Skip to main content
SpringerLink
Log in

The influence of ethanol-metabolizing systems on the intensity of lipid peroxidation processes in the gastrointestinal tract of rats

  • Published:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry Aims and scope Submit manuscript

Abstract

The effects of some ethanol-metabolizing systems (aldehyde dehydrogenase, catalase, cytochrome P450 2E1) on activation of lipid peroxidation (LPO) processes in the gastrointestinal tract of rats have been studied using inhibitors of these systems. The intensity of LPO processes was evaluated by thiobarbituric acid-reactive substances and chemiluminiscence intensity. It was found, that acetadehyde metabolism plays the major role in the LPO induction in epithelium of the rat gastrointestinal tract.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Totnwall, M., Smith, G., and Barreto, J., Dig. Dis. Science, 1993, vol. 38, pp. 2294–2298.

    Article  Google Scholar 

  2. Bagchi, D., Carryl, O.R., Tran, M.X., Krohn, R.L., Bagchi, D.J., Garg, A., Bagchi, M., Mitra, S., and Stohs, S.J., J. Appl. Toxicology, 1998, vol. 18, no. 1, pp. 3–13.

    Article  CAS  Google Scholar 

  3. Lucas, D., Alcohol and Alcoholism, 2001, vol. 36, no. 5, p. 440.

  4. Mari, M. and Cederbaum, A., Alcohol and Alcoholism, 2001, vol. 36, no. 5, p. 439.

  5. Seitz, H. and Poschl, G., Alcohol and Alcoholism, 1997, vol. 32, no. 5, pp. 543–549.

    Article  CAS  Google Scholar 

  6. Seitz, H., Simanovsky, U., and Garzon, F., Gastroenterology, 1990, vol. 98, pp. 406–413.

    CAS  Google Scholar 

  7. Placer, Z.A., Cushman, L., and Johnson, B.C., Anal. Biochem., 1966, vol. 18, pp. 515–519.

    Google Scholar 

  8. Vladimirov, Yu.A. and Archakov, A.I., Perekisnoe okislenie lipidov v biomembranakh (Lipid Peroxidation in Biomembranes), Moscow: Nauka, 1972.

    Google Scholar 

  9. Pronko, P.S., Kuzmich, A.B., and Abakumov, G.Z., Ukr. Biokhim. Z., 1999, vol. 71, no. 4, pp. 75–79.

    Google Scholar 

  10. Kinoshita, H., Ijiri, I., and Ameno, S., Alcoholism: Clinical and Experimental Research, 1996, vol. 20, pp. 510–513.

    Article  CAS  Google Scholar 

  11. Kinoshita, H., Ameno, S., and Kubota, T., Alcohol and Alcoholism, 2001, vol. 36, no. 5, pp. 377–380.

    Article  CAS  Google Scholar 

  12. Izbeki, F., Wittmann, T., Csati, S., Jeszenszky, E., and Lonovics, J., Alcohol and Alcoholism, 2001, vol. 36, pp. 304–308.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Medical University, ul. Gorkogo 80, Grodno, 230015, Belarus

    N. E. Petushok & S. P. Pronko

  2. Institute of Pharmacology and Biochemistry, National Academy of Sciences of Belarus, Grodno, Belarus

    T. Ch. Grohovskaya & N. G. Melnichenko

Authors
  1. N. E. Petushok
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Ch. Grohovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. G. Melnichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. P. Pronko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. E. Petushok.

Additional information

Original Russian Text © N.E. Petushok, T.Ch. Grohovskaya, N.G. Melnichenko, S.P. Pronko, 2012, published in Biomeditsinskaya Khimiya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petushok, N.E., Grohovskaya, T.C., Melnichenko, N.G. et al. The influence of ethanol-metabolizing systems on the intensity of lipid peroxidation processes in the gastrointestinal tract of rats. Biochem. Moscow Suppl. Ser. B 6, 156–158 (2012). https://doi.org/10.1134/S1990750812020084

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1990750812020084

Keywords

Search

Navigation