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Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly

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Abstract

Although systemic inflammation has been linked to acromegaly, little is known about the abnormalities in cytokine networks during the disease. The aim of this study was to evaluate the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and activin-A in acromegaly, and to investigate the relationship between TNF-alpha, IL-6, activin-A and comorbidities of acromegaly. A total of 56 subjects were recruited to the study. Serum samples were collected from 31 acromegaly patients and 25 healthy control subjects. Serum activin-A, IL-6 and TNF-alpha were determined using the enzyme-linked immunosorbent assay. Circulating levels of activin-A, TNF-alpha, and IL-6 were higher in patients than in the control group. Receiver operating characteristic analysis for activin-A for the differentiation of acromegaly patients from healthy control subjects showed an area under the curve of 0.90. Higher activin-A levels were determined in patients with residual pituitary tumor. These findings provide evidence for the role of activin-A, TNF-alpha and IL-6 in acromegaly. Serum activin-A levels could be used as a novel biomarker to diagnose acromegaly. These findings confirm previous studies that inflammation might be involved in the pathogenesis of acromegaly. Finally, treatment strategies targeting the regulation of inflammation cannot be sufficient alone in reducing comorbidities.

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Authors and Affiliations

  1. Department of Biochemistry, Sivas Numune Hospital, Sivas, Turkey

    Kübra Doğan

  2. Department of Biochemistry, School of Medicine, University of Sivas Cumhuriyet, Sivas, Turkey

    Şeyma Nur Yıldız & Serkan Bolat

  3. Department of Endocrinology and Metabolic Disorders, School of Medicine, University of Sivas Cumhuriyet, Sivas, Turkey

    Barış Sarıakçalı & Gülhan Duman

Authors
  1. Kübra Doğan
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  2. Şeyma Nur Yıldız
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  3. Barış Sarıakçalı
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  4. Gülhan Duman
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  5. Serkan Bolat
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Correspondence to Kübra Doğan.

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Conflict of interest. The authors declared no conflict of interest.

Ethical approval. The procedures were approved by the Ethics Committee of Cumhuriyet University following the ethical standards established by the institution an all procedures were applied in accordance with the Helsinki Declaration (Decision number: 2019-04-04).

Informed consent. Informed consent was obtained from all individual participants included in the study.

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Doğan, K., Yıldız, Ş.N., Sarıakçalı, B. et al. Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly. Neurochem. J. 15, 325–330 (2021). https://doi.org/10.1134/S181971242103003X

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  • DOI: https://doi.org/10.1134/S181971242103003X

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