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Alkyl-type glycerolipids as modulators of tumor cells destruction

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Abstract

The review summarizes current information on the biological activity and search of the antineoplastic mechanism of action among alkyl glycerolipids. Special attention is paid to following problems considered in experimental papers published during the last decade: selective ability phosphorus alkyl glycerolipids towards tumor cells using edelfosine and its analogues. The review contains modern information available in the literature, on a possible mechanism cytotoxic effect of such compounds.

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Abbreviations

(DR):

death receptors such as CD95, which directly induce activation of caspase-8 inside the DISC complex, which consists of a receptor cluster and the molecular adapter FADD

(Edelfosine):

1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe)

(FADD):

Fas-associated death domain protein of the death-inducing signaling complex (DISC)

PBL:

peripheral blood leukocytes; (TNF) tumor necrosis factor.

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Authors and Affiliations

  1. Lomonosov Moscow State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia

    S. G. Romanova, V. G. Romanov & G. A. Serebrennikova

  2. Blokhin Oncological Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 24, Moscow, 115478, Russia

    A. A. Shtil

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  1. S. G. Romanova
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  2. V. G. Romanov
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  3. G. A. Serebrennikova
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  4. A. A. Shtil
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Correspondence to S. G. Romanova.

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Original Russian Text © S.G. Romanova, V.G. Romanov, G.A. Serebrennikova, A.A. Shtil, 2010, published in Biomeditsinskaya Khimiya.

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Romanova, S.G., Romanov, V.G., Serebrennikova, G.A. et al. Alkyl-type glycerolipids as modulators of tumor cells destruction. Biochem. Moscow Suppl. Ser. B 4, 161–170 (2010). https://doi.org/10.1134/S199075081002006X

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  • DOI: https://doi.org/10.1134/S199075081002006X

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