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Neurochemical Journal

, Volume 7, Issue 1, pp 39–44 | Cite as

The effect of the glycyl-proline dipeptide on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia

  • N. Z. BashunEmail author
  • E. M. Doroshenko
  • E. F. Raduta
  • Zh. I. Balash
  • N. P. Kanunnikova
  • V. P. Golubovich
  • A. G. Moiseenok
Experimental Articles
  • 91 Downloads

Abstract

We studied the effects of the glycyl-proline dipeptide (Gly-Pro) at a dose of 3 mg/kg on the contents of neuroactive amino acids, including aspartate, glycine, alanine, taurine, GABA, and glutamate, the activity of the enzymes of the GABA shunt, such as GABA-transaminase, succinic semialdehyde dehydrogenase, and glutamate decarboxylase, and enzymes of glutamate metabolism, such as glutamate dehydrogenase and alanine and aspartate transaminases in the neocortex of rats subjected to 6-h brain ischemia. We used three means of dipeptide administration, including intraperitoneal, subconjunctival, and intranasal. We found that the protective anti-ischemic effect of Gly-Pro was mostly expressed after intranasal administration.

Keywords

neuroactive amino acids brain ischemia glycyl-proline dipeptide 

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • N. Z. Bashun
    • 1
    • 4
    Email author
  • E. M. Doroshenko
    • 1
  • E. F. Raduta
    • 1
  • Zh. I. Balash
    • 1
  • N. P. Kanunnikova
    • 1
  • V. P. Golubovich
    • 2
  • A. G. Moiseenok
    • 3
  1. 1.Grodno State UniversityGrodnoBelarus
  2. 2.Institute of Bioorganic ChemistryNational Academy of SciencesMinskBelarus
  3. 3.Scientific and Production Center Institute of Pharmacology and BiochemistryNational Academy of SciencesGrodnoBelarus
  4. 4.GrodnoBelarus

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