Abstract
Novel biocompatible protein-oleic acid conjugate was prepared to form self-assembled nanoparticles (NP) when exposed to an aqueous medium. The conjugation of protein-fatty acid was confirmed using FTIR and NMR. The physicochemical properties of NP were characterized by the experimental conditions such as pH, temperature and the amount of protein/fatty acid. The self-assembled NP had a uniformly spherical shape with particle size (150-200 nm) and showed good physical stability. This NP had no any potential cellular toxicity. Paclitaxel was chosen as model drug for anti-cancer effect using self-assembled NP. Drug release was controlled over an extended period of time. Furthermore, surface-modified NP using folic acid showed a higher cancer-cell killing effect as compared with Taxol®. The in vivo pharmacokinetic parameters and biodistribution of the NP containing paclitaxel also indicated longer blood circulation.
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© 2013 IFMBE
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Lee, BJ., Tran, P.HL. (2013). Protein-Fatty Acid Conjugate for Self-assembled Nanoparticles in Drug Delivery. In: Toi, V., Toan, N., Dang Khoa, T., Lien Phuong, T. (eds) 4th International Conference on Biomedical Engineering in Vietnam. IFMBE Proceedings, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32183-2_75
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DOI: https://doi.org/10.1007/978-3-642-32183-2_75
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-32182-5
Online ISBN: 978-3-642-32183-2
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