Abstract
The use of immunohistochemical method enabled us to obtain for the first time expression enzymes of extracellular matrix metalloproteinases (MMPs) 2 and 9 in human thymus. Expression of matrix MMPs is decreased in the thymus of old age people in comparison with middle-aged people. These data testified to the important role of MMP2 and MMP9 in extracellular interactions and proliferation activity in thymus aging.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kvetnoi, I.M., Yuzhakov, V.V., Polyakova, V.O., et al., Neuroimmunoendocrine Mechanisms of Proliferative Activity Regulation of Thymocytes in Postnatal Ontogenesis, Med. Zkad. Zhurn., 2004, vol. 47, no. 4, pp. 52–58.
Polyakova, V.O., Expression of Serotonin and Endotelin-1 in Human Thymus during Senescence, Uspekhi Gerontol., 2007, vol. 20, no. 1, pp. 47–51.
Polyakova, V.O., Knyaz’kin, I.V., Konovalov, S.S., et al., Effects of Melatonin Action on Senescence of Thymus Cells and Peripheral T-Lymphocytes in Vitro, Uspekhi Gerontol., 2005, issue 17, pp. 10–14.
Fedoraova, E.S., Polyakova, V.O., Konovalov, S.S., and Kvetnoi, I.M., Expression of Serotonin and Vessels Growth Factor (VEGF) in Human Thymus at Age Involution, Uspekhi Gerontol., 2009, vol. 22, no. 1, pp. 167–171.
Khavinson, B.Kh. and Morozov, V.G., Peptidy epifiza i timusa v regulyatsii stareniya (Peptides of Epiphysis and Thymus in Senescence Regulation), St. Petersburg: Foliant, 2001.
Anisimov, V.N. and Khavinson, V.Kh., Peptide Bioregulation of Aging: Results and Prospects, Biogerontology, 2010, vol. 11, pp. 139–149.
Benson, H. L., Mobashery, S., Chang, M., et al., Endogenous MMP2 and MMP9 Regulate Activation of CD4+ and CD8+ Cells, Amer. J. Resp. Cell Mol. Biol., 2010, vol. 13, pp. 138–146.
Diamantopoulos, N., Boutis, A.L., Kortzis, I., et al., Matrix Metalloproteinases and Proangiogenie Factors in Testicular Germ Cell Tumors, J. Bion., 2010, vol. 15, pp. 116–121.
Garavello, W., Magigioni, D., Nieoloni, C., et al., Association between Metalloproteinases 2 and 9 Activity and ERK Phosphorylation Status in Head Neck Cancer: On ex Vivo Study, Oncol. Rep., 2010, vol. 24, no. 4, pp. 1073–1078.
Lausch, E., Keppler, R., Hilbert, K., et al., Mutations in MMP9 and MMP13 Determine the Mode of Inheritance and the Clinical Spectrum of Metaphyseal Anadysplasia, Amer. J. Hum. Genet., 2009, vol. 85, pp. 168–178.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © N.S. Lin’kova, V.O. Polyakova, I.M. Kvetnoi, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 2, pp. 216–219.
Rights and permissions
About this article
Cite this article
Lin’kova, N.S., Polyakova, V.O. & Kvetnoi, I.M. The role of matrix metalloproteinases in human thymus aging. Adv Gerontol 2, 35–37 (2012). https://doi.org/10.1134/S2079057012010080
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079057012010080