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Influence of Synthetic and Native Hydroxyapatite Nanoparticles on the Properties of Mesenchymal Stromal Cells of Bone Marrow

  • NANOBIOMEDICINE AND NANOPHARMACEUTICALS
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Abstract

The synthesis of new forms of hydroxyapatite (HA) and the study of their interaction with living cells are a promising area of modern nanotechnology in chemistry and cell biology. A comparative analysis of the interaction between HA nanoparticles of various origin with living cells is carried out. Scanning electron microscopy revealed that native HA (NHA) particles isolated from native bone tissue are several times larger than that of synthetic HA (SHA) synthesized by a sedimentation method. The pore size and specific surface area of SHA is more than three times larger than similar NHA parameters. The presence of SHA in the culture medium, together with mesenchymal stromal cells, reduces their adhesion, flattening, and proliferation, in contrast to the presence of NHA particles, which have virtually no negative effect on the growth and reproduction of living cells.

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Funding

The study was financed by the Russian Science Foundation (project no. 19-73-30003).

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Authors and Affiliations

  1. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

    Yu. A. Nashchekina

  2. Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia

    Yu. A. Nashchekina, I. P. Dobrovol’skaya, E. M. Ivan’kova & V. E. Yudin

  3. Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia

    I. P. Dobrovol’skaya, E. M. Ivan’kova & V. E. Yudin

Authors
  1. Yu. A. Nashchekina
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  2. I. P. Dobrovol’skaya
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  3. E. M. Ivan’kova
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  4. V. E. Yudin
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Correspondence to Yu. A. Nashchekina.

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Nashchekina, Y.A., Dobrovol’skaya, I.P., Ivan’kova, E.M. et al. Influence of Synthetic and Native Hydroxyapatite Nanoparticles on the Properties of Mesenchymal Stromal Cells of Bone Marrow. Nanotechnol Russia 15, 500–506 (2020). https://doi.org/10.1134/S1995078020040114

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  • DOI: https://doi.org/10.1134/S1995078020040114

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