Skip to main content
SpringerLink
Log in

The effect of the glycyl-proline dipeptide on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia

  • Experimental Articles
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract

We studied the effects of the glycyl-proline dipeptide (Gly-Pro) at a dose of 3 mg/kg on the contents of neuroactive amino acids, including aspartate, glycine, alanine, taurine, GABA, and glutamate, the activity of the enzymes of the GABA shunt, such as GABA-transaminase, succinic semialdehyde dehydrogenase, and glutamate decarboxylase, and enzymes of glutamate metabolism, such as glutamate dehydrogenase and alanine and aspartate transaminases in the neocortex of rats subjected to 6-h brain ischemia. We used three means of dipeptide administration, including intraperitoneal, subconjunctival, and intranasal. We found that the protective anti-ischemic effect of Gly-Pro was mostly expressed after intranasal administration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ashmarin, I.P. and Koroleva, S.V., Uspekhi Funktsional’noi Neirokhimii, 2003, pp. 85–94.

    Google Scholar 

  2. Ashmarin, I.P. and Koroleva, S.V., Vesti Ros. Akad. Nauk, 2002, no. 6, pp. 40–48.

    Google Scholar 

  3. Gomazkov, O.A., Biomeditsinskaya Khimiya, 2004, vol. 50, no. 4, pp. 321–343.

    Google Scholar 

  4. Levi-Montalcini, R., EMBO J., 1987, no. 6, pp. 1145–1154.

    Google Scholar 

  5. Strand, F.L., Progr. Drug Res., 2003, vol. 61, no. 1, pp. 1–37.

    CAS  Google Scholar 

  6. Mendzheritskii, A.M., Lysenko, A.V., Fateeva, L.V., and Mendzheritskaya, L.G., Uspekhi Funktsional’noi Neirokhimii, 2003, pp. 115–120.

    Google Scholar 

  7. Khavinson, V.Kh., Kvetnoi, I.M., and Ashmarin, I.N., Usp. Sovrem. Biol., 2002, vol. 122, no. 2, pp. 190–203.

    CAS  Google Scholar 

  8. Koroleva, S.V. and Ashmarin, I.P., J. Theor. Biol., 2002, vol. 216, no. 3, pp. 257–271.

    Article  PubMed  CAS  Google Scholar 

  9. Guan, J., Waldvogel, H.J., Faull, R.L., Gluckman, P.D., and Williams, C.E., Neuroscience, 1999, vol. 89, no. 3, pp. 649–659.

    Article  PubMed  CAS  Google Scholar 

  10. Yakovleva, E.V., Kuzenkov, V.S., and Fedorov, V.N., Byull. Eksperim. Biol. Med., 1999, vol. 128, no. 8, pp. 172–174.

    Google Scholar 

  11. Gusev, E., Skvortsova, V., Dambinova, S., Raevskiy, E., Alekseeva, A., Bashkatova, V., Kovalenko, A., Kudrin, V., and Yakovleva, E., Cerebrovasc. Dis., 2000, vol. 10, pp. 49–60.

    Article  PubMed  CAS  Google Scholar 

  12. Us, K.S., Klodt, P.M., and Kudrin, V.S., Neirokhimiya, 2006, vol. 23, no. 2, pp. 122–126.

    Google Scholar 

  13. Shevchenko, V.P., Myasoedov, N.F., Bezuglov, V.V., Bobrov, M.Yu., Shevchenko, K.V., and V’yunova, T.V., Neirokhimiya, 2006, vol. 23, no. 1, pp. 57–62.

    Google Scholar 

  14. Bashkatova, V.G. and Koshelev, V.B., Uspekhi Funktsional’noi Neirokhimii, 2003, pp. 108–114.

    Google Scholar 

  15. Telushkin, P.K., Vopr. Med. Khim., 1998, vol. 44, no. 6, pp. 520–526.

    PubMed  CAS  Google Scholar 

  16. Ginsberg, M.D., Cerebrovasc. Dis., 1997, vol. 7,suppl. 2, pp. 7–12.

    Article  Google Scholar 

  17. Skvortsova, V.I., Vestn. Ros. Akad. Med. Nauk, 2003, no. 11, pp. 74–80.

    Google Scholar 

  18. Grieb, P., Mozg a Niedokrwienie (Brain and Ischemia), eds., Strosznajder, J. and Czernicki, Z., Krakow, 2005.

  19. Kitagawa, R.M., Matsumoto, T., and Oda, M., Neuroscience, 1990, vol. 35, pp. 551–558.

    Article  PubMed  CAS  Google Scholar 

  20. Dubinina, E.E., Vopr. Med. Khim., 2001, vol. 47, no. 6, pp. 561–581.

    PubMed  CAS  Google Scholar 

  21. Raevskii, K.S., Romanova, G.A., and Kudrin, V.S., Byull. Eksperim. Biol. Med., 1997, vol. 123, no. 4, pp. 370–373.

    Google Scholar 

  22. Biokhimiya mozga: uchebnoe posobie (Biochemistry of the Brain: A Handbook), eds., Ashmarin, I.P., Stukalov, P.V., and Eshchenko, N.D., St. Petersburg, 1999.

    Google Scholar 

  23. Hossmann, A., Cardiovasc. Res., 1998, vol. 39, pp. 106–120.

    Article  PubMed  CAS  Google Scholar 

  24. Lobanova, N.N., Byull. Eksperim. Biol. Med., 2008, vol. 146, no. 12, pp. 627–630.

    Google Scholar 

  25. Bashun, N.Z., Raduta, E.F., Balash, Zh.I., Kirvel’, P.Ch., Sushko, L.I., Kanunnikova, N.P., and Moiseenok, A.G., Neirokhimiya, 2007, vol. 24, no. 1, pp. 60–64.

    CAS  Google Scholar 

  26. Graham, L.T. and Aprison, M.H., J. Neurochem., 1969, vol. 16, pp. 559–566.

    Article  PubMed  CAS  Google Scholar 

  27. De Boer, Th. and Bruinvels, J., J. Neurochem., 1977, vol. 28, pp. 471–478.

    Article  PubMed  Google Scholar 

  28. Eshchenko, N.D., Vol’skii, G.G., and Prokhorova, M.I., Metody biokhimicheskikh issledovanii (Methods of Biochemical Studies), Leningrad: Izd-vo LGU, 1982, pp. 210–212.

    Google Scholar 

  29. Eshchenko, N.D., Metody biokhimicheskikh issledovanii (Methods of Biochemical Studies), Leningrad: Izd-vo LGU, 1982, pp. 202–206.

    Google Scholar 

  30. Karaedova, L.M. and Ostrovskii, Yu.M., Klin. Lab. Diagnostika, 1993, no. 2, pp. 30–35.

    Google Scholar 

  31. Cherkesova, T.U. and Emirbekov, E.Z., Byull. Eksperim. Biol. Med., 1982, no. 9, pp. 33–34.

    Google Scholar 

  32. Doroshenko, E.M., Respubl. Nauch. Konf. s Mezhdunar. Uch. “Analitika RB-2010”: Sb. Tez. Dokl., 2010, p. 126.

    Google Scholar 

  33. Hartree, E.F., Anal. Biochem., 1972, vol. 48, pp. 422–427.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Grodno State University, Grodno, Belarus

    N. Z. Bashun, E. M. Doroshenko, E. F. Raduta, Zh. I. Balash & N. P. Kanunnikova

  2. Institute of Bioorganic Chemistry, National Academy of Sciences, Minsk, Belarus

    V. P. Golubovich

  3. Scientific and Production Center Institute of Pharmacology and Biochemistry, National Academy of Sciences, Grodno, Belarus

    A. G. Moiseenok

  4. per. Dovatora, 3/1, Grodno, 230012, Belarus

    N. Z. Bashun

Authors
  1. N. Z. Bashun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. M. Doroshenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. F. Raduta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zh. I. Balash
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. P. Kanunnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. P. Golubovich
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. G. Moiseenok
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. Z. Bashun.

Additional information

Original Russian Text © N.Z. Bashun, E.M. Doroshenko, E.F. Raduta, Zh.I. Balash, N.P. Kanunnikova, V.P. Golubovich, A.G. Moiseenok, 2013, published in Neirokhimiya, 2013, Vol. 30, No. 1, pp. 46–51.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bashun, N.Z., Doroshenko, E.M., Raduta, E.F. et al. The effect of the glycyl-proline dipeptide on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia. Neurochem. J. 7, 39–44 (2013). https://doi.org/10.1134/S1819712412040046

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712412040046

Keywords

Search

Navigation