Abstract
The conditions of succinylchitosan-based nanostructures with doxorubicin preparation were optimized. Nanoparticles were obtained using a precipitation conservation method for the first time, and the particles were further used to prepare noncovalent complexes with doxorubicin. The physicochemical and biological properties of the studied structures were investigated. It was shown that the average size of the obtained nanostructures is 200–250 nm and their ζ-potential was determined as negative (−20 to −25 mV). Nanoparticles loaded with doxorubicin were shown to demonstrate a positive cytotoxic effect in vitro. Doxorubicin sorbtion on nanoparticles resulted in no changes in the properties of the drug, which may make it possible to lower its toxicity in vivo.
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Original Russian Text © A.V. Il’ina, A.A. Zubareva, D.V. Kurek, A.N. Levov, V.P. Varlamov, 2012, published in Rossiiskie Nanotekhnologii, 2012, Vol. 7, Nos. 1–2.
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Il’ina, A.V., Zubareva, A.A., Kurek, D.V. et al. Nanoparticles based on succinylchitosan with doxorubicin: Preparation and properties. Nanotechnol Russia 7, 85–92 (2012). https://doi.org/10.1134/S1995078012010107
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DOI: https://doi.org/10.1134/S1995078012010107