Skip to main content
SpringerLink
Log in

The role of the signaling pathway FGF/FGFR in pancreatic cancer

  • Published:
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Aims and scope Submit manuscript

Abstract

Fibroblast growth factors (FGFs) are signaling molecules with a wide range of actions that are involved in various processes in the body. Specifically for pancreas, FGFs are important for both organogenesis and carcinogenesis. They belong to the factors involved in the interaction between cancer and stromal cells representing a key component in the development of pancreatic cancer. Pathological changes in the FGF/FGFR signaling pathway is a complex process, which depends on type/isoforms of FGF receptors (FGFR) regulating the remodeling effect and subsequent activation of pancreatic cancer cells by FGF. FGFs and their receptors FGFR are considered as potential specific markers and putative targets for treatment of pancreatic cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. American Cancer Society. Cancer Facts & Figures 2016, Atlanta: American Cancer Society, 2016.

  2. Bond-Smith, G., Banga, N., Hammond, T.M., and Imber, C.J., Br. Med. J., 2012, vol. 344, e2476. doi 10.1136/bmj.e2476

    Google Scholar 

  3. Rooman, I. and Real, F.X., Gut, 2012, vol. 61, pp. 449–458. doi 10.1136/gut.2010.235804

    Article  Google Scholar 

  4. Ryan, D.P., Hong, T.S., and Bardeesy, N., N. Eng. J. Med., 2014, vol. 371, pp. 1039–1049. doi 10.1056/NEJMra1404198

    Article  CAS  Google Scholar 

  5. Kong, X., Li, L., Li, Z., and Xie, K., Cytokine Growth Factor Rev., 2012, vol. 23, pp. 343–356. doi 10.1016/j.cytogfr.2012.06.006

    Article  CAS  Google Scholar 

  6. Haugsten, E.M., Wiedlocha, A., Olsnes, S., and Wesche, J., Mol. Cancer Res., 2010, vol. 8, pp. 1439–1452. doi 10.1158/1541-7786.MCR-10-0168

    Article  CAS  Google Scholar 

  7. Neesse, A., Algül, H., Tuveson, D.A., and Gress, T.M., Gut, 2015, vol. 64, pp. 1476–1484. doi 10.1136/gutjnl-2015-309304

    Article  CAS  Google Scholar 

  8. Korc, M., Surgical Oncology Clinics of North America, 1998, vol. 7, pp. 25–41.

    CAS  Google Scholar 

  9. Ornitz, D.M. and Itoh, N., Genome Biol., 2001, vol. 2, no. 3, pp. 1–12.

    Article  Google Scholar 

  10. Schoorlemmer, J. and Goldfarb, M., Curr. Biol., 2001, vol. 11, pp. 793–797.

    Article  CAS  Google Scholar 

  11. Harmer, N.J., Pellegrini, L., Chirgadze, D., Fernandez-Recio, J., and Blundell, T.L., Biochemistry, 2004, vol. 43, pp. 629–640.

    Article  CAS  Google Scholar 

  12. Powers, C.J., McLeskey, S.W., and Wellstein, A., Endocr. Relat. Cancer, 2000, vol. 7, pp. 165–197.

    Article  CAS  Google Scholar 

  13. Trueb, B., Zhuang, L., Taeschler, S., and Wiedemann, M., J. Biol. Chem., 2003, vol. 278, pp. 33857–33865.

    Article  CAS  Google Scholar 

  14. Amann, R. and Trueb, B., Int. J. Mol. Med., 2013, vol. 32, pp. 983–988. doi 10.3892/ijmm.2013.1484

    CAS  Google Scholar 

  15. Ornitz, D.M. and Itoh, N., Wiley Interdiscip. Rev. Dev. Biol., 2015, vol. 4, pp. 215–266. doi 10.1002/wdev.176

    Article  CAS  Google Scholar 

  16. Goetz, R. and Mohammadi, M., Nat. Rev. Mol. Cell. Biol., 2013, vol. 14, pp. 166–180. doi 10.1038/nrm3528

    Article  CAS  Google Scholar 

  17. Eswarakumar, V.P., Lax, I., and Schlessinger, J., Cytokine Growth Factor Rev., 2005, vol. 16, pp. 139–149.

    Article  CAS  Google Scholar 

  18. Ahmad, I., Iwata, T., and Leung, H.Y., Biochim. Biophys. Acta, 2012, vol. 1823, pp. 850–860. doi 10.1016/j.bbamcr.2012.01.004

    Article  CAS  Google Scholar 

  19. Tiong, K.H., Mah, L.Y., and Leong, C.O., Apoptosis, 2013, vol. 18, pp. 1447–1468. doi 10.1007/s10495-013-0886-7

    Article  CAS  Google Scholar 

  20. Holzmann, K., Grunt, T., Heinzle, C., Sampl, S., Steinhoff, H., Reichmann, N., Kleiter, M., Hauck, M., and Marian, B., J. Nucl. Acids, 2012, vol. 2012, 950–508. doi 10.1155/2012/950508

    Article  Google Scholar 

  21. Ishiwata, T., Matsuda, Y., Yamamoto, T., Uchida, E., Korc, M., and Naito, Z., Am. J. Pathol., 2012, vol. 180, pp. 1928–1941. doi 10.1016/j.ajpath.2012.01.020

    Article  CAS  Google Scholar 

  22. Ozawa, F., Friess, H., Tempia-Caliera, A., Kleeff, J., and Büchler, M.W., Teratog. Carcinog. Mutagen., 2001, vol. 21, pp. 27–44.

    Article  CAS  Google Scholar 

  23. Yamanaka, Y., Friess, H., Buchler, M., Beger, H.G., Uchida, E., Onda, M., Kobrin, M.S., and Korc, M., Cancer Res., 1993, vol. 53, pp. 5289–5296.

    CAS  Google Scholar 

  24. Narita, K., Fujii, T., Ishiwata, T., Yamamoto, T., Kawamoto, Y., Kawahara, K., Nakazawa, N., and Naito, Z., Int. J. Oncol., 2009, vol. 34, pp. 355–360.

    CAS  Google Scholar 

  25. Ishiwata, T., Friess, H., Büchler, M.W., Lopez, M.E., and Korc, M., Am. J. Pathol., 1998, vol. 153, pp. 213–222.

    Article  CAS  Google Scholar 

  26. Nomura, S., Yoshitomi, H., Takano, S., Shida, T., Kobayashi, S., Ohtsuka, M., Kimura, F., Shimizu, H., Yoshidome, H., Kato, A., and Miyazaki, M., Br. J. Canc., 2008, vol. 99, pp. 305–313. doi 10.1038/sj.bjc.6604473

    Article  CAS  Google Scholar 

  27. Hebrok, M., Mechanisms of Development, 2003, vol. 120, pp. 45–57.

    Article  CAS  Google Scholar 

  28. Dichmann, D.S., Miller, C.P., Jensen, J., Scott Heller, R., and Serup, P., Dev. Dyn., 2003, vol. 226, pp. 663–674.

    Article  CAS  Google Scholar 

  29. Liu, Z., Neiss, N., Zhou, S., Henne-Bruns, D., Korc, M., Bachem, M., and Kornmann, M., Cancer Res., 2007, vol. 67, pp. 2712–2719.

    Article  CAS  Google Scholar 

  30. Coleman, S.J., Chioni, A.M., Ghallab, M., Anderson, R.K., Lemoine, N.R., Kocher, H.M., and Grose, R.P., EMBO Mol. Med., 2014, vol. 6, pp. 467–481. doi 10.1002/emmm.201302698

    Article  CAS  Google Scholar 

  31. Reilly, J.F. and Maher, P.A., J. Cell Biol., 2001, vol. 152, pp. 1307–1312.

    Article  CAS  Google Scholar 

  32. Lafitte, M., Moranvillier, I., Garcia, S., Peuchant, E., Iovanna, J., Rousseau, B., Dubus, P., Guyonnet-Dupérat, V., Belleannée, G., Ramos, J., Bedel, A., de Verneuil, H., Moreau-Gaudry, F., and Dabernat, S., Mol. Cancer, 2013, vol. 12, p. 83. doi 10.1186/1476-4598-12-83

    Article  CAS  Google Scholar 

  33. Hebrok, M., Kim, S.K., and Melton, D.A., Genes Dev., 1998, vol. 12, pp. 1705–1713.

    Article  CAS  Google Scholar 

  34. Rachagani, S., Macha, M.A., Ponnusamy, M.P., Haridas, D., Kaur, S., Jain, M., and Batra, S.K., Carcinogenesis, 2012, vol. 33, pp. 1953–1964. doi 10.1093/carcin/bgs225

    Article  CAS  Google Scholar 

  35. Niu, J., Chang, Z., Peng, B., Xia, Q., Lu, W., Huang, P., Tsao, M.S., and Chiao, P.J., J. Biol. Chem., 2007, vol. 282, pp. 6001–6011.

    Article  CAS  Google Scholar 

  36. Cho, K., Ishiwata, T., Uchida, E., Nakazawa, N., Korc, M., Naito, Z., and Tajiri, T., Am. J. Pathol., 2007, vol. 170, pp. 1964–1974.

    Article  CAS  Google Scholar 

  37. Matsuda, Y., Yoshimura, H., Suzuki, T., Uchida, E., Naito, Z., and Ishiwata, T., Cancer Sci., 2014, vol. 105, pp. 1212–1219. doi 10.1111/cas.12470

    Article  CAS  Google Scholar 

  38. Tian, X., Chen, G., Zhou, S., Henne-Bruns, D., Bachem, M., and Kornmann, M., Hepatogastroenterology, 2012, vol. 59, no. 117, pp. 1604–1608. doi 10.5754/hge10366

    CAS  Google Scholar 

  39. Shirasawa, S., Yoshie, S., Yokoyama, T., Tomotsune, D., Yue, F., and Sasaki, K., Stem Cells Dev., 2011, vol. 20, no. 6, pp. 1071–1078. doi 10.1089/scd.2010.0185

    Article  CAS  Google Scholar 

  40. Seymour, P.A., Rev. Diabet. Stud., 2014, vol. 11, no. 1, pp. 51–83. doi 10.1900/RDS.2014.11.51

    Article  Google Scholar 

  41. Taeger, J., Moser, C., Hellerbrand, C., Mycielska, M.E., Glockzin, G., Schlitt, H.J., Geissler, E.K., Stoeltzing, O., and Lang, S.A., Mol. Cancer Ther., 2011, vol. 10, no. 11, pp. 2157–2167. doi 10.1158/1535-7163.MCT-11-0312

    Article  CAS  Google Scholar 

  42. Tassi, E. and Wellstein, A., Cancer Res. Treat., 2006, vol. 38, no. 4, pp. 189–197. doi 10.4143/crt.2006.38.4.189

    Article  Google Scholar 

  43. Zhou, L., Yao, L.T., Liang, Z.Y., Zhou, W.X., You, L., Shao, Q.Q., Huang, S., Guo, J.C., and Zhao, Y.P., Internat. J. Clin. Exp. Pathol., 2015, vol. 8, no. 11, pp. 14640–14648.

    CAS  Google Scholar 

  44. Kostrzewa, M. and Müller, U., Mammalian Genome: Off. J. Internat. Mammalian Genome Soc., 1998, vol. 9, no. 2, pp. 131–135.

    Article  CAS  Google Scholar 

  45. Bange, J., Prechtl, D., Cheburkin, Y., Specht, K., Harbeck, N., Schmitt, M., Knyazeva, T., Müller, S., Gärtner, S., Sures, I., Wang, H., Imyanitov, E., Häring, H.U., Knayzev, P., Iacobelli, S., Höfler, H., and Ullrich, A., Cancer Res., 2002, vol. 62, no. 3, pp. 840–847.

    CAS  Google Scholar 

  46. Wang, J., Stockton, D.W., and Ittmann, M., Clin. Cancer Res.: Off. J. Am. Ass. Cancer Res., 2004, vol. 10, 18 Pt 1, pp. 6169–6178.

    Google Scholar 

  47. da Costa Andrade, V.C., Parise, O., Jr, Hors, C.P., de Melo Martins, P.C., Silva, A.P., and Garicochea, B., Exp. Mol. Pathol., 2007, vol. 82, no. 1, pp. 53–57.

    Article  Google Scholar 

  48. Serra, S., Zheng, L., Hassan, M., Phan, A.T., Woodhouse, L.J., Yao, J.C., Ezzat, S., and Asa, S.L., Cancer Res., 2012, vol. 72, no. 22, pp. 5683–5691. doi 10.1158/0008-5472.CAN-12-2102

    Article  CAS  Google Scholar 

  49. Motoda, N., Matsuda, Y., Onda, M., Ishiwata, T., Uchida, E., and Naito, Z., Internat. J. Oncol., 2011, vol. 38, no. 1, pp. 133–143.

    CAS  Google Scholar 

  50. Xu, Z., Pothula, S.P., Wilson, J.S., and Apte, M.V., W. J. Gastroenterol., 2014, vol. 20, no. 32, pp. 11216–11229. doi 10.3748/wjg.v20.i32.11216

    Article  Google Scholar 

  51. Tassi, E. and Wellstein, A., Semin. Oncol., 2006, vol. 6, no. 11, pp. 50–56.

    Article  Google Scholar 

  52. Zhang, X., Nie, D., and Chakrabarty, S., Front. Biosci. (Landmark Ed.), 2010, vol. 15, pp. 151–165.

    Article  CAS  Google Scholar 

  53. Compagni, A., Wilgenbus, P., Impagnatiello, M.A., Cotton, M., and Christofori, G., Cancer Res., 2000, vol. 60, no. 24, pp. 7163–7169.

    CAS  Google Scholar 

  54. Mateescu, G., Comănescu, M., Mehedinţi, R., Niculescu, Z., Bold, A., Panduru, L., and Cernea, D., Rom. J. Morphol. Embryol., 2010, vol. 51, no. 2, pp. 303–307.

    Google Scholar 

  55. Abuharbeid, S., Czubayko, F., and Aigner, A., Int. J. Biochem. Cell Biol., 2006, vol. 38, no. 9, pp. 1463–1468.

    Article  CAS  Google Scholar 

  56. Nandy, D. and Mukhopadhyay, D., Cancers (Basel), 2011, vol. 3, no. 1, pp. 841–871. doi 10.3390/cancers3010841

    Article  CAS  Google Scholar 

  57. Tassi, E., Henke, R.T., Bowden, E.T., Swift, M.R., Kodack, D.P., Kuo, A.H., Maitra, A., and Wellstein, A., Cancer Res., 2006, vol. 66, no. 2, pp. 1191–1198.

    Article  CAS  Google Scholar 

  58. Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A.A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J.P., Fischer, C., Rigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, J., Segura, I., Gueguen, G., Bordes, M.F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J.M., Katsuma, S., Schaeffer, P., Yayon, A., Van Schepdael, A., Schwalbe, H., Gervasio, F.L., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J.M., and Carmeliet, P., Cancer Cell, 2013, vol. 23, no. 4, pp. 477–488. doi 10.1016/j.ccr.2013.02.019

    Article  CAS  Google Scholar 

  59. Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer. https://clinicaltrials.gov/ct2/show/NCT0257550.

Download references

Author information

Authors and Affiliations

  1. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    D. A. Gnatenko, E. P. Kopantsev & E. D. Sverdlov

Authors
  1. D. A. Gnatenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. P. Kopantsev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. D. Sverdlov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. A. Gnatenko.

Additional information

Original Russian Text © D.A. Gnatenko, E.P. Kopantsev, E.D. Sverdlov, 2017, published in Biomeditsinskaya Khimiya.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gnatenko, D.A., Kopantsev, E.P. & Sverdlov, E.D. The role of the signaling pathway FGF/FGFR in pancreatic cancer. Biochem. Moscow Suppl. Ser. B 11, 101–110 (2017). https://doi.org/10.1134/S1990750817020032

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1990750817020032

Keywords

Search

Navigation