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Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid

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Abstract

We developed a new experimental model of oxidative stress in rats, which combines the effects of 3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protective effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant carnosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas carnosine is also effective under conditions of elevated homocysteine level.

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Authors and Affiliations

  1. Laboratory of Biochemistry of Amines and Cyclic Nucleotides, Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia

    I. S. Dobrotvorskaya & T. T. Berezov

  2. Laboratory of Clinical and Experimental Neurochemistry, Research Centre of Neurology, Russian Academy of Medical Sciences, Moscow, Russia

    I. S. Dobrotvorskaya & T. N. Fedorova

  3. Department of Medical Biochemistry, Jesseinus Faculty of Medicine, Comenius University, Martin, Slovak Republic

    D. Dobrota

Authors
  1. I. S. Dobrotvorskaya
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  2. T. N. Fedorova
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  3. D. Dobrota
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  4. T. T. Berezov
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Correspondence to I. S. Dobrotvorskaya.

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Original Russian Text © I.S. Dobrotvorskaya, T.N. Fedorova, D. Dobrota, T.T. Berezov, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 1, pp. 49–54.

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Dobrotvorskaya, I.S., Fedorova, T.N., Dobrota, D. et al. Characteristics of oxidative stress in experimental rat brain ischemia aggravated by homocysteic acid. Neurochem. J. 5, 42–46 (2011). https://doi.org/10.1134/S1819712410041014

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  • DOI: https://doi.org/10.1134/S1819712410041014

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