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Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients

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Abstract

Ongoing studies carried out worldwide using banks of tumor and non-tumor samples give evidence that perspective markers predicting response of individual patients to intended radiation therapy may be found among some apoptotic indexes, spectrum of specialized proteins, and DNA-based microarray molecular profiling analysis as well determination of single nucleotide polymorphisms in genome of the patients. In the last years there is increasing interest in radiogenomics and characterization of gene expression profiles by DNA (micro)array technique that can predict radioresponse of tumor and non-tumor tissues. So far there are only a few reliable molecular markers predicting response of tumor and non-tumor tissues to radiation.

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References

  1. Souhami, R. and Tobias, J., Rak i ego lechenie (Cancer and its Management), Moscow: BINOM. Laboratoriya Znaniy, 2009.

    Google Scholar 

  2. Delaney, G., Jacob, S., Featherstone, C., and Barton, M., Cancer, 2005, vol. 104, pp. 1129–1137.

    Article  Google Scholar 

  3. Desar, I.M.E., van Herpen, C.M.I., van Laarhoven, H.W.N., Barentsz, J.O., Oyen, W.J.G., and van der Graaf, W.T.A., Cancer Treatment Reviews, 2009, vol. 35, pp. 309–321.

    Article  CAS  Google Scholar 

  4. IAEA-TECDOC-1297, Predictive assays and their role in selection of radiation as the therapeutic modality, Vienna: International Nuclear Information System Clearinghouse, International Atomic Energy Agency, 2002.

    Google Scholar 

  5. West, C.M.L., McKay, M.J., Holscher, T., Holscher, T., Baumann, M., Stratford, I.J., Bristow, R.G., Iwakawa, M., Imai, T., Zingde, S.M., Anscher, M.S., Bourhis, J., Begg, A.C., Haustermans, K., Bentzen, S.M., and Hendry, J.H., Int. J. Rad. Oncol. Biol. Phys., 2005, vol. 62, pp. 1264–1273.

    Article  CAS  Google Scholar 

  6. Hiotis, K., Ye, W., Sposto, R., and Skinner, K.A., Cancer, 2005, vol. 103, pp. 892–899.

    Article  Google Scholar 

  7. Mackay, R.I. and Hendry, J.H., Radiother. Oncol., 1999, vol. 50, pp. 67–75.

    Article  CAS  Google Scholar 

  8. Ivanov, S.D., Vopr. Onkol., 2000, vol. 46, pp. 129–135.

    CAS  Google Scholar 

  9. Ivanov, S.D., Yashmanov, V.A., Korytova, L.I., Khazova, T.V., and Arzumanov, A.S., Vopr. Onkol., 2003, vol. 49, pp. 601–607.

    CAS  Google Scholar 

  10. Ivanov, S.D., Korytova, L.I., Yamshanov, V.A., Il’in, N.V., and Sibirtsev, V.S., J. Exp. Clin. Cancer Res., 1997, vol. 16, pp. 413–418.

    CAS  Google Scholar 

  11. Mayers, C., Panzarella, T., and Tannock, I.F., Cancer, 2001, vol. 91, pp. 2246–2257.

    Article  CAS  Google Scholar 

  12. Saarto, T., Blomqvist, C., Rissanen, P., Auvinen, A., and Elomaa, I., Br. J. Cancer, 1997, vol. 75, pp. 301–305.

    Article  CAS  Google Scholar 

  13. Ivanov, S.D., Vopr. Onkol., 2008, vol. 54, pp. 483–489.

    CAS  Google Scholar 

  14. Rodel, C., Grabenbauer, G., Rodel, F., Birkenhake, S., Kühn, R., Martus, P., Zörcher, T., Fürsich, D., Papadopoulos, T., Dunst, J., Schrott, K.M., and Sauer, R., Int. J. Radiation Oncology Biol. Phys., 2000, vol. 46, pp. 1213–1221.

    Article  CAS  Google Scholar 

  15. Ho, A.Y., Atencio, D.P., Peters, S., Stock, R.G., Formenti, S.C., Cesaretti, J.A., Green, S., Haffty, B., Drumea, K., Leitzin, L., Kuten, A., Azria, D., Ozsahin, M., Overgaard, J., Andreassen, C.N., Trop, C.S., Park, J., Rosenstein, B.S., Int. J. Rad. Oncol. Biol. Phys., 2006, vol. 65, pp. 646–655.

    Article  Google Scholar 

  16. Ramakrishnan, N. and Brenner, D., Radiat. Res., 2008, vol. 170, pp. 666–675.

    Article  Google Scholar 

  17. Barsukov, Yu.A., Tkachev, S.I., Knysh, V.I., Oltarzhevskaya, N.D., Korovina, M.A., Yarmonenko, S.P., Vainson, A.A., Perevoshchikov, A.G., Nikolaev, A.V., Gradyushko, A.T., Kutatelidze, T.O., Vlassov, O.A., Malikhov, A.G., Tamrazov, R.I., Kuz’michev. D.V., Aliev, V.A., and Mamedli, Z.Z., Vopr. Onkol., 2008, vol. 54, pp. 350–353.

    Google Scholar 

  18. Oppitz, U., Baier, K., Wulf, J., Schakowski, R., and Flentje, M., Int. J. Radiat. Biol., 2001, vol. 77, pp. 105–110.

    Article  CAS  Google Scholar 

  19. Kravtsov, V.D., Eur. J. Cancer, 1994, vol. 30A, pp. 1564–1570.

    Article  CAS  Google Scholar 

  20. Ivanov, S.D., Maslyukova, E.A., Karelin, M.I., Yamshanov, V.A., and Kovan’ko, E.G., Vopr. Onkol., 2006, vol. 52, pp. 565–570.

    CAS  Google Scholar 

  21. Holst, C.R., Nuovo, G.J., Esteller, M., Chew, K., Baylin, S.B., Herman, J.G., and Tilsty, T.D., Cancer Res., 2003, vol. 63, pp. 1596–1601.

    CAS  Google Scholar 

  22. Yan, P.S., Venkataramu, C., Ibrahim, A., Liu, J.C., Shen, R.Z., Diaz, N.M., Centeno, B., Weber, F., Leu, Y.W., Shapiro, C.L., Eng, C., Yeatman, T.J., and Huang, T.H., Clin. Cancer Res., 2006, vol. 12, pp. 6626–6636.

    Article  CAS  Google Scholar 

  23. Meeker, A.K., Hicks, J.L., Gabrielson, E., Strauss, W.M., De Marzo, A.M., and Argani, P., Am. J. Pathol., 2004, vol. 164, pp. 925–935.

    Article  Google Scholar 

  24. Khan, S.A., Sanchdeva, A., Naim, S., Meguid, M.M., Marx, W., Simon, H., Halverson, J.D., and Numann, P.J., Cancer Epidemiol. Biomarker Prev., 1999, vol. 8, pp. 867–872.

    CAS  Google Scholar 

  25. Widschwendter, M., Berger, J., Daxenbichler, G., Muller-Holzner, E., Widschwendter, A., Mayr, A., Marth, C., and Zeimet, A.G., Cancer Res., 1997, vol. 57, pp. 4158–4161.

    CAS  Google Scholar 

  26. Tripathi, A., King, C., de la Morenas, A., Perry, V.K., Burke, B., Antoine, G.A., Hirsch, E.F., Kavanah, M., Mendez, J., Stone, M., Gerry, N.P., Lenburg, M.E., and Rosenberg, C.L., Int. J. Cancer, 2008, vol. 122, pp. 1557–1566.

    Article  CAS  Google Scholar 

  27. Schummer, M., Beatty, D., and Urban, N., Ann. N.Y. Acad. Sci., 2010, vol. 1210, pp. 78–85.

    Article  CAS  Google Scholar 

  28. Pirzkall, A., McKnight, T.R., Graves, E.E., Carol, M.P., Sneed, P.K., Wara, W.W., Nelson, S.J., Verhey, L.J., and Larson, D.A., Int. J. Radiat. Oncol. Biol. Phys., 2001, vol. 50, pp. 915–928.

    Article  CAS  Google Scholar 

  29. Ivanov, S.D., Remizova, I.V., Kovan’ko, E.G., Gubareva, A.V., and Komar, V.E., Byull. Eksper. Biol. Med., 1990, vol. 109, pp. 296–299.

    CAS  Google Scholar 

  30. Dillon, N., Biol. Cell, 2004, vol. 96, pp. 631–637.

    Article  CAS  Google Scholar 

  31. Ivanov, S.D., Bespalov, V.G., Kovanko, E.G., Aleksandrov, V.A., Yamshanov, V.A., Eur. J. Cancer, 2002, vol. 38, Suppl. 3, p. 119.

    Article  Google Scholar 

  32. Ivanov, S.D., Yamshanov, V.A., Kovan’ko, E.G., Vorobtsova, V.A., Poroshina, T.E., and Bershtein, L.M., Byull. Eksper. Biol. Med., 2006, vol. 137, pp. 654–658.

    Google Scholar 

  33. Gabelova, A., Farkasova, T., Gurska, S., Machackova, Z., Lukacko, P., and Witkovsky, V., Neoplasma, 2008, vol. 55, pp. 182–191.

    CAS  Google Scholar 

  34. Krishnamurthy, V., Gunalan, G., Haridas, S., and Thangamani, V., Current Sci., 2008, vol. 94, pp. 1195–1199.

    CAS  Google Scholar 

  35. Mal’tseva, V.N., Avkhacheva, N.V., Santalov, B.F., and Safronova, V.G., Tsitologiya, 2006, vol. 48, pp. 1000–1009.

    Google Scholar 

  36. Devitt, J.J., Maranon, D.G., Ehrhart, E.J., Bachand, A.M., Lana, S.E., and LaRue, S.M., Cytogenet. Genome Res., 2009, vol. 124, pp. 12–18.

    Article  CAS  Google Scholar 

  37. Monakhov, A.S., Semiglazov, V.F., Vagner, R.I., Gulyaev, A.V., Anisimov, V.V., and Barchuk, A.S., Vopr. Onkol., 2008, vol. 54, pp. 565–572.

    CAS  Google Scholar 

  38. Severin, E., Greve, B., Pascger, E., Wedemeyer, N., Hacker-Klom, U., Silling, G., Kienast, J., Willich, N., and Gohde, W., Int. J. Radiat. Oncol. Biol. Phys., 2006, vol. 64, pp. 242–250.

    Article  Google Scholar 

  39. Hicks, R.J. and Manus, M.P., J. Nucl. Med., 2003, vol. 44, pp. 30–32.

    Google Scholar 

  40. Skvortsova, T.Yu., Brodskaya, Z.L., Malakhova, E.S., and Medvedev, S.V., Luchevaya Diagnostika Terapiya, 2010, vol. 1, pp. 5–17.

    Google Scholar 

  41. Miwa, K., Shinoda, J., Yano, H., Okumura, A., Iwama, T., Nakashima, T., Sakai, N. J. Neurol. Nuerosurg. Psychiatry, 2004, vol. 75, pp. 1457–1462.

    Article  CAS  Google Scholar 

  42. Seitz, I.F., in Patogeneticheskie osnovy diagnostiki i lecheniya zlokachestvennykh opukholei (Pathogenic Principles of Diagnostics and Treatment of Malignant Tumors), Leningrad: Meditsina, 1976, pp. 3–17.

    Google Scholar 

  43. Xiang, Z.-L., Zang, Z.-C., Tang, Z.-Y., Fan, J., He, J., Zeng, H.-Y., and Zhu, X.D., The Oncologist, 2011, vol. 16, pp. 1028–1039.

    Article  CAS  Google Scholar 

  44. Storto, G., Nicolai, E., and Salvatore, M., J. Nucl. Med. Imaging, 2009, vol. 53, pp. 167–180.

    CAS  Google Scholar 

  45. Everaert, H., Hoorens, A., Vanhove, C., Sermeus, A., Ceulemans, G., Engels, B., Vermeersch, M., Verellen, D., Urbain, D., Storme, G., and De Ridder, M., Int. J. Rad. Oncol. Biol. Phys., 2011, vol. 80, pp. 91–96.

    Article  Google Scholar 

  46. Hahn, K.A., Richardson, R.C., Hahn, E.A., and Chrismas, C.L., Vet. Pathol., 1994, vol. 31, pp. 528–540.

    Article  CAS  Google Scholar 

  47. Thomas, R., Smith, K.C., Galibert, F., and Breen, M., Br. J. Cancer., 2003, vol. 89, pp. 1530–1537.

    Article  CAS  Google Scholar 

  48. Chin, L. and Gray, J.W., Nature, 2008, vol. 452, pp. 553–563.

    Article  CAS  Google Scholar 

  49. Swanton, C. and Caldas, C., Ann. N.Y. Acad. Sci., 2010, vol. 1210, pp. 34–44.

    Article  Google Scholar 

  50. Sakai, Y., Honda, M., Fujinaga, H., Tatsumi, I., Mizukoshi, E., Nakamoto, Y., and Kaneko, S., Cancer Res., 2008, vol. 68, pp. 10267–10279.

    Article  CAS  Google Scholar 

  51. Showe, M.K., Vachani, A., Kossenkov, A.V., Yousef, M., Nichols, C., Nikonova, E.V., Chang, C., Kucharczuk, J., Bao Tran, B., Wakeam, E., Yie, T.A., Speicher, D., Rom, W.N., Albelda, S., and Showe, L.C., Cancer Res., 2009, vol. 69, pp. 9202–9210.

    Article  CAS  Google Scholar 

  52. Honda, M., Sakai, Y., Yamashata, T., Yamashita, T., Sakai, A., Mizukoshi, E., Nakamoto, Y., Tatsumi, I., Yoshitaka, M.Y., Hiroshi, T.H., Kaneko, S., and Hokuriku, O., Biochem. Biophys. Res. Commun., 2010, vol. 400, pp. 7–15.

    Article  CAS  Google Scholar 

  53. M’kacher, R., Bennaceur-Griscelli, A., Girinsky, T., Koscielny, S., Delhommeau, F., Dossou, J., Violot, D., Leclerq, E., Courtier, M.H., Beron-Gaillard, N., Assaf, E., Ribrag, V., Bouhis, J., Fenneux, D., Bernheim, A., Parmentier, C., and Carde, P., Int. J. Rad. Oncol. Biol. Phys., 2007, vol. 68, pp. 465–471.

    Article  Google Scholar 

  54. van de Vijver, M., The Oncologist, 2005, vol. 10, Suppl. 2, pp. 30–34.

    Article  Google Scholar 

  55. Pramana, J., van den Brekel, M.W.M., van Velthuysen, M.-L.F., Wesseks, L.F.A., van Nuyten, D.S., Hofland, I., Atsma, D., Pimentel, N., Hoebers, F.J.P., Rasch, C.R.N., Begg, A.C., Int. J. Rad. Oncol. Biol. Phys., 2007, vol. 69, pp. 1544–1552.

    Article  CAS  Google Scholar 

  56. Theurillat, J.-P., Zurrer-Hardi, U., Varga, Z., Barghorn, A., Saller, E., Frei, C., Storz, M., Behnke S., Seifert B., Fehr M., Fink D., Rageth C., Linsenmeier C., Pestalozzi B., Chen, Y.-T., Knuth, A., Jager, D., and Moch, H., Int. J. Cancer, 2008, vol. 122, pp. 1585–1591.

    Article  CAS  Google Scholar 

  57. Nishizuka, S., Charboneau, L., Young, L., Major, S., Reinhold, W.C., Waltham, M., Kouros-Mehr, H., Bussey, K. J., Lee, J.K., Espina, V., Munson, P.J., Petricoin III, E., Liotta, L.A., and Weinstein, J.N., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, pp. 14229–14234.

    Article  CAS  Google Scholar 

  58. Sawyers, C.L., Nature, 2008, vol. 452, pp. 548–552.

    Article  CAS  Google Scholar 

  59. van’t Veerr, L. and Bernards, R., Nature, 2008, vol. 452, pp. 564–570.

    Article  Google Scholar 

  60. Weiss, C., von Romer, F., Capalbo, G., Ott, O.J., Wittlinger, M., Krause, S.F., Sauer, R., Rodel, C., and Rodel, F., Int. J. Radiat. Oncol. Biol. Phys., 2009, vol. 74, pp. 1455–1460.

    Article  CAS  Google Scholar 

  61. Capalbo, G., Dittman, K., Weiss, C., Reichart, S., Hausmann, E., Rodel, C., and Rodel, F., Int. J. Rad. Oncol. Biol. Phys., 2010, vol. 77, pp. 226–234.

    Article  CAS  Google Scholar 

  62. Lee, H.-J., Lee, Y.-J., Kang, C.-M., Bae, S., Jeoung, D., Jang, J.-J., Lee, S.-S., Cho, C.-K., and Lee, Y.-S., Radiation Res., 2008, vol. 170, pp. 579–590.

    Article  CAS  Google Scholar 

  63. West, C.M.L., Elliott, R.M., and Burnet, N.G., Clin. Oncol., 2007, vol. 19, pp. 470–480.

    Article  CAS  Google Scholar 

  64. Nasedkina, T.V., Zharinov, V.S., Isaeva, E.A., Mityaeva, O.N., Yurasov, R.A., Surzhikov, S.A., Turigin, A.Yu., Rubina, A.Yu., Karachunskii, A.I., Gartenhaus, R.B., and Mirzabekov, A.D., Clin. Cancer Res., 2003, vol. 9, pp. 5620–5629.

    CAS  Google Scholar 

  65. van de Vijver, M.J., He, Y.D., van’t Veer, L.J., Dai, H., Hart, A.A.M., Voskuil, D.W., Schreiber, G.J., Peterse, J.L., Roberts, C., Marton, M.J., Parrish, M., Atsma, D., Witteveen, A., Glas, A. Delahave, L., vander Velde, T., Baterlink, H., Rodenhuis, S., Rutgers, E.T., Friend, S.H., and Bernards, R., N. Engl. J. Med., 2002, vol. 347, pp. 1999–2009.

    Article  Google Scholar 

  66. Jelonek, K., Gdowicz-Klosok, A., Pietrowska, M., Borkowska, M., Korfanty, J., Rzeszowska-Wolny, J., and Widlak, P., J. Appl. Genet., 2010, vol. 51, pp. 343–352.

    Article  CAS  Google Scholar 

  67. Espina, V., Mehta, A.I., Winters, M.E., Calvert, V., Wulfkuhle, J., Petricoin, E.F., and Liotta, L.A., Proteomics, 2003, vol. 3, pp. 2091–2100.

    Article  CAS  Google Scholar 

  68. Buffa, F.M., Bentzen, S.M., Daley, F.M., Dische, S., Saunder, M.I., Richman, P.I., and Wilson, G.D., Clin. Cancer Res., 2004, vol. 10, pp. 3745–3754.

    Article  CAS  Google Scholar 

  69. Eriksen, J.G., Buffa, F.M., Alsner, J., Steiniche, T., Bentzen, S.M., and Overgaard, J., Radiother. Oncol., 2004, vol. 72, pp. 275–282.

    Article  CAS  Google Scholar 

  70. Streffer, C., Bauch, T.H. Stuben, G., Zolzer, F., and Muller, W.-U., Progr. Radio-Oncology, 1998, vol. 6, pp. 501–507.

    Google Scholar 

  71. Borgmann, K., Hoeller, U., Nowack, S., Bernhard, M., Roper, B., Brackrock, S., Petersen, C., Szymczak, S., Ziegler, A., Feyer, P., Alberti, W., and Dikomey, E., Int. J. Radiation Oncology Biol. Phys., 2008, vol. 71, pp. 256–264.

    Article  Google Scholar 

  72. Ozsahin, M., Crompton, N.E., Gourgou, S., Kramar, A., Li, L., Shi, Y., Sozzi, W.J., Zouhair, A., Mirimanoff, R.O., and Azria, D., Clin. Cancer Res., 2005, vol. 11, pp. 7426–7433.

    Article  CAS  Google Scholar 

  73. Azria, D., Ozsahin, M., Kramar, A., Peters, S., Atencio, D.P., Crompton, N.E.A., Momex, F., Pelegrin, A., Dubois, J.-B., Mirimanoff, R.-O., and Rosenstein, B.S., Clin. Cancer Res., 2008, vol. 14, pp. 6284–6288.

    Article  CAS  Google Scholar 

  74. Mangoni, M, Bisanzi, S., Carozzi, F., Sani, C., Biti, G., Livi, L., Barletta, E., Constantini, AS., and Gorini, G., Int. J. Rad. Oncol. Biol. Phys., 2011, vol. 81, pp. 52–58.

    Article  CAS  Google Scholar 

  75. Brenner, D.J., Radiat. Res., 2008, vol. 170, p. 668.

    Google Scholar 

  76. Paul, S., Barker, C.A., Turner, H.C., McLane, A., Wolden, S.L., and Amundson, S.A., Radiation Res., 2011, vol. 187, pp. 257–265.

    Article  Google Scholar 

  77. Damaraju, S., Sehrawat, B.S., Carandang, D., Rashmi Penugonde, R., Greinerb, R., and Parliament, M., Radiat. Res., 2008, vol. 170, pp. 671–672.

    Google Scholar 

  78. Rosenstein, B.S., Radiat. Res., 2008, vol. 170, pp. 670–671.

    Google Scholar 

  79. Iwakawa, M., Imai, T., Harada, Y., Ban, S., Michikawa, Y., and Saegusa, K., Nippon Igaku Hoshasen Gakkai Zasshi, 2002, vol. 62, pp. 484–489.

    Google Scholar 

  80. Iwakawa, M., Imai, T., Ohta, T., Oohira, C., Tanaka, H., Tsuji, A., Ishikawa, A., and Imai, T., J. Radiat. Res., 2004, vol. 45, pp. 423–433.

    Article  CAS  Google Scholar 

  81. Imai, T. and Iwakawa, M., Radiat. Res., 2008, vol. 170, pp. 674.

    Google Scholar 

  82. Zhou, F.-X., Liao, Z.K., Dai, J., Xiong, J., Xie, C.H., Luo, Z.G., Liu, S.Q., and Zhou, Y.F., Biochem. Biophys. Res. Commun., 2007, vol. 354, pp. 353–356.

    Article  Google Scholar 

  83. Ji, X.M., Xie, C.H., Fang, H., Zhou, F.-X., Zhang, W.-J., Zhang, M.-S., and Zhou, Y.-F., Acta Pharmacol. Sin., 2006, vol. 27, pp. 1185–1191.

    Article  CAS  Google Scholar 

  84. Kang, C.-M., Cho, H.-N., Ahn, J.-M., Lee, S.-S., Jeoung, D.-I., Cho, C.-K., Bae, S., Lee, S.-J., and Lee, Y.-S., Carcinogenesis, 2004, vol. 25, pp. 123–132.

    Article  Google Scholar 

  85. Zhou, F.-X., Xiong, J., Luo, Z.-G., Dai, J., Yu, H.-J., Liao, Z.-K., Lei, Y., Xie, C.-H., and Zhou, Y.-F., Radiation Res., 2010, vol. 174, pp. 550–557.

    Article  CAS  Google Scholar 

  86. Potselueva, M.M., Pustovid’ko, A.V., Kovaleva, E.V., Shatalin, Yu.V., and Evtodienko, Yu.V., Tsitologiya, 2005, vol. 47, pp. 57–63.

    CAS  Google Scholar 

  87. Gorozhanskaya, E.G., Klin. Lab. Diagn., 2010, no. 6, pp. 28–44.

    Google Scholar 

  88. Ivanov, S.D., Yamshanov, V.A., and Maslyukova, E.A., Rus. Patent no. 2319963, Byull. Izobret., 2008, no. 8, pp. 1–5.

    Google Scholar 

  89. Ivanov, S.D., Proc. III Eurasian Congress on Medical Physics and Engineering “Medical Physics 2010,” 2010, vol. 2, pp. 247–249.

    Google Scholar 

  90. Ivanov, S., Korytova, L., Yamshanov, V., Ilyn, N., Akimov, A., Sibirtsev, V., and Shust, V., Progr. Radio-Oncol., 1998, vol. 6, pp. 569–573.

    Google Scholar 

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Original Russian Text © S.D. Ivanov, 2013, published in Biomeditsinskaya Khimiya.

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Ivanov, S.D. Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients. Biochem. Moscow Suppl. Ser. B 7, 212–221 (2013). https://doi.org/10.1134/S1990750813030074

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