Abstract
Rats with experimental parkinsonism induced by intraperitoneal daily administration of rotenone (2.75 mg/kg) during seven days are characterized by an increased activity of prolyl endopeptidase (PEP; ЕС 3.4.21.26) in serum and a decreased activity of adenosine deaminase (ADA; EC 3.5.4.4) in serum and in the prefrontal cortex. PEP and ADA activities in other brain structures (in the striatum, hypothalamus, and hippocampus) as well as activity of dipeptidyl peptidase IV (DPP-4, CD26; ЕС 3.4.14.5) in serum and in all the brain structures investigated remained unchanged. Afobazole and levodopa, which exhibit antiparkinsonian activity in this model of parkinsonism, decreased the elevated PEP activity in serum and increased ADA activity reduced in the prefrontal cortex of rats with the experimental pathology. At the same time, treatment with these drugs resulted in a decrease of ADA activity in the other brain structures.
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Duty, S. and Jenner, P., Br. J. Pharmacol., 2011, vol. 164, pp. 1357–1391. doi 10.1111/j.1476-5381. 2011.01426.x
Brandt, I., Gerard, M., Sergeant, K., Devreese, B., Baekelandt, V., Augustyns, K., Scharpe, S., Engelborghs, Y., and Lambeir, A.M., Peptides, 2008, vol. 29, pp. 1472–1478. doi 10.1016/j.peptides.2008.05.005
Myöhänen, T.T., Hannula, M.J., Van Elzen, R., Gerard, M., Van Der Veken, P., García-Horsman, J.A., Baekelandt, V., Männistö, P.T., and Lambeir, A.M., Br. J. Pharmacol., 2012, vol. 166, no. 3, pp. 1097–1113. doi 10.1111/j.1476-5381.2012.01846.x
Sedo, A., Duke-Cohan, J.S., Balaziova, E., and Sedova, L.R., Arthritis. Res. Ther., 2005, vol. 7, no. 6, pp. 253–269. doi 10.1186/ar1852
Ferre, S., Herrera-Marschitz, M., Grabowska-Anden, M., Ungerstedt, U., Casas, M., and Anden, N.E., Eur. J. Pharmacol., 1991, vol. 192, no. 1, pp. 25–30.
Richardson, P.J., Gubitz, A.K., Freeman, T.C., and Dixon, A.K., Adv. Neurol., 1999, vol. 80, pp. 111–119.
Schwarzschild, M.A., Agnati, L., Fuxe, K., Chen, J.F., and Morelli, M., Trends Neurosci., 2006, vol. 29, no. 11, pp. 647–654. doi 10.1016/j.tins.2006.09.004
Boison, D., Curr. Top. Med. Chem., 2011, vol. 11, no. 8, pp. 1068–1086.
Tarasova, E.O., Gaidukov, A.E., and Balesina, O.P., Sovr. Probl. Nauki i Obrazovaniya, 2014, no. 3, p. 623.
Sperlágh, B. and Vizi, E.S., Curr. Top. Med. Chem., 2011, vol. 11, no. 8, pp. 1034–1046.
Shiozaki, S., Ichikawa, S., Nakamura, J., Kitamura, S., Yamada, K., and Kuwana, Y., Psychopharmacology (Berl.), 1999, vol. 147, pp. 90–95.
Correa, M., Wisniecki, A., Betz, A., Dobson, D.R., O’Neill, M.F., O’Neill, M.J., and Salamone, J.D., Behav. Brain Res., 2004, vol. 148, pp. 47–54.
Ivanova, E.A., Zolotov, N.N., Kapitsa, I.G., Pozdnev, V.F., Valdman, E.A., and Voronina, T.A., Immunologiya, 2017, vol. 38, no. 4, pp. 213–218.
Kapitsa, I.G., Ivanova, E.A., Valdman, E.A., and Voronina, T.A., Eksper. Klin. Farmakol., 2017, vol. 80, no. 6, pp. 3–7.
Cannon, J.R., Tapias, V., Na, H.M., Honick, A.S., Drolet, R.E., and Greenamyre, J.T., Neurobiol. Dis., 2009, vol. 34, no. 2, pp. 279–290. doi 10.1016/j.nbd.2009.01.016
Zolotov, N.N., Kutepova, O.A., Voronina, T.A., Pozdnev, V.F., Smirnov, L.D., and Dyumaev, K.M., Dokl. Akad. Nauk SSSR, 1991, vol. 317, no. 1, pp. 234–237.
Kaplan, N.O., Colowick, S.P., and Ciotti, M.M., J. Biol. Chem., 1952, vol. 194, pp. 579–591.
Seredenin, S.B., Ostrovskaya, R.U., Voronina, T.A., Zolotov, N.N., Yarkova, M.A., and Durnev, A.D., Rus. Patent 2597848, 12.03.2013.
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Original Russian Text © E.A. Ivanova, N.N. Zolotov, I.G. Kapitsa, V.F. Pozdnev, E.A. Valdman, T.A. Voronina, 2018, published in Biomeditsinskaya Khimiya.
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Ivanova, E.A., Zolotov, N.N., Kapitsa, I.G. et al. The Effect of Afobazole and Levodopa on Activity of Proline-Specific Proteinases and Adenosine Deaminase in Serum and Brain Structures of Rats with Experimental Parkinsonism Induced by Systemic Administration of Rotenone. Biochem. Moscow Suppl. Ser. B 12, 186–190 (2018). https://doi.org/10.1134/S1990750818020063
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DOI: https://doi.org/10.1134/S1990750818020063