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Conotoxins: From the biodiversity of gastropods to new drugs

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Abstract

The review describes general trends in research of conotoxins, the peptide toxins isolated from sea gastropods of the genus Conus. It covers publications from conotoxin discovery in 1970th up to contemporary research and considers classification of conotoxins, their structural diversity and different ways of their action on molecular targets, particularly, ion channels. Special attention is paid to the applied aspect of conotoxin research especially to perspectives of the development of conotoxin based drugs. The first example of such conotoxin based drug is ziconotide an analgesic of a new generation.

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Authors and Affiliations

  1. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia

    A. E. Fedosov

  2. Department of Biology, University of Utah, 257 South 1400 East, rm. 201, Salt Lake City, UT, 84112-0840, USA

    A. E. Fedosov & B. M. Olivera

  3. Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119121, Russia

    S. A. Moshkovskii & K. G. Kuznetsova

  4. Biological Faculty, Lomonosov Moscow State University, Leninskie Gory 1, bld. 12, Moscow, 119991, Russia

    K. G. Kuznetsova

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  1. A. E. Fedosov
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  2. S. A. Moshkovskii
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  3. K. G. Kuznetsova
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  4. B. M. Olivera
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Original Russian Text © A.E. Fedosov, S.A. Moshkovskii, K.G. Kuznetsova, B.M. Olivera, 2012, published in Biomeditsinskaya Khimiya.

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Fedosov, A.E., Moshkovskii, S.A., Kuznetsova, K.G. et al. Conotoxins: From the biodiversity of gastropods to new drugs. Biochem. Moscow Suppl. Ser. B 6, 107–122 (2012). https://doi.org/10.1134/S1990750812020059

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