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Acute inhalation toxicity of manganese oxide nanoparticles

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Abstract

Manganese oxides have been synthesized by the interaction of Mn2+ and Mn in the presence of nanoreactors: cetyltrimethylammonium bromide micelles that were not present in the final product composition. The synthesized substance is investigated using scanning electron microscopy, X-ray diffraction analysis, dynamic light scattering, the Brunauer-Emmett-Teller method, and the method of Barrett-Joyner-Halenda. It is determined that the substance under examination is a filamentous nanometer-scale material with a cross-section size up to 100 nm. The acute inhalation toxicity study is performed according to the interstate standard using the method of acute-toxicity class determination (ATC method) (OECD, Test no. 436:2008, IDT). The ATC method allows us to see that synthesized nanosized manganese oxide has an acute toxicity property when inhaled as an aerosol. Upon 4-h exposure to Wistar rats weighing 190 ± 10g, CL50 is 0.12 mg/L. The clinical picture of acute intoxication is characterized by irritation, neurotoxic effects, and respiratory depression. According to CL50 (>0.05–0.5), mg/L criterion, synthesized nanosized manganese oxide belongs to hazard class 2 in accordance with Globally Harmonized System of Classification and Labelling of Chemicals (GHS).

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Authors and Affiliations

  1. FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, ul. Monastyrskaya 82, Perm, 614045, Russia

    N. V. Zaitseva, M. A. Zemlyanova & V. N. Zvezdin

  2. Perm State University, ul. Bukireva 15, Perm, 614990, Russia

    T. I. Akafieva

  3. Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, ul. Akademika Koroleva 3, Perm, 614013, Russia

    E. V. Saenko

Authors
  1. N. V. Zaitseva
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  2. M. A. Zemlyanova
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  3. V. N. Zvezdin
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  4. T. I. Akafieva
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  5. E. V. Saenko
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Correspondence to N. V. Zaitseva.

Additional information

Original Russian Text © N.V. Zaitseva, M.A. Zemlyanova, V.N. Zvezdin, T.I. Akafieva, E.V. Saenko, 2015, published in Rossiiskie Nanotekhnologii, 2015, Vol. 10, Nos. 5–6.

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Zaitseva, N.V., Zemlyanova, M.A., Zvezdin, V.N. et al. Acute inhalation toxicity of manganese oxide nanoparticles. Nanotechnol Russia 10, 468–474 (2015). https://doi.org/10.1134/S1995078015030180

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  • DOI: https://doi.org/10.1134/S1995078015030180

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