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ACE inhibitors as activators of kinin receptors

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Abstract

Angiotensin converting enzyme (ACE) inhibitors are widely used for treatment of cardiovascular diseases. Studies of interaction of ACE inhibitors with bradykinin receptors have shown that ACE inhibitors potentiate bradykinin effects not only by blocking its inactivation but also by activation of its receptors. The mechanism of activation and also structural features of the kinin B2R and B1R receptors by ACE inhibitors have been characterized and amino acid residues involved into kinin receptor coupling to G proteins have been identified. Kinins and their receptors are involved into positive therapeutic effect of ACE inhibitors.

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  1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119121, Russia

    E. V. Kugaevskaya & Yu. E. Elisseeva

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Original Russian Text © E.V. Kugaevskaya, Yu.E. Elisseeva, 2010, published in Biomeditsinskaya Khimiya.

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Kugaevskaya, E.V., Elisseeva, Y.E. ACE inhibitors as activators of kinin receptors. Biochem. Moscow Suppl. Ser. B 4, 309–320 (2010). https://doi.org/10.1134/S1990750810040013

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