Abstract
We consider an initial-boundary value problem for the system of partial differential equations describing processes of growth and spread of substance in biology, sociology, economics and linguistics. We note from a general point of view that adding diffusion (migration) terms to ordinary differential equations, for example, to logistic ones, can in some cases improve sufficient conditions for the stability of a stationary solution. We give examples of models in which the addition of diffusion terms to ordinary differential equations changes the stability conditions of a stationary solution.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
1 INTRODUCTION
In this paper we study the stability of stationary solutions to differential equations and systems of partial differential equations that arise most often in mathematical biology when describing the quantitative growth and distribution of certain substances. Such substances include, in particular, biological populations. The first model of population growth, written in the form of a differential equation, was proposed by T. R. Malthus (Thomas Robert Malthus, 1766–1834) shortly after the discovery of differential and integral calculus (1798). This model considers a homogeneous population in conditions of unlimited food resources and habitat. At the same time, it is assumed that the growth rate of population is proportional to its size. The dynamics of such populations can be described by the ordinary differential equation (see, for example, [1–3]) \({du}/{dt}=Au,\) where \(A\) is the innate rate of natural population growth. The solution of this equation is the function
that is, over time, the population size grows indefinitely according to the exponential law. In accordance with this law, an isolated population would develop under conditions of unlimited resources. In nature, such conditions are practically not found. A few examples of breeding species brought to places, where there is a lot of food and there are no competing populations and predators, are known to everyone (rabbits in Australia). The Malthus equation accurately describes the dynamics of a population of protozoa artificially created and maintained in conditions of an excess of food and space, for example, penicillin fungi grown in a cultivator, until the culture medium is depleted.
Formula (1) adequately describes the process of population growth only for a limited period of time, since there comes a time when the growing population will exhaust the available resources. The population size may stabilize at some stable level, it may fluctuate regularly or irregularly, or it may contract. The behavior of a population whose size is stabilized at a certain equilibrium level is often described using the logistic equation proposed by P. F. Verhulst (Pierre François Verhulst, 1804–1849) in 1838:
The solution of this equation has the form
The direct study of this function shows that for small values of \(u\), the Verhulst equation can be replaced with sufficient accuracy by the Malthus equation, and the growth is explosive exponential, with an increase in the value of \(t\), the value of \(u(t)\) approaches a constant value of \(K\), called the capacity of the ecological niche of the population. Functions that satisfy such properties, differential equations that give such functions as solutions, as well as models that include such equations, are often called logistic.
It is well known that the partial stationary solution \(u(t)\equiv 0\) of the Verhulst equation is unstable. This is easily verified by using the first linear approximation. In the general case, for checking the stability of a stationary solution \(w\equiv{\textrm{const}}\) of equation \({du}/{dt}=f(u),\) that is, the solutions of equation \(f(w)=0,\) we have to check the sign of the derivative \(f^{\prime}(u)\) at the point \(u=w\). For the Verhulst equation, the function \(f(u)\) has the form
its derivative has the form
and at the point \(u=0\), it takes the value
Since the value of the derivative \(f^{\prime}(u)\) at the point \(u(t)\equiv 0\) is positive, the stationary solution of \(u(t)\equiv 0\) is unstable.
Systems of differential equations simulate the growth of phenomena of various types, and for all such systems, studies of the stability of stationary solutions play an important role. These studies have a long history. In many cases, such models are based on ordinary differential equations. Although the theory of systems of ordinary differential equations has long been classical, interest in it does not fade away. In the last few decades, this is also due to the fact that such systems have found applications in modelling biological and social systems. From relatively recent works on mathematical biology, it is possible to indicate in this regard [4–10]. In [11], a discrete version of the Ferhulst equation was used to study the spread of the COVID-19 coronavirus epidemic in Moscow. In the work [12], models of the origin and development of trends in painting are considered basing on the same principles as models of the growth of biological substances.
In 1921, H. Hotelling (Harold Hotelling, 1895–1973) proposed to describe animal and human populations, taking into account migration patterns in addition to the logistic law (see, for example, [13]). In order to do this, he proposed an equation of the form
where \(\Delta={\partial^{2}}/{\partial x^{2}}+{\partial^{2}}/{\partial y^{2}}\) is the Laplace operator, \(A\), \(B\), \(\xi\) are given positive constants. This equation describes the growth and spread of a population. In this case, the values included in the equation have the following meaning: \(A\) is a population growth rate, \(B\) is a distribution rate, \(\xi\) is a population saturation threshold (or saturated density coefficient), \(p\) is a size (density) of the population, \(t\) is a time, \(x,y\) are coordinates on the plane. The same equation is used to model the development of a malignant tumor [14]. The first term on the right side of the Hotelling equation is called a logistic term (growth component). The second term is usually called a diffusion term. It reflects the influence of migration (diffusion) processes on the change in population size. Equations and models reflecting changes in the size of biomass under the influence of logistic and diffusion components began to be called diffusion-logistic, and sometimes simply diffusion, implying, apparently, that the logistic component is present in the model by default. Such models can include not only one equation, but also systems of partial differential equations.
In this paper we consider a certain family of mathematical models with partial differential equations (models with distributed parameters), which are obtained from models with ordinary differential equations (models with concentrated parameters) by adding the so-called diffusion terms. The tendency of such sophistications of mathematical models can be traced in some works related to modelling the growth and distribution of populations, the growth and spread of infections, and the growth of tumors. In this regard, see first of all the monograph [2]. In the work [15], a diffusion model of a malignant tumor is presented. The mathematical model of glioma growth is based on the classical definition of cancer as uncontrolled proliferation of cells with the potential for invasion and metastasis, simplified for gliomas, which practically do not metastasize. This model is given in [14].
We are interested in the stability of stationary solutions of diffusion models. This issue is discussed in the book [2]. This book states that adding diffusion terms can change the stability of a stationary solution both for the worse and for the better. For models of a certain type, we try to concretize sufficient conditions for the stability of stationary solutions. Let’s first point to a simple example. In the monograph by T. Puu [13], using the Lyapunov function (Alexander Mikhailovich Lyapunov, 1857–1918) of a special kind, a sufficient condition for the stability of a regular stationary solution \(w\) of the initial boundary value problem with a boundary condition of the first, second or third kind for the Hotelling equation (2) in a bounded domain was found in the form \(w>{\xi}/{2}.\) Later this condition was improved (weakened), namely, it was shown that the condition \(w>{\xi}/{2}-{B}/{\left(2Ad^{2}\right)}\) is sufficient for the stability of a stationary solution \(w(x,y)\) of the initial boundary value problem with a boundary condition of condition of the first, second or third kind for the Hotelling equation (2) in a bounded domain with a diameter of \(d\) (see [16, 17]). This condition for \(B>0\) is satisfied for a small diameter of the domain \(\Omega\). It is necessary to pay attention to the following circumstance. The trivial solution is a stationary solution to the Hotelling equation both for \(B=0\) (in this case it coincides with the Verhulst equation) and for \(B>0\). However, in the case \(B=0\), as already noted, the trivial solution is unstable, and in the case \(B>0\) the trivial solution is stable. Below we extend the results of [16, 17] to one class of systems of partial differential equations.
2 INITIAL BOUNDARY VALUE PROBLEM UNDER STUDY
We consider the initial boundary value problem for a system of partial differential equations (see also [18, 19])
where \(\Omega\) is a bounded domain with a piecewise smooth boundary \(\partial\Omega\), \(\overrightarrow{\nu}\) \(=\nu\) is a unit external normal vector to the boundary \(\partial\Omega\) of the domain \(\Omega\), \(u=(u_{1}(x,t),\dots,u_{m}(x,t))\), \(\vartheta_{s}\geq 0\), \(u=(u_{1}(x,t),\dots,u_{m}(x,t))\), \(\vartheta_{s}\geq 0\), \(s=1,\dots,m,\) \(\Delta\) is the Laplace operator defined by the formula
Certainly, we must require the fulfillment of the conditions for matching the initial and boundary data. However, in the framework of this work, we are moving away from this issue. We assume that all conditions of existence of the classical (regular) solutions to the problem under consideration are satisfied, and in addition, all the original functions have the necessary properties allowing us to perform all the operations that we perform below. If
(in a model with concentrated parameters without diffusion terms), the variables \(x_{1},\dots,x_{n}\) are included in equations (3) as parameters whose derivatives are not contained in these equations. If \(\sum_{s=1}^{m}\vartheta_{s}^{2}>0,\) then we deal with a system with distributed parameters.
3 STATIONARY SOLUTION AND ITS STABILITY
Let \(w=w(x)=(w_{1}(x_{1},\dots,x_{n}),\dots,w_{m}(x_{1},\dots,x_{n}))\) be a stationary solution of the initial boundary value problem (3)–(5), that is, the solution of the boundary value problem
Suppose that the functions \(F_{s}(u)\), \(s=1,\dots,m,\) are differentiable at the point \(w\). Then for sufficiently small deviations \(z_{s}=z_{s}(x_{1},\dots,x_{n},t)=u_{s}-w_{s}\), \(s=1,\dots,m,\) we have
where
Substituting \(u_{s}=w_{s}+z_{s}\) into equation (3) and taking into account (7), we get
Considering that \(w\) is a stationary solution, we obtain from (8)
We multiply each \(s\)th equation of system (8) by \(z_{s}\) and integrate the obtained equality over the domain \(\Omega\). Taking into account (7), we obtain
The last term on the right side of equality (9) with small deviations of \(z\) does not affect the sign of the entire sum and can be discarded. We apply the Green formula (see [20]) to the first term on the right side of this equation. As a result, we get
where \(d\Gamma\) is an arc element of the boundary \(\partial\Omega\), i. e. the second term on the right side of equality (10) is a surface (for \(n\geq 3\)) or contour (for \(n=2\)) integral of the first kind over the boundary of the domain \(\Omega\), or the sum of values at the ends of the interval \(\Omega\) in the case of \(n=1\). In the integral over the boundary for \(\mu_{s}=0\) or for \(\eta_{s}=0\) the integrand is equal to zero due to the boundary condition (4). From the same boundary condition, when \(\mu_{s}\eta_{s}>0\), we get
Therefore, equality (10) can be rewritten as
where \(\sigma_{s}=\mu_{s}/\eta_{s}\) if \(\mu_{s}\eta_{s}>0\) or \(\sigma=0\) if \(\mu_{s}\eta_{s}=0\). Summing \(m\) equalities (11), we get
where \(\Theta_{sk}=(b_{sk}+b_{ks})/2.\) The sign of the left side of equality (12) is considered as an indicator of the stability of a trivial solution. Therefore, it is important to find the ratio of the terms in the right side, leading to the negativity of this expression. In parentheses on the right side, both the first term and the second term are not greater than zero. Next, we need to take into account the sign of the last term in the right part. Obviously, the negative definiteness of the quadratic form
will ensure the negativity of the left side of equality (12), and, therefore, the stability of the stationary solution. In the case of a model with concentrated parameters (a system of ordinary differential equations), that is, when conditions (6) are satisfied, negative definiteness of the quadratic form (13) is also a necessary condition for the stability of a trivial solution.
Let us consider the diffusion model with distributed parameters. In this case, it is possible to weaken the sufficient condition for the stability of a stationary solution. For this purpose, we use the Steklov–Poincare–Friedrichs inequality (see [21, p. 62; 22, p. 150; 23, 24])
where \(d={\textrm{diam}}\,\Omega\) is a diameter of the domain \(\Omega\). Hence
Now we can assert that a sufficient condition for the stability of a stationary solution is the negative definiteness of the quadratic form
where
4 EXAMPLES OF MATHEMATICAL MODELS IN BIOLOGY
4.1 The Lotka–Volterra Model
As an example we will consider the Lotka–Volterra system (Alfred James Lotka, 1880–1949; Vito Volterra, 1860–1940), which in a non-diffusion version has long been one of the main tools in mathematical ecology, genetics, and the mathematical theory of selection and evolution (see, for example, [1, 10]):
Coefficients (15) of the quadratic form (14) have the form
It is clear that due to the subtraction of positive terms \(\vartheta_{s}/d^{2}\) from diagonal elements of a matrix of quadratic form with coefficients (16), a sufficient condition for negative definiteness of a quadratic form in the diffusion model is less rigid than in the non-diffusion case. This can be demonstrated quite clearly by the example of a trivial solution. Condition \(\Phi_{s}<\vartheta_{s}/d^{2}\), \(s=1,\dots,m,\) is sufficient for the stability of a trivial solution of this system. For \(\vartheta_{s}>0\), \(s=1,\dots,m,\) that is, in the case of a diffusion model with distributed parameters, this condition is satisfied for domains with a small diameter. In the case of two equations, the model considered in this example turns into a predator-prey model. Without taking into account migrations (diffusion), the system of equations in the simplest version of this model has the following form (see, for example, [2])
The initial conditions are given in the form \(u_{s}(x,0)=u_{s}^{0},\ s=1,2.\) By adding the diffusion terms, we obtain the following system of partial differential equations
We consider the system of equations (17) in a bounded domain \(\Omega\) with a diameter \(d\), with a piecewise smooth boundary and we require the solution to fulfill the boundary conditions
and initial conditions
Let \(w=(w_{1},w_{2})\) be a stationary solution of the problem (17)–(19). Coefficients (15) of a quadratic form (14) for system (17) have the form
This quadratic form is negatively defined if and only if the following equalities are satisfied
Conditions (20), (21) are sufficient for the asymptotic stability of the stationary solution \(w\). Obviously, if the stationary solution is constant, these inequalities are certainly fulfilled in domains with small diameters. Therefore, stationary solutions of the diffusionless model \(w_{1}=w_{2}=0\) and \(w_{1}=m/(\kappa\beta)\), \(w_{2}=\alpha/\beta\), while remaining stationary solutions in the diffusion model in a domain with a small diameter (of course, with an appropriate set of initial and boundary conditions), change the nature of stability, namely, they become asymptotically stable. On the other hand, as shown in [2], a large value of a domain diameter can result in the so-called diffusion instability.
4.2 Diffusion Models of Oncological Processes
Let us consider the immune response model described in [15]. Let \(u_{1}\) be a linear density of dividing cells, \(q=q(x,t)\) be a linear density of lymphocytes. Then the mathematical model describing the interaction of dividing cells and lymphocytes, assuming the absence of their interaction with normal and dead cells, has the form
The model described in [15] is assumed to have the pointwise appearance of dividing cells. We consider a model with smooth distribution of dividing cells at the initial moment of time. Then we will have initial conditions of the form
When choosing boundary conditions, it is assumed that
A refined sufficient condition for the asymptotic stability of a stationary solution consists in the fulfillment of two inequalities [25]:
If we formally pass to a point model from model (22), discarding diffusion and convective terms with partial derivatives with respect to the spatial variable, we obtain the system of ordinary differential equations
It is obvious that a vector function with coordinates \(u_{1}=0,q=0\) is an unstable stationary solution of system (26). However, for system (22), the same vector function may also turn out to be a stable stationary solution if the following condition is satisfied:
Condition (25) for the zero solution turns out to be superfluous, since it becomes a consequence of condition (27).
In the work [25], in order to prove the sufficiency of conditions (24), (25), the authors had to use a weighted version of the Steklov–Poincare–Friedrichs inequality because of the convective term \(-v{\partial q}/{\partial x}\) in the second equation. Another weighted variant is used in the work [26], where it is shown that the condition
is sufficient for the asymptotic stability of the stationary solution \(p_{0}\) of the initial boundary value problem
Here \(B_{\gamma}\) is the Bessel operator defined by the formula
Very extensive information, including impressive literature reviews, about boundary value problems, functional spaces related to singular differential equations with the Bessel operator, see in [27–30].
4.3 Kermak–McKendrick Epidemic Model
As an example we consider the classical epidemic model of W. Kermak and A. McKendrick
where \(\beta\) and \(\gamma\) are positive constants. This model, proposed in 1927 (see [31]), characterizes the changes in the number of susceptible (S), infected (I), and recovered (R) individuals in the population in question. Subsequently, based on this model, an impressive number of models have been created, clarifying it and adapting to various situations. We change the model by adding a diffusion term to the right side of each equation, after that we obtain a system of partial differential equations
We consider system (28)–(30) in a domain \(\Omega\subset\mathbb{R}^{2}\) with a with a piecewise smooth boundary \(\Gamma=\partial\Omega\). We introduce uniform designations, which are consistent with the original model: \(u_{1}=u_{1}(x,t)=S\), \(u_{2}=u_{2}(x,t)=I\), \(u_{3}=u_{3}(x,t)=R\). Let us impose additional conditions on the solution \((u_{1},u_{2},u_{3})\)
–boundary:
–initial:
Here \(B_{j}(x)\in C(\partial\Omega)\), \(w_{j}(x)\in C^{2}(\Omega)\cap C(\overline{\Omega})\), \(j=1,2,3,\) \({\overline{\Omega}=\Omega\cup\partial\Omega}\,.\) Let the vector \(w=(w_{1}(x),w_{2}(x),w_{3}(x))\) be a stationary solution of system (28)–(30), that is, the solution of the system
satisfying the boundary conditions
This time, we obtain the inequality for the derivative of the Lyapunov function
where
Using the Sylvester criterion, we obtain the following sufficient conditions for negative definiteness of a quadratic form
These conditions are verifiable in practice, in computer simulations. Note that if we consider a trivial stationary solution \(w_{1}=w_{2}=w_{3}=0\) in the framework of this model, conditions (31)–(34) will take the form
In a model with concentrated parameters, that is, when \(\vartheta_{1}=\vartheta_{2}=\vartheta_{3}=0\), conditions (35)–(37) are not fulfilled, the trivial solution is unstable. In a model with distributed parameters, that is, when \(\vartheta_{1}\vartheta_{2}\vartheta_{3}>0\), conditions (35), (36) are fulfilled in any case, therefore, condition (37) becomes a substantial sufficient condition for the stability of a trivial solution. This condition, obviously, can be rewritten as
The fulfillment of this condition is possible for a domain with a small diameter. For domains with a large diameter, this condition is not satisfied.
5 MODELS IN HUMANITIES
5.1 The Hotelling Equation
We have already given one example above. The Verhulst model has an unstable trivial solution, which becomes stable if we add a diffusion term and proceed to the Hotelling model in a domain with a small diameter. Let’s note that the Hotelling equation describes the growth of a natural language vocabulary [32]).
5.2 On Modelling the Interaction of Language Groups
The model considered below in a non-diffusion form is borrowed from the work [12]. We supplement it to a diffusive form and give the quantities involved in it a different meaning. We still consider a new interpretation to be possible, basing on the already-mentioned principle of analogies in models constructing (see [33]). We realize that obtaining reliable data about the input values of the model, as well as about the desired values for its experimental verification, is a separate time-consuming task, which is not considered here.
Let \(u_{1}=u_{1}(x_{1},x_{2},t)\) and \(u_{2}=u_{2}(x_{1},x_{2},t)\) be the number (in arbitrary units) of groups of speakers of two languages (adverbs, dialects) living in the common territory. We will assume that the second group has ‘‘aggressiveness’’ in the following sense: due to the influence of the participants of the second group, a transition from the first group to the second group is possible. The system of ordinary differential equations, describing this process, has the form
where \({\alpha\in[0,1)}\), \(\mu\), \(\beta\), and \(b\) are some parameters. We add to the system (38)–(39) the initial conditions
In the diffusion version, the system takes the form
where \(\vartheta_{1}\geqslant 0\), \(\vartheta_{2}\geqslant 0\) (for \(\vartheta_{1}=0\), \(\vartheta_{2}=0\) we obtain the system (38)–(39) from [12]). We assume that the system is considered in a bounded domain \(\Omega\) with a piecewise smooth boundary \(\Gamma\). We add boundary conditions
where \(\nu\) is the unit vector of the external normal to the boundary \(\Gamma\), \(\eta_{s1}^{2}+\eta_{s2}^{2}>0\), \(\eta_{s1}\eta_{s2}>0\), \(s=1,2\). Everywhere further we will consider regular solutions with sufficient smoothness, what, in particular, entails the fulfillment of all the necessary conditions for matching the initial and boundary data.
Applying the above reasoning in this case, we get the inequality
where \(d\) is the diameter of the domain \(\Omega\),
A refined sufficient condition for the asymptotic stability of a stationary solution is the negative definiteness of the quadratic form
Certainly, checking this condition, although somewhat cumbersome, is still quite feasible, especially with the help of a computer.
It should be noted that taking into account diffusion phenomena can also introduce new knowledge about the object of research or about the model. Let’s turn to the primary source of the model under consideration. In the work [12] it is indicated that the system of ordinary differential equations (38)–(39) has four stationary points. Note that each of them is also a stationary solution of the system (40), (41) of partial differential equations with diffusion terms. In order to illustrate our thesis about new information about the object, we consider two of these stationary points.
1. \(v_{1}=\alpha,\ v_{2}=0.\)
At this stationary point, the eigenvalues of the matrix of the right side of the equations (38), (39) will have the form \(\lambda_{1}=\mu\alpha(1-\alpha)>0\), \(\lambda_{2}=-\beta(b-\alpha)\). Since one of the eigenvalues is positive, this stationary point will be unstable. We will study the influence of nonzero diffusion terms. It turns out that in this case the quadratic form (42) may be negatively defined if certain conditions are satisfied. In this case we have
According to the Sylvester criterion, for the negative definiteness of the form (42), it is necessary and sufficient to fulfill the conditions
It is quite obvious that each of these two conditions will be satisfied for sufficiently small \(d\).
2. \(v_{1}=1\), \(v_{2}=0.\)
At this point \(\lambda_{1}=-\mu(1-\alpha)<0\), \(\lambda_{2}=-\beta(b-1)\). The inequality \(b>1\) is a necessary and sufficient condition for the stability of the point \((1,0)\), considered as a stationary point of a system of ordinary differential equations (38), (39). Considering (40), (41), we have
Sylvester’s criterion for the negative definiteness of a quadratic form in this case will lead to the conditions
This time, the first condition is satisfied. The second condition can be satisfied for small values of \(d\), not only for \(b>1\), but also for \(b\leqslant 1\). Also worthy of note is the point \(v_{1}=0,\ v_{2}=0.\) At this stationary point, the eigenvalues of the matrix at the right side of equations (38)–(39) will be negative, and therefore this point will be stable. In this case, adding diffusion terms does not give anything new.
CONCLUSION
In this paper, we obtained a sufficient condition for the asymptotic stability of a stationary solution in a system of partial differential equations obtained from autonomous systems of ordinary differential equations by adding diffusion terms. It is noted that the nature of stability of constant stationary solutions changes when models with concentrated parameters are replaced by models with distributed parameters (in domains with small diameters for the better). It should be added that the obtained results also indicate the absence of the phenomenon known as Turing instability in many cases of domains with small diameters. In terms of population models, this fact means that migration processes contribute to the stability of stationary states in small domains.
REFERENCES
A. M. Nakhushev, Equations of Mathematical Biology (Vysshaya Shkola, Moscow, 1995) [in Russian].
Yu. M. Svirezhev and D. O. Logofet, Stability of Biological Communities (Nauka, Moscow, 1978) [in Russian].
F. Brauer and C. Castillo-Chavez, Mathematical Models in Population Biology and Epidemiology (Springer, Dordrecht, 2012).
V. Afraimovich, T. Young, M. K. Muezzinoglu, and M. I. Rabinovich, ‘‘Nonlinear dynamics of emotion-cognition interaction: When emotion does not destroy cognition?,’’ Bull. Math. Biol. 73, 266–284 (2011). https://doi.org/10.1007/s11538-010-9572-x
M. Anijil, N. Kavithal, and S. Balamuralitharan, ‘‘Approximate solutions for HBV infection with stability analysis using LHAM during antiviral therapy,’’ Boundary Value Probl. 2020, 80 (2020). https://doi.org/10.1186/s13661-020-01373-w
A. D’Onofrio and P. Manfredi, ‘‘The interplay between voluntary vaccination and reduction of risky behavior: A general behavior-implicit SIR model for vaccine preventable infections,’’ in Current Trends in Dynamical Systems in Biology and Natural Sciences, Vol. 21 of SEMA SIMAI Springer Series (Springer Nature, Switzerland AG, 2020), pp. 185–203.
H. Seno, ‘‘An SIS model for the epidemic dynamics with two phases of the human day-to-day activity,’’ J. Math. Biol. 80, 2109–2140 (2020). https://doi.org/10.1007/s00285-020-01491-0
S. I. Kabanikhina and O. I. Krivorotko, ‘‘Optimization methods for solving inverse immunology and epidemiology problems,’’ Comput. Math. Math. Phys. 60, 580–589 (2020).
O. F. Voropaeva and Ch. A. Tsgoev, ‘‘A numerical model of inammation dynamics in the core of myocardial infarction,’’ J. Appl. Ind. Math. 13, 372–383 (2019).
G. P. Karev, ‘‘Replicator equations and the principle of minimal production of information,’’ Bull. Math. Biol. 72, 1124–1142 (2010). https://doi.org/10.1134/S1990478919020182
E. M. Koltsova, E. S. Kurkina, and A. M. Vasetsky, ‘‘Mathematical modeling of the spread of COVID-19 in Moscow,’’ Komp’yut. Nanotekhnol. 7, 99–105 (2020). https://doi.org/10.33693/2313-223X-2020-7-1-99-105
E. P. Kolpak and A. V. Gavrilova, ‘‘Mathematical model of the emergence of cultural centers and trends in painting,’’ Young Scient. 22 (260), 1–17 (2019).
T. Puu, Nonlinear Economic Dynamics (Springer, Berlin, 1997). https://doi.org/10.1007/978-3-642-60775-2
K. R. Swanson, R. C. Rostomily, and E. C. Alvord, ‘‘A mathematical modelling tool for predicting survival of individual patients following resection of glioblastoma: A proof of principle,’’ Br. J. Cancer. 98, 113–119 (2008). https://doi.org/10.1038/sj.bjc.6604125
I. V. Zhukova and E. P. Kolpak, ‘‘Mathematical models of malignant tumour,’’ Vestn. SPb Univ., Ser. 10: Prikl. Mat. Inform. Protsessy Upravl. 3, 5–18 (2014).
V. Z. Meshkov, I. P. Polovinkin, and M. E. Semenov, ‘‘On the stability of a stationary solution of the Hotelling equation,’’ Appl. Ind. Math. Rev. 9, 226–227 (2002).
T. N. Gogoleva, I. N. Shchepina, M. V. Polovinkina, and S. A. Rabeeakh, ‘‘On stability of a stationary solution to the Hotelling migration equation,’’ J. Phys.: Conf. Ser. 1203, 012041-1–9 (2019).
M. V. Polovinkina and I. P. Polovinkin, ‘‘On the change in the nature of stability of a trivial solution in the transition from a model with lumped parameters to a model with distributed parameters,’’ Appl. Math. Phys. 52, 255–261 (2020). https://doi.org/10.18413/2687-0959-2020-52-4-255-261
M. V. Polovinkina ‘‘On the effect of transition from a model with concentrated parameters to a model with distributed parameters,’’ J. Phys.: Conf. Ser. 1902, 012041 (2021). https://doi.org/10.1088/1742-6596/1902/1/012041
D. Gilbarg and N. S. Trudinger, Elliptic Partial Differential Equations of Second Order (Springer, Berlin, 1983).
O. A. Ladyzhenskaya, Boundary Value Problems of Mathematical Physics (Springer, New York, 1985; Nauka, Moscow, 1973).
V. P. Mikhailov, Partial Differential Equations (Nauka, Moscow, 1976; Mir, Moscow, 1978).
K. O. Friedrichs, Spectral Theory of Operators in Hilbert Space (Springer, New York, 1973).
K. Rektorys, Variational Methods in Mathematics, Science and Engineering (Springer Science, New York, 2012).
A. Debbouche, M. V. Polovinkina, I. P. Polovinkin, C. A. Valentim, and S. A. David, ‘‘On the stability of stationary solutions in diffusion models of oncological processes,’’ Eur. Phys. J. Plus 136, 1–18 (2021). https://doi.org/10.1140/epjp/s13360-020-01070-8
M. V. Polovinkina, A. Debbouche, I. P. Polovinkin, and S. A. David, ‘‘Stability of stationary solutions for the glioma growth equations with radial or axial symmetries,’’ Math. Methods Appl. Sci. 44, 12021–12034 (2021). https://doi.org/10.1002/mma.7194
I. A. Kipriyanov, Singular Elliptic Boundary Value Problems (Nauka, Moscow, 1997) [in Russian].
V. V. Katrakhov and S. M. Sitnik, ‘‘The transmutation method and boundary-value problems for singular elliptic equations,’’ Soverm. Mat. Fundam. Napravl. 64, 211–426 (2018).
L. N. Lyahov, B-Hypersingular Integrals and their Applications to the Description of the Kupriyanov Functional Classes and to Integral Equations with B-Potential Nuclei (LSPU, Lipetsk, 2007) [in Russian].
S. M. Sitnik and E. L. Shishkina, Method of Transmutations for Differential Equations with Bessel Operators (Fizmatlit, Moscow, 2019) [in Russian].
W. O. Kermack and A. G. McKendrick, ‘‘A contribution to the mathematical theory of epidemics,’’ Proc. R. Soc. London, Ser. A 115, 700–721 (1927).
A. A. Kretov, M. V. Polovinkina, I. P. Polovinkin, and M. V. Lometc, ‘‘On some concepts of nonlinear dynamics suitable for use in linguistics,’’ J. Phys.: Conf. Ser. 1902, 012075 (2021). https://doi.org/10.1088/1742-6596/1902/1/012075
A. A. Samarskii and A. P. Mikhailov, Mathematical Modelling: Ideas. Methods. Examples (Fizmatlit, Moscow, 2002) [in Russian].
Author information
Authors and Affiliations
Corresponding authors
Additional information
(Submitted by A. B. Muravnik)
Rights and permissions
About this article
Cite this article
Polovinkina, M.V., Polovinkin, I.P. On the Stability of Stationary States in Diffusion Models in Biology and Humanities. Lobachevskii J Math 43, 1389–1400 (2022). https://doi.org/10.1134/S1995080222090220
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995080222090220