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Structure Formation during Phase Separation of Poly(D,L-Lactide)–Tetraglycol–Antisolvent Ternary System

  • NEW METHODS OF TREATMENT AND PRODUCTION OF MATERIALS WITH REQUIRED PROPERTIES
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Inorganic Materials: Applied Research Aims and scope

Abstract

The diffusion and structure formation processes during phase separation of poly(D,L)-lactide solutions in tetraglycol and their antisolvent deposition in aqueous medium are experimentally studied. The effect of the molecular weight of polymers, the initial concentrations of their solutions, and the composition of antisolvent medium on the type of structures formed is studied. We find that either fractal-like or spongy polymer structures are formed as a result of phase separation processes. We show that the structure type depends on the intensity of diffusion processes in the polylactide–tetraglycol–antisolvent ternary system.

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REFERENCES

  1. Martina, M. and Hutmacher, D.W., Biodegradable polymers applied in tissue engineering research: a review, Polym. Int., 2007, vol. 56, no. 2, pp. 145–157.

    Article  CAS  Google Scholar 

  2. Papkov, S.P., Fiziko-khimicheskie osnovy pererabotki rastvorov polimerov (Physico-Chemical Basis for Processing of Polymer Solutions), Moscow: Khimiya, 1971.

  3. Vlasov, S.V., Kandyrin, L.B., and Kuleznev, V.N., Osnovy tekhnologii pererabotki plastmass (The Technology of Plastics Processing), Moscow: Khimiya, 2004.

  4. Processing of Thermoplastic Materials, Bernhardt, E.C., Ed., New York: Van Nostrand Reinhold, 1959.

    Google Scholar 

  5. Notman, R., den Otter, W.K., Noro, M.G., Briels, W.J., and Anwar, J., The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics, Biophys. J., 2007, vol. 93, no. 6, pp. 2056–2068.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Orlova, O.V., Egorova, S.N., and Oslopov, V.N., The influence of dimethylsulfoxide on the permeability of cell membranes, Kazan. Med. Zh., 2011, vol. 92, no. 6, pp. 901–904.

    Google Scholar 

  7. Li, S., Molina, I., Martinez, M.B., and Vert, M., Hydrolytic and enzymatic degradations of physically crosslinked hydrogels prepared from PLA/PEO/PLA triblock copolymers, J. Mater. Sci.: Mater. Med., 2002, vol. 13, pp. 81–86.

    CAS  Google Scholar 

  8. Krebs, M.D., Sutter, K.A., Lin, A.S.P., Guldberg, R.E., and Alsberg, E., Injectable poly(lactic-co-glycolic) acid scaffolds with in situ pore formation for tissue engineering, Acta Biomater., 2009, vol. 5, no. 8, pp. 2847–2859.

    Article  CAS  PubMed  Google Scholar 

  9. Byun, J.H., Lee, H.A., Kim, T.H., Lee, J.H., and Oh, S.H., Effect of porous polycaprolactone beads on bone regeneration: preliminary in vitro and in vivo studies, Biomater. Res., 2014, vol. 18, p. 18. https://doi.org/10.1186/2055-7124-18-18.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Injectable Biomaterials: Science and Applications, Vernon, B., Ed., Oxford: Woodhead, 2011.

    Google Scholar 

  11. Eliaz, R.E. and Kost, J., Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins, J. Biomed. Mater. Res., 2000, vol. 50, pp. 388–395.

    Article  CAS  PubMed  Google Scholar 

  12. Oh, S.E., Lee, J.Y. Ghil, S.H., Lee, S.S., Yuk, S.H., and Lee, J.H., PCL microparticle-dispersed PLGA solution as a potential injectable urethral bulking agent, Biomaterials, 2006, vol. 27, pp. 1936–1944.

    Article  CAS  PubMed  Google Scholar 

  13. Kim, B.K., Kim, D., Cho, S.H., and Yuk, S.H., Hydrophilized poly(lactide-co-glycolide) nanospheres with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, J. Microencapsulation, 2004, vol. 21, pp. 697–707.

    Article  CAS  PubMed  Google Scholar 

  14. Wang, X.H., Mäkitie, A.A., Paloheimo, K., Tuomi, J., Paloheimo, M., and Sui, S., A tubular PLGA-sandwiched cell/hydrogel fabrication technique based on a step-by-step mold/extraction process, Adv. Polym. Technol., 2011, vol. 30, pp. 163–173.

    Article  CAS  Google Scholar 

  15. Wang, X.H., Sui, S.C., and Liu, C., Optimizing the step-by-step forming processes for fabricating a poly(DL-lactic-co-glycolic acid)-sandwiched cell/ hydrogel construct, J. Appl. Polym. Sci., 2011, vol. 120, pp. 1199–1207.

    Article  CAS  Google Scholar 

  16. Wang, X.H. and Sui, S.C., Pulsatile culture of a poly(DL-lactic-co-glycolic acid) sandwiched cell/ hydrogel construct fabricated using a step-by-step mold/extraction method, Artif. Organs, 2011, vol. 35, pp. 1525–1594.

    Article  CAS  Google Scholar 

  17. Avdeev, M.V., Konovalov, A.N., Bagratashvili, V.N., Popov, V.K., Tsypina, S.I., Sokolova, M., Ke, J., and Poliakoff, M., The fibre optic reflectometer: A new and simple probe for refractive index and phase separation measurements in gases, liquids and supercritical fluids, Phys. Chem. Chem. Phys., 2004, no. 6, pp. 1258–1263.

  18. Mironov, A.V., Grigoryev, A.M., Krotova, L.I., Skaletsky, N.N., Popov, V.K., and Sevastianov, V.I., 3D printing of PLGA scaffolds for tissue engineering, J. Biomed. Mater. Res. A, 2017, vol. 105, pp. 104–109.

    Article  CAS  PubMed  Google Scholar 

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ACKNOWLEDGMENTS

We are grateful to senior researcher A.N. Konovalov (Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics, Russian Academy of Sciences) for his advice and assistance in optical densitometry measurements.

FUNDING

This work was supported by the Russian Ministry of Science and Higher Education as a part of the state task for the Federal Research Center Crystallography and Photonics (Russian Academy of Sciences) in the study of rheological properties of compositions and by the Russian Science Foundation (Russian Foundation for Basic Research project no. 16-29-11722) in the study of structure formation and diffusion processes.

CONFLICT OF INTERESTS

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Institute of Photonic Technologies, Federal Research Center Crystallography and Photonics, Russian Academy of Sciences, 108840, Moscow, Troitsk, Russia

    A. V. Mironov, A. O. Mariyanats, O. A. Mironova & V. K. Popov

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  1. A. V. Mironov
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  2. A. O. Mariyanats
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  3. O. A. Mironova
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  4. V. K. Popov
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Correspondence to A. V. Mironov, A. O. Mariyanats, O. A. Mironova or V. K. Popov.

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Translated by A. Tulyabaev

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Mironov, A.V., Mariyanats, A.O., Mironova, O.A. et al. Structure Formation during Phase Separation of Poly(D,L-Lactide)–Tetraglycol–Antisolvent Ternary System. Inorg. Mater. Appl. Res. 10, 730–736 (2019). https://doi.org/10.1134/S2075113319030274

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  • DOI: https://doi.org/10.1134/S2075113319030274

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