polymorphic loci in the JAK/STAT signaling pathway and the aging processes and longevity in the populations of ethnic Tatars. For this aim, we analyzed the age dynamics of genotype frequencies of the JAK1 (32454C>T, rs310216), JAK3 (14385C>T, rs3212780), STAT1 (14228A>C, rs12693591), STAT3 (19006G>C, rs2293152), and STAT5A (1985T>C, rs9889323) genes. Using logistic regression analysis, we discovered the association of these polymorphic loci with advanced age. In the general study group, the probability of the JAK1*C/*Т genotype was higher among persons of advanced age (69–80 years old, p = 0.031, OR = 1.070). In turn, the chance to reach advanced age was lower among the carriers of the JAK1*Т/*Т (58–82 years old, p = 0.014, OR = 0.958) and STAT5A*T/*T (46–109 years old, p < 0.001, OR = 0.979) genotypes. The probability of attaining longevity was higher among men with the STAT3*С/*С genotype (25–98 years old, p = 0.027, OR = 1.016) and was lower among men with the STAT3*G/*С genotype (73–98 years old, p = 0.044, OR = 0.950). In the group of women, the probability to reach 80 years of age and over was higher among carriers of the JAK3*Т/*С (48–81 years old, p = 0.046, OR = 1.024), STAT1*С/*A (61–88 years old, p = 0.041, OR = 1.035), and STAT5A*T/*C (46–82 years old, p < 0.0001, OR = 1.044) genotypes. In turn, among middle age women with the STAT1*С/*С genotype, the probability to attain longevity was lower (55–109 years old, p = 0.013, OR = 0.980).

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ACKNOWLEDGMENTS

The study was carried out using equipment of the Biomika Collective Scientific Center (Department of Biochemical Research and Nanobiotechnology of the RSCP Agidel) and UNU KODINK.

Funding

This manuscript was prepared on the basis of the results of research conducted within the framework of the Russian Federation state contract (state registration number АААА-А16-116020350032-1) and with financial support of the Russian Foundation for Basic Research (grant no. 17-44-020735_r_povolzh’e_а).

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  1. Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    V. V. Erdman, T. R. Nasibullin, I. A. Tuktarova, R. Sh. Somova & O. E. Mustafina

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  1. V. V. Erdman
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  2. T. R. Nasibullin
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by I. Grishina

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Erdman, V.V., Nasibullin, T.R., Tuktarova, I.A. et al. Association Analysis of Polymorphic Gene Variants in the JAK/STAT Signaling Pathway with Aging and Longevity. Russ J Genet 55, 728–737 (2019). https://doi.org/10.1134/S1022795419050077

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