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The Effect of Perfluorocarbon Nanoparticles on Blood As a Cellular System

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Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Aims and scope

Abstract—

The effect of perfluorocarbon (PFC) nanoparticles on the functioning of blood cells is considered. Evidence is presented indicating that emulsified PFC nanoparticles in small volumes affect gas transport function of blood, increasing the rate of oxygen diffusion from erythrocytes to tissues. It was found that PFC nanoparticles also affect the state of blood cells (erythrocytes, leukocytes, and platelets) in a dose-dependent manner. It was assumed that depending on the emulsion dose, that is, the density of nanoparticles in the surrounding space of cells, the reaction of receptor apparatus can cause activation or deterioration of their functioning.

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REFERENCES

  1. Riess J.G., Flaim S.F., Klein D.H., Weers J.G. 1995. The relative physicochemical and biological atrtributes of perflubron emulsions. In: Perfluorocarbon compounds in biology and medicine. Ed. Ivanitsky G.R., Moroz V.V. Pushchino, p. 73–90.

  2. Coch C.S., Cushing M.M. 2009. Oxygen therapeutics: Perfluorocarbons and blood substitute safety. Crit. Care Clin. 25, 399–414. https://doi.org/10.1016/j.ccc.2008.12.007

  3. Henkel-Hanke T., Oleck M. 2007. Artificial oxygen carriers: A current review. Am. As. Nurse Anest. J. 75 (3), 205–211.

    Google Scholar 

  4. Mayevsky E.I., Aksenova O.G., Bogdanova L.A., Ivanitsky G.R. 2004. Analysis of side clinical effects identified during phase I–II clinical trials of Perfluorane. Vestnik sluzhbi krovi Rossii (Rus.). 4, 23–29.

  5. Vercellotti G.M., Hammerschmidt D.E., Craddock P.R., Jacob H.S. 1982. Activation of plasma complement by perfluorocarbon artificial blood: Probable mechanism of adverse pulmonary reactions in treated patients and rationale corticosteroids prophylaxis. Blood. 59, 1299–1304.

    Article  CAS  PubMed  Google Scholar 

  6. Flaim S.F. 1994. Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes (review). Atif. Cells, Blood Substit. Immobil. Biotechnol. 22, 1043–1054.

    Article  CAS  Google Scholar 

  7. Lozhkina A.N. 1987. The participation of the complement system in the regulation of the homeostasis system. Uspekhi sovremennoy biologii (Rus.). 104 (4). 36–54.

  8. Lysenok P.N. 2005. Biomaterial science: Contribution to the progress of modern medical technologies. Kletochnaya transplantologija i kletochnaja inzhenerija (Rus.). 2, 56–61.

  9. Kuznetsova I.N., Bezrukova A.G., Lopatin V.N., Parshin A.V. 1988. Determination of the refractive index and the thickness of the envelope of dispersed blood substitute particles based on perfluoro compounds. Biofizika (Rus.). 33 (1), 126–129.

    CAS  Google Scholar 

  10. Naito R., Yokoyama K. 1978. Perfluorochemical blood substitutes. Technical information series. No. 5. Chome, Joto-ku, Osaka, Japan: The Green Cross Corporation, p. 1–47.

  11. Nakagaki M. 1991. Fizicheskaya khimiya membran (Physical chemistry of membranes). M.: Mir.

  12. Kuznetsova I.N. 1999. Funkcionalnaya aktivnost’ I stabilnost emulsify perftorugleerodov. (Functional activity and stability of perfluorocarbon emulsions). Doct. Sci. (Boil.) Dissertation Russian Inst. Hematol. Transfusiol, St. Petersburg, 1999.

  13. Klenin V.I., Shchegolev S.Yu., Lavrushin V.I. 1977. Harakteristicheskie funktsii tsvetorasseyaniya dispersnykh system (Characteristic light scattering functions of dispersed systems). Saratov: Publishing House of the Saratov University.

  14. Kuznetsova I.N., Kruglyak Z.A. 1987. Determination of particle sizes of aqueous dispersed preparations by spectroturbidimetry. Khimiko-farmatsevticheskiy zhurnal (Rus.). 31 (12), 1492–1503.

  15. Kuznetsova I.N., Gokhman N.S., Lavrova Yu.V. 1993. Interaction of perfluorocarbon emulsion particles with blood serum. Zhurnal fizicheskoy khimii (Rus.). 67 (9), 1884–1888.

  16. Kuznetsova I.N., Yurchenko V.S. 2006. Stability of the structure of emulsions based on perfluorocarbons and phospholipids during storage. Khimiko-farmatsevticheskiy zhurnal (Rus.). 40 (12), 35–38.

  17. Kuznetsova I.N. 2015. About mechanism of gas transport function and side reactions of perfluorocacbon nano-dispersions. Current Bionanotechnology. 1, 51–59.

    Article  Google Scholar 

  18. Musil Ya., Novakova O., Kunts K. 1984. Sovremennaya biokhimiya v skhemakh (Modern biochemistry in schemes). M.: Mir.

  19. Miuro K., Watanabe H., Kato H. 1983. Study of the behavior of uptake and release of oxygen into perfluorocarbon-water emulsion. Bull. Chem. Soc. Japan. 56 (2), 386–388.

    Article  Google Scholar 

  20. Zaritsky A.R., Kuznetsova I.N., Perevedentseva E.V., Fok M.V. 1993. The effect of perfluorocarbon emulsions on the rate of oxygenation and deoxygenation of blood. Zhurnal fizicheskoy khimii. (Rus.). 67 (3), 591–594.

  21. Chizhevsky A.L. 1959. Strukturniy analiz dvizhushcheisia krovi (Structural analysis of moving blood). M.: USSR Academy of Sciences.

  22. Kuznetsova I.N. 2001. The effect of perfluorocarbon emulsions on the rheological parameters of blood. Biofizika (Rus.). 46 (4), 761–765.

    CAS  Google Scholar 

  23. Kuznetsova I.N. 2001. On the effect of perfluorocarbon emulsion on the body. In: Perfluorocarbon compounds in biology and medicine. Ed. Ivanitsky G.R., Moroz V.V. Pushchino, pp. 70–76.

  24. Kuznetsova I.N., Volkova S.D., Rybakova L.P., Yurchenko V.S., Kochetkova G.A. 2009. Perfluorocarbon emulsions affect the morphofunctional state of blood cells, erythrocytes and leukocytes in vitro. Vestnik sluzhbi krovi Rossii (Rus.). 2, 23–26.

  25. Volkova S.D., Kuznetsova I.N., Bessemeltsev S.S. 2014. The effect of perfluorocarbon emulsions on the functional state of blood cells. Medline.ru (Rus.). 15, article 12, 117–133.

  26. Tarkovskaya L.R., Kuznetsova I.N., Morozova T.V., Papayan L.P. 2009. Dose-dependent effect of perfluorocarbon emulsions on induced platelet aggregation. Vestnik sluzhbi krovi Rossii (Rus.). 3, 25–30.

  27. Filev L.V., Zakharov I.I., Selivanova G.V. 1989 Cytospectrophotometric study of hemoglobin in human erythrocytes. Tsitologiya (Rus.). 31 (3), 336–343.

    CAS  Google Scholar 

  28. Nagoev B.S., Shubich M.G. 1981. The significance of the nitrosine tetrazolium recovery test for studying the functional activity of leukocytes. Laboratornoye delo (Rus.). 4, 195–198.

  29. Egorova A.P., Lebedinsky V.A. 1949. The significance of the phagocytic reaction in determining the invasiveness of hemolytic streptococcus. Zhurnal mikrobiologii, epidemiologii i immunobiologii (Rus.). 5, 8–9.

  30. Savchenko Z.I., Erasova V.I. 1981. Functional state of peripheral blood neutrophils in patients with bronchial asthma. Laboratornoye delo (Rus.). 11, 661–664.

  31. The R Project for Statistical Computing. https://www. r‑project.org.

  32. Vavilova T.V., Golovina O.G., Zainulina M.S., Ivanov I.V., Mindukshev I.V., Papayan L.P., Petrishchev N.N., Shitikova A.S., Emmanuel V.L. 1999. Gomeostaz. Fiziologicheskie mekhanismi, principi diagnostiki osnovnih form gemorragicheskih zabolevaniy (Hemostasis. Physiological mechanisms, principles of diagnosis of the main forms of hemorrhagic diseases). Ed. Petrishchev N.N., Papayan L.P. St. Petersburg: Publishing House of SPBSMU.

  33. Kuznetsova I.N., Yurchenko V.S., Kochetkova G.A. 2012. Stable nanodispersions based on perfluorocarbons and phospholipids. Khimiko-farmacefticheskiy zhurnal (Rus.). 46 (2), 52–56.https://doi.org/10.1007/s11094-0120-0745-9

  34. Kuznetsova I.N., Staritsyna N.N., Lyanguzov A.Yu. 2020. Biophysical properties and stability of nanoparticles based on perfluorocarbons and phospholipids. Zhurnal fizicheskoy khimii. (Rus.). 94 (3), 443. https://doi.org/10.31857/S0044453720020211

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ACKNOWLEDGMENTS

The authors of this analytical review are grateful to all the authors of previously published studies, personally Volkova S.D. and Tarkovskaya L.R. Despite the fact that the quoted results were conducted almost 10 years ago, their additional analysis showed the topicality of the tasks.

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Authors and Affiliations

  1. Russian Research Institute of Hematology and Transfusiology, 191024, St. Petersburg, Russia

    I. N. Kuznetsova

  2. St.-Petersburg State University, 199034, St. Petersburg, Russia

    A. Yu. Lyanguzov

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  1. I. N. Kuznetsova
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  2. A. Yu. Lyanguzov
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Correspondence to I. N. Kuznetsova.

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Translated by E. Puchkov

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Kuznetsova, I.N., Lyanguzov, A.Y. The Effect of Perfluorocarbon Nanoparticles on Blood As a Cellular System. Biochem. Moscow Suppl. Ser. A 17, 20–27 (2023). https://doi.org/10.1134/S1990747823010051

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