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Molecular dynamics investigation of nitric oxide (II) interaction with a model biological membrane

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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology Aims and scope

Abstract

Nitric oxide (II) diffusion through a model two-component (phosphatidylcholine and phosphatidylethanolamine molecules) biological membrane is investigated using the molecular dynamics method. It is shown that NO molecules are rotating in the process of diffusion into the phospholipid bilayer. The calculated diffusion coefficient D[NO] = 0.35 (±0.23) × 10−5 (cm2/s) is in a good agreement with literature data. This testifies that free diffusion of NO molecules may be a plausible mechanism of the NO permeation through the membranes.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskay nab., 7/9, St. Petersburg, 199034, Russia

    A. A. Mamonov & V. E. Stefanov

  2. Pavlov Institute of Physiology of the Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg, 199034, Russia

    B. F. Shchegolev

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  1. A. A. Mamonov
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  2. V. E. Stefanov
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  3. B. F. Shchegolev
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Correspondence to V. E. Stefanov.

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Original Russian Text © A.A. Mamonov, V.E. Stefanov, B.F. Shchegolev, 2009, published in Biologicheskie Membrany, 2009, Vol. 26, No. 3, pp. 224–233.

The article is translated by the authors.

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Mamonov, A.A., Stefanov, V.E. & Shchegolev, B.F. Molecular dynamics investigation of nitric oxide (II) interaction with a model biological membrane. Biochem. Moscow Suppl. Ser. A 3, 231–238 (2009). https://doi.org/10.1134/S1990747809020172

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  • DOI: https://doi.org/10.1134/S1990747809020172

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