Abstract
Furin belongs to intracellular serine Ca2+-dependent endopeptidases of the subtilisin family, also known as proprotein convertases (PC). Human furin is synthesized as a zymogen with a molecular weight of 104 kDа, which is then autocatalytically activated in two stages. This process occurs during zymogen migration from the endoplasmic reticulum to the Golgi apparatus, where a large part of furin is accumulated. The molecular weight of the active furin is 98 kDа. Furin is the enzyme with narrow substrate specificity: it hydrolyzes peptide bonds at the site of paired basic amino acids and is active in a wide range of pH (5.0–8.0). The main biological function of furin as PC consists in activation of functionally important protein precursors. This is accompanied by initiation of cascades of reactions, which lead to appearance of biologically active molecules involved in realization of specific biological functions both in normal and in some pathological processes. The list of furin substrates includes biologically important proteins such as enzymes, hormones, growth/differentiation, receptors, adhesion proteins, plasma proteins. Furin plays an important role in the development of such processes as proliferation, invasion, cell migration, survival, maintenance of homeostasis, embryogenesis, as well as the development of a number of pathologies, including cardiovascular, cancer, and neurodegenerative diseases. Furin and furin-like proprotein convertases are key factors in the realization of the regulatory functions of proteolytic enzymes; the latter is currently considered as the most important function (compared with well recognized protease function in degradation of proteins).
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Thomas, G., Nat. Rev. Mol. Cell. Biol., 2002, vol. 3, pp. 753–766. doi 10.1038/nrm934
Artenstein, A. and Opal, S., N. Engl. J. Med., 2011, vol. 365, pp. 2507–2518. doi 10.1056/NEJMra1106700
Henrich, S., Lindberg, I., Bode, W., and Than, M., J. Mol. Biol., 2005, vol. 345, pp. 211–227. doi 10.1016/j.jmb.2004.10.050
Seidah, N.G. and Prat, A., Nat. Rev. Drug Discov., 2012, vol. 11, pp. 367–383.
Henrich, S., Cameron, A., Bourenkov, G., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., and Than, M.E., Nat. Struct. Biol., 2003, vol. 10, pp. 520–526. doi 10.1038/nsb941
Anderson, E., VanSlyke, J., Thulin, C.D., Jean, F., and Thomas, G., EMBO J., 1997, vol. 16, pp. 108–118. doi 10.1093/emboj/16.7.1508
Molloy, S.S., Thomas, L., Van Slyke, J.K., Stenberg, P.E., and Thomas. G., EMBO J., 1994, vol. 13, pp. 18–33.
Paleyanda, R.K., Drews, R., Lee, T.K., and Luboń, H., J. Biol. Chem., 1997, vol. 272, pp. 15270–15274.
Dahms, S.O., Hardes, K., Becker, G.L., Steinmetzer, T., Brandstetter, H., and Than, M.E., ACS Chem. Biol., 2014, vol. 9, pp. 1113–1118. doi 10.1021/cb500087x
Nakayama, K., Biochem. J., 1997, vol. 327, pp. 625–635.
Molloy, S.S., Bresnahan, P.A., Leppla, S.H., Klimpel, K.R., and Thomas, G., J. Biol. Chem., 1992, vol. 267, pp. 16396–16402.
Stieneke-Gröber, A., Vey, M., Angliker, H., Shaw, E., Thomas, G., Roberts, C., Klenk, H.D., and Garten, W., EMBO J., 1992, vol. 11, pp. 2407–2414.
Schechter, I. and Berger, A., Biochem. Biophys. Res. Commun., 2012, vol. 425, pp. 497–502. doi 10.1016/j.bbrc.2012.08.015
Rockwell, N.C. and Fuller, R.S., J. Biol. Chem., 2002, vol. 277, pp. 1731–1737. doi 10.1074/jbc.M111909200
Couture, F., D’Anjou, F., and Day, R., Biomol. Concepts, 2011, vol. 2, pp. 421–438.
Kibirev, V.K. and Osadchuk, T.V., Ukr. Biokhim. Zh., 2012, vol. 84, pp. 5–29.
Couture, F., Kwiatkowska, A., Dory, Y.L., and Day, R., Expert Opin. Ther. Pat., 2015, vol. 25, pp. 379–396. doi 10.1517/13543776.2014.1000303
Fugére, M. and Day, R., Trends Pharm. Sci., 2005, vol. 26, pp. 294–301. doi 10.1016/j.tips.2005.04.006
Basak, A., J. Mol. Med., 2005, vol. 83, pp. 844–855. doi 10.1007/s00109-005-0710-0
Zhong, M., Munzer, J. S., Basak, A., Benjannet, S., Mowla, S.J., Decroly, E., Chrétien, M., and Seidah, N.G., J. Biol. Chem., 1999, vol. 274, pp. 33913–33920.
Anderson, E.D., Thomas, L., Hayflick, J.S., and Thomas, G., J. Biol. Chem., 1993, vol. 268, pp. 24887–24891.
Hardes, K., Becker, G.L., Lu, Y., Dahms, S.O., Köhler, S., Beyer, W., Sandvig, K., Yamamoto, H., Lindberg, I., Walz, L., von Messling, V., Than, M.E., Garten, W., and Steinmetzer, T., Chem. Med. Chem., 2015, vol. 10, pp. 1218–1231. doi 10.1002/cmdc.201500103
Harris, N.C. and Achen, M.G., Curr. Med. Chem., 2014, vol. 21, pp. 1821–1842.
Hallenberger, S., Bosch, V., Angliker, H., Shaw, E., Klenk, H.D., and Garten, W., Nature, 1992, vol. 360, pp. 358–361. doi 10.1038/360358a0
Bassi, D.E., Fu, J., Lopez de Cicco, R., and Klein-Szanto, A.J., Mol. Carcinog., 2005, vol. 44, pp. 151–161. doi 10.1002/mc.20134
Craik, D.J., Fairlie, D.P., Liras, S., and Price, D., Chem. Biol. Drug Des., 2013, vol. 81, pp. 136–147. doi 10.1111/cbdd.12055
Stawowy, P., and Fleck, E., J. Mol. Med., 2005, vol. 83, pp. 865–875. doi 10.1007/s00109-005-0723-8
de Cicco, R.L., Bassi, D.E., Benavides, F., Conti, C.J., and Klein-Szanto, A.J., Mol. Carcinog., 2007, vol. 46, pp. 654–659. doi 10.1002/mc.20331
Coppola, J.M., Bhojani, M.S., Ross, B.D., and Rehemtulla, A.A., Neoplasia, 2008, vol. 10, pp. 363–370.
Siegfried, G., Basak, A., Cromlish, J.A., Benjannet, S., Marcinkiewicz, J., Chrétien, M., Seidah, N.G., and Khatib, A.M., J. Clin. Invest., 2003, vol. 111, pp. 1723–1732. doi 10.1172/JCI17220
Dragulescu-Andrasi, A.I., Liang, G., and Rao, J., Bioconjug. Chem., 2009, vol. 20, pp. 1660–1666. doi 10.1021/bc9002508
Longuespée, R., Couture, F., Levesque, C., Kwiatkowska, A., Desjardins, R., Gagnon, S., Vergara, D., Maffia, M., Fournier, I., Salzet, M., and Day, R., Transl Oncol., 2014, vol. 7, pp. 410–419. doi 10.1016/j.tranon.2014.04.008
Bassi, D.E., Lopez De Cicco, R., Mahloogi, H., Zucker, S., Thomas, G., and Klein-Szanto, A.J., Proc. Natl. Acad. Sci., 2008, vol. 98, pp. 10326–10331. doi 10.1073/pnas.191199198
Hellawell, G.O. and Brewster, S.F., BJU Int., 2002, vol. 89, pp. 230–240.
Zhavrid, E.A., Antonenkova, N.N., Prokhorova, V.I., and Lappo, S.V., Meditsinskie Novosti, 2010, vol. 5, pp. 12–17.
Bochkareva, N.V., Kondakova, I.V., Kolomiets, L.A., and Muntyan, A.B., Sibirskyi Onkologicheskyi Zhurnal, 2011, vol. 45, pp. 74–81.
Itoh, Y., Matrix Biol., 2015, vols. 44−46, pp. 207–223. doi 10.1016/j.matbio.2015.03.004
Sato, H., Kinoshita, T., Takino, T., Nakayama, K., and Seiki, M., FEBS Lett., 1996, vol. 393, pp. 101–104.
Remacle, A.G., Rozanov, D.V., Fugere, M., Day, R., and Strongin, A.Y., Oncogene, 2006, vol. 25, pp. 5648–5655. doi 10.1038/sj.onc.1209572
Ala-Aho, R. and Kahari, V.M., Biochemie, 2005, vol. 87, pp. 273–286. doi 10.1016/j.biochi. 2004.12.009
Pitliak, M., Vargova, V., and Mechirova, V., Oncologie, 2012, vol. 35, pp. 49–53. doi 10.1159/000336304
Libra, M., Scalisi, A., Vella, N., Clement, S., and Sorio, R., Int. J. Oncol., 2009, vol. 34, pp. 897–903. doi 10.3892/ijo_000002
Hadler-Olsen, E., Fadnes, B., Sylte, I., Uhlin-Hansen, L., and Winberg, J.O., FEBS J., 2011, vol. 278, pp. 28–45. doi 10.1111/j.1742-4658.2010.07920.x
Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M., Nature, 1994, vol. 370, pp. 61–65.
Holmbeck, K., Bianco, P., Yamada, S., and Birkedal-Hansen, H., J. Cell. Physiol., 2004, vol. 200, pp. 11–19. doi 10.1002/jcp.20065
Bauvois, B., Biochim. Biophys. Acta, 2012, vol. 1825, pp. 29–36. doi 10.1016/j.bbcan.2011.10.001
Knäuper, V., Will, H., López-Otin, C., Smith, B., Atkinson, S.J., Stanton, H., Hembry, R.M., and Murphy, G., J. Biol. Chem., 1996, vol. 271, pp. 17124–17131.
Morrison, C.J. and Overall, C.M., J. Biol. Chem., 2006, vol. 281, pp. 26528–26539. doi 10.1074/jbc.M603331200
Kadono, Y., Shibahara, K., Namiki, M., Watanabe, Y., Seiki, M., and Sato, H., Biochem. Biophys. Res. Commun., 1998, vol. 251, pp. 681–687. doi 10.1006/bbrc.1998.9531
Hiraoka, N., Allen, E., Apel, I.J., Gyetko, M.R., and Weiss, S.J., Cell, 1998, vol. 95, pp. 365–377. doi 10.1016/S0092-8674(00)81768-7
Sakamoto, T. and Seiki, M., Genes Cells, 2009, vol. 14, pp. 617–626. doi 10.1111/j.1365-2443.2009.01293.x
Belien, A.T., Paganetti, P.A., and Schwab, M.E., J. Cell Biol., 1999, vol. 144, pp. 373–384. doi 10.1083/jcb.144.2.373
Poincloux, R., Lizárraga, F., and Chavrier, P., J. Cell. Sci., 2009, vol. 122, pp. 3015–3024. doi 10.1242/jcs.034561
Deryugina, E.I., Soroceanu, L., and Strongin, A.Y., Cancer Res., 2002, vol. 62, pp. 580–588.
Sodek, K.L., Ringuette, M.J., and Brown, T.J., Br. J. Cancer., 2007, vol. 97, pp. 358–367. doi 10.1038/sj.bjc.6603863
Vos, M.C., van der Wurff, A.A., Bulten, J., Kruitwagen, R., Feijen, H., van Kuppevelt, T.H., Hendriks, T., and Massuger, L.F., Diagn. Pathol., 2016, vol. 11, p. 34. doi 10.1186/s13000-016-0485-3
Linder, S., J. Cell. Biol., 2015, vol. 211, pp. 215–217. doi 10.1083/jcb.201510009
Solovyeva, N.I., Timoshenko, O.S., Gureeva, T.A., and Kugaevskaya, E.V., Biomed. Khim., 2015, vol. 61, pp. 694–704. doi 10.18097/PBMC20156106694
Timoshenko, O.S., Gureeva, T.A., Kugaevskaya, E.V., and Solovyeva, N.I., Biomed. Khim., 2014, vol. 60, pp. 683–688. doi 10.18097/PBMC20146006683
Ryzhakova, O.S., Gureeva, T.A., Zhurbitskaya, V.A., and Solovyeva, N.I., Biomed. Khim., 2007, vol. 53, pp. 322–331.
Cao, J., Chiarelli, C., Kozarekar, P., and Adler, H.L., Thromb. Haemost., 2005, vol. 93, pp. 770–778. doi 10.1160/TH04-08-0555
Wang, J., Voellger, B., Benzel, J., Schlomann, U., Nimsky, C., Bartsch, J.W., and Carl, B., Int. J. Cancer, 2016, vol. 139, pp. 1327–1339. doi 10.1002/ijc.30173
Zhao, J., Kong, Z., Xu, F., and Shen, W., Tumour Biol., 2015, vol. 36, pp. 8609–8615. doi 10.1007/s13277-015-3558-0
Shuldiner, A.R., Barbetti, F., Raben, N., Scavo, L., and Serrano, J., in Insulin-Like Growth Factors: Molecular and Cellular Aspects, LeRoith, D., Ed., Boca Raton, Florida: CRC Press, 1998, pp. 181–219.
Duguay, S.J., Lai-Zhang, J., and Steiner, D.F., J. Biol. Chem., 1995, vol. 270, pp. 17566–17574. doi 10.1074/jbc.270.29.17566
Khatib, A.M., Siegfried, G., Prat, A., Luis, J., Chrétien, M., Metrakos, P., and Seidah, N.G., J. Biol. Chem., 2001, vol. 276, pp. 30686–30693. doi 10.1074/jbc.M101725200
Ullrich, A., Gray, A., Tam, A.W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kathuria, S., Chen, E., Jacobs, S., Francke, U., Ramachandran, J., and Fujita-Yamaguchi, Y., EMBO J., 1986, vol. 5, pp. 2503–2512.
Zhang, D., Bar-Eli, M., Meloche, S., and Brodt, P., J. Biol. Chem., 2004, vol. 279, pp. 19683–19690. doi 10.1074/jbc.M313145200
Bruchim, I., Attias, Z., and Werner, H., Exper. Opin. Ther. Targets, 2009, vol. 13, pp. 1179–1192. doi 10.1517/14728220903201702
Arnaldez, F.I. and Helman, L.J., Hematol. Oncol. Clin. North Am., 2012, vol. 26, pp. 527–542. doi 10.1016/j.hoc.2012.01.004
Adams, T.E., Epa, V.C., Garrett, T.P., and Ward, C.W., Cell Mol. Life Sci., 2000, vol. 57, pp. 1050–1093. doi 10.1007/PL00000744
Sehat, B., Andersson, S., Vasilcanu, R., Girnita, L., and Larsson, O., PLoS One, 2007, vol. 2, p. 340. doi 10.1371/journal.pone.0000340
Singh, P., Alex, J.M., and Bast, F., Med. Oncol., 2014, vol. 31, p. 805. doi 10.1007/s12032-013-0805-3
Abdel-Wahab, R., Shehata, S., Hassan, M.M., Habra, M.A., Eskandari, G., Tinkey, P.T., Mitchell, J., Lee, J.S., Amin, H.M., and Kaseb, A.O., Hepatocell. Carcinoma, 2015, vol. 2, pp. 131–142. doi 10.2147/JHC
Potente, M., Gerhardt, H., and Carmeliet, P., Cell, 2011, vol. 146, pp. 873–887. doi 10.1016/j.cell.2011.08.039
Basak, A., Khatib, A.M., Mohottalage, D., Basak, S., Kolajova, M., Bag, S.S., and Basak, A., PLoS One, 2009, vol. 4, e7700. doi 10.1371/journal.pone.0007700
Shibuya, M. and Claesson-Welsh, L., Exper. Cell Res., 2006, vol. 312, pp. 549–560. doi 10.1016/j.yexcr.2005.11.012
Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson-Welsh, L., Cao, Y., Saksela, O., Kalkkinen, N., and Alitalo, K., EMBO J., 1997, vol. 16, pp. 3898–3911. doi 10.1093/emboj/16.13.3898
Karamysheva, A.F., Biochemistry (Moscow), 2008, vol. 73, pp. 751–762.
Holmes, K., Roberts, O.L., Thomas, A.M., and Cross, M.J., Cell Signal., 2007, vol. 19, pp. 2003–2012. doi 10.1016/j.cellsig.2007.05.013
Johnsson, A., Heldin, C.H., Westermark, B., and Wasteson, A., Biochem. Biophys. Res. Commun., 1982, vol. 104, pp. 66–74.
Heldin, C.H., Ostman, A., and Rönnstrand, L., Biochim. Biophys. Acta, 1998, vol. 1378, pp. 79–113.
Ostman, A. and Heldin, C.H., Adv. Cancer Res., 2007, vol. 97, pp. 247–274. doi 10.1016/S0065-230X(06)97011-0
Siegfried, G., Khatib, A.M., Benjannet, S., Chre, M., and Seidah, N.G., Cancer Res., 2003, vol. 63, pp. 1458–1463.
George, D., Semin. Oncol., 2001, vol. 28, pp. 27–33. doi 10.3171/jns.1995.82.5.0864
Abe, H., Hino, R., and Fukayama, M., Virchows Arch., 2013, vol. 462, pp. 523–531. doi 10.1007/s00428-013-1403-7
Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Bäckström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C.H., Alitalo, K., Ostman, A., and Eriksson, U., Nat. Cell Biol., 2000, vol. 2, pp. 302–309. doi 10.1038/35010579
Zhang, J.B., Sun, H.C., and Jia, W.D., BMC Cancer, 2012, vol. 12, p. 439. doi 10.1186/1471-2407-12-439
Fredriksson, L., Li, H., and Eriksson, U., Cytokine Growth Factor Rev., 2004, vol. 15, pp. 197–204. doi 10.1016/j.cytogfr.2004.03.007
Piccaluga, P.P., Rossi, M., and Agostinelli, C., Leukemia, 2014, vol. 28, pp. 1687–1697. doi 10.1038/leu.2014.50
Jain, R.K., Lahdenranta, J., Fukumura, D., PLoS Med., 2008, vol. 5, no. 1, e24. doi 10.1371/journal. pmed.0050024
Massague, J., Ann. Rev. Cell. Biol., 1990, vol. 6, pp. 597–641. doi 10.1146/annurev.cb. 06.110190.003121
Padua, D. and Massagué, J., Cell Res., 2009, vol. 19, pp. 89–102. doi 10.1038/cr.2008.316
Massagué, J., J. Cell, 2008, vol. 134, pp. 215–230. doi 10.1016/j.cell.2008.07.001
Lebrun, J.J., ISRN Mol. Biol., 2012, vol. 2012, pp. 381–428. doi 10.5402/2012/381428
Caja, F. and Vannucci, L., J. Immunotoxicol., 2015, vol. 12, pp. 300–307. doi 10.3109/1547691X.2014.945667
Tian, F., DaCosta, B.S., Parks, W.T., Yoo, S., Felici, A., Tang, B., Piek, E., Wakefield, L.M., and Roberts, A.B., Cancer Res., 2003, vol. 63, pp. 8284–8292.
Weeks, B.H., He, W., Olson, K.L., and Wang, X.J., Cancer Res., 2001, vol. 61, pp. 7435–7443.
Muraoka-Cook, R.S., Dumont, N., and Arteaga, C.L., Clin. Cancer Res., 2005, vol. 11, pp. 937–943.
Kawata, M., Koinuma, D., Ogami, T., Umezawa, K., Iwata, C., Watabe, T., and Miyazono, K., J. Biochem., 2012, vol. 151, pp. 205–216. doi 10.1093/jb/mvr136
Katsuno, Y., Lamouille, S., and Derynck, R., Curr. Opin. Oncol., 2013, vol. 25, pp. 76–84. doi 10.1097/CCO.0b013e32835b6371
Dobolyi, A., Vineze, C., Pal, G., and Lovas, G., Int. Mol. Sci., 2012, vol. 13, pp. 8219–8258. doi 10.3390/ijms13078219
Henry, J.P., Gauer, O.H., and Reeves, J.L., Circulat. Res., 1956, vol. 4, pp. 85–90.
Maack, T., Arq. Bras. Endocrinol. Metab., 2006, vol. 50, pp. 198–207. doi S0004-27302006000200006
Kozlov, I.A., Tyurin, I.N., Avdeikin, S.N., Ufimtseva, I.Yu., Salikov, A.V., and Karpun, N.A., Obshchaya Reanimatologiya, 2016, vol. 12, pp. 24–33. http://dx.doi.org/doi 10.15360/1813-9779-2016-3-24-33
Ogawa, Y., Itoh, H., and Nakao, K., Clin. Exp. Pharmacol. Physiol., 1995, vol. 22, pp. 49–53.
Potter, L.R., FEBS J., 2011, vol. 278, pp. 1808–1817. doi 10.1111/j.1742-4658.2011.08082.x
Potter, L.R., Yoder, A.R., Flora, D.R., Antos, L.K., and Dickey, D.M., Handb. Exp. Pharmacol., 2009, vol. 191, pp. 341–366. doi 10.1007/978-3-540-68964-5_15
Medvedev, A.E., Biomed. Khim., 2007, vol. 53, pp. 471–487.
Nishikimi, T., Kuwahara, K., and Nakao, K., J. Cardiol., 2011, vol. 57, pp. 131–140. doi 10.1016/j.jjcc.2011.01.002
Sellitti, D.F., Koles, N., and Mendonça, M.C., Peptides, 2011, vol. 32, pp. 1964–1971. doi 10.1016/j.peptides. 2011.07.013
Yandle, T.G., J. Intern. Med., 1994, vol. 235, pp. 561–576.
Medvedev, A., Igosheva, N., Crumeyrolle-Arias, M., and Glover, V., Stress, 2005, vol. 8, pp. 175–183. doi 10.1080/10253890500342321
Silberbach, M. and Roberts, C.T., Jr., Cell Signal., 2001, vol. 13, pp. 221–231.
Semenov, A.G. and Seferian, K.R., Clin. Chim. Acta, 2011, vol. 412, pp. 850–860. doi 10.1016/j.cca.2011.03.006
Potter, L.R., Yoder, A.R., Flora, D.R., Antos, L.K., and Dickey, D.M., Exp. Pharmacol., 2009, vol. 191, pp. 341–366. doi 10.1007/978-3-540-68964-5_15
Thibault, G., Murthy, K.K., Gutkowska, J., Seidah, N.G., Lazure, C., Chrétien, M., and Cantin, M., Peptides, 1998, vol. 9, pp. 47–53.
McDowell, G., Patterson, C., Maguire, S., Shaw, C., Nicholls, D.P., and Hall, C., Eur. J. Clin. Invest., 2002, vol. 32, pp. 545–548.
Vesely, D.L., J. Investig. Med., 2005, vol. 53, pp. 360–365. doi 10.2310/6650.2005.53708
Vesely, D.L., Vesely, B.A., Eichelbaum, E.J., Sun, Y., Alli, A.A., and Gower, W.R., In Vivo, 2007, vol. 21, pp. 973–978.
Saba, S.R. and Vesely, D.L., Histol. Histopathol., 2006, vol. 21, pp. 775–783.
Pemberton, C.J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S.C., Yandle, T.G., and Richards, A.M., Clin. Chem., 2012, vol. 58, pp. 757–767. doi 10.1373/clinchem.2011.176990
Jessup, M., Abraham, W.T., Casey, D.E., Feldman, A.M., Francis, G.S., Ganiats, T.G., Konstam, M.A., Mancini, D.M., Rahko, P.S., Silver, M.A., Stevenson, L.W., and Yancy, C.W., Circulation, 2009, vol. 119, pp. 1977–2016. doi 10.1161/CIRCULATIONAHA.109.192064
Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J.J., Ponikowski, P., Poole-Wilson, P.A., Strömberg, A., van Veldhuisen, D.J., Atar, D., Hoes, A.W., et al., Eur. Heart. J., 2008, vol. 19, pp. 2388–2442. doi 10.1093/eurheartj/ehn309
Remme, W.J. and Swedberg, K., Eur. Heart. J., 2001, vol. 22, pp. 1527–1560. doi 10.1053/euhj.2001.2783
Kozlov, I.A. and Kharlamova, I.E., Obshchaya Reanimatologiya, 2009, vol. 5, pp. 89–97. doi 10.15360/1813-9779-2009-1-89
Sawada, Y., Inoue, M., Kanda, T., Sakamaki, T., Tanaka, S., Minamino, N., Nagai, R., and Takeuchi, T., FEBS Lett., 1997, vol. 400, pp. 177–182.
Palmer, S.C., Prickett, T.C., Espiner, E.A., Yandle, T.G., and Richards, A.M., Hypertension, 2009, vol. 54, pp. 612–618. doi 10.1161/Hypertensionaha. 109.135608
Gordon, H. and Williams, M.D., Heart Failure Reviews, 2005, vol. 10, pp. 7–13. doi 10.1007/s10741-005-2343-3
Volpe, M., Int. J. Cardiol., 2014, vol. 176, pp. 630–639. doi 10.1016/j.ijcard.2014.08.032
Hodes, A. and Lichtstein, D., Front. Endocrinol., 2014, vol. 5, p. 201. doi 10.3389/fendo.2014.00201
Nishikimi, T., Minamino, N., Masashi, I., Takeda, Y., Tadokoro, K., Shibasaki, I., Fukuda, H., Horiuchi, Y., Oikawa, S., Ieiri, T., Matsubara, M., and Ishimitsu, T., Heart, 2010, vol. 96, pp. 432–439. doi 10.1136/hrt.2009.178392
de Lemos, J.A., Peacock, W.F., and McCullough, P.A., Rev. Cardiovasc. Med., 2010, vol. 11, pp. 24–34.
Pandey, K.N., J. Am. Soc. Hypertens., 2008, vol. 2, pp. 210–226. doi 10.1016/j.jash.2008.02.001
Kusakabe, M., Cheong, P.L., Nikfar, R., McLennan, I.S., and Koishi, K., J. Cell Biochem., 2008, vol. 103, pp. 311–320. doi 10.1002/jcb.21407
Dubois, C.M., Laprise, M.H., Blanchette, F.B., Gentry, L.E., and Leduc, R., J. Biol. Chem., 1995, vol. 270, pp. 10618–10624.
Lazure, C., Gauthier, D., Jean, F., Boudreault, A., Seidah, N.G., Bennett, H.P., and Hendy, G.N., J. Biol. Chem., 1998, vol. 273, pp. 8572–8580. doi 10.1074/jbc.273.15.8572
Bravo, D.A., Gleason, J.B., Sanchez, R.I., Roth, R.A., and Fuller, R.S., J. Biol. Chem., 1994, vol. 269, pp. 25830–25837.
Komada, M., Hatsuzawa, K., Shibamoto, S., Ito, F., Nakayama, K., and Kitamura, N., FEBS Lett., 1993, vol. 328, pp. 25–29.
Lehmann, M., Rigot, V., Seidah, N.G., Marvaldi, J., and Lissitzky, J.C., Biochem. J., 1996, vol. 317, Pt 3, pp. 803–809. doi 10.1042/bj3170803
Pei, D. and Weiss, S.J., Nature, 1995, vol. 375, pp. 244–247. doi 10.1038/375244a0
Decroly, E., Vandenbranden, M., Ruysschaert, J.M., Cogniaux, J., Jacob, G.S., Howard, S.C., Marshall, G., Kompelli, A., Basak, A., Jean, F., et al., J. Biol. Chem., 1994, vol. 269, pp. 2240–2247.
Morikawa, Y., Barsov, E., and Jones, I., J. Virol., 1993, vol. 67, pp. 3601–3604.
Walker, J.A., Molloy, S.S., Thomas, G., Sakaguchi, T., Yoshida, T., Chambers, T.M., and Kawaoka, Y., J. Virol., 1994, vol. 68, pp. 1213–1218.
Watanabe, M., Hirano, A., Stenglein, S., Nelson, J., Thomas, G., and Wong, T.C., J. Virol., 1995, vol. 69, pp. 3206–3210.
Moehring, J.M., Inocencio, N.M., Robertson, B.J., and Moehring, T.J., J. Biol. Chem., 1993, vol. 268, pp. 2590–2594.
Klimpel, K.R., Molloy, S.S., Thomas, G., and Leppla, S.H., Proc. Natl. Acad. Sci. USA., 1992, vol. 89, pp. 10277–10281.
Tsuneoka, M., Nakayama, K., Hatsuzawa, K., Komada, M., Kitamura, N., and Mekada, E., J. Biol. Chem., 1993, vol. 268, pp. 26461–26465.
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Original Russian Text © N.I. Solovyeva, T.A. Gureeva, O.S. Timoshenko, T.A. Moskvitina, E.V. Kugaevskaya, 2017, published in Biomeditsinskaya Khimiya.
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Solovyeva, N.I., Gureeva, T.A., Timoshenko, O.S. et al. Furin as proprotein convertase and its role in normal and pathological biological processes. Biochem. Moscow Suppl. Ser. B 11, 87–100 (2017). https://doi.org/10.1134/S1990750817020081
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DOI: https://doi.org/10.1134/S1990750817020081