Abstract
The dynamics of the pulse wave (PW) associated with the PW transit time variability (PWTTV) determines the peripheral pulse rate variability, which is used as a surrogate for heart rate variability (HRV). The aim of the work is to analyze the frequency-dependent dynamics of PWTTV and to identify the possible frequency-phase modulation of PW velocity oscillations on the transit from the heart to the soft tissues of the distal parts of the upper extremities. RR-interval recordings and synchronous records of photoplethysmograms of 12 conditionally healthy subjects from the PhysioNet open database were used in this work. Using the Hilbert–Huang transform 3 spectral components of PWTTV and HRV were identified. It was shown that the amplitudes of PWTTV oscillations were many times (up to 8.4 times) smaller than the amplitudes of HRV, and the peaks of PWTTV spectral components were shifted towards higher frequencies than those of HRV. Functional relations between PWTTV and HRV, which can determine the phase modulation of periodic changes in the PW propagation velocity, were revealed.
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ACKNOWLEDGMENTS
The authors thank Academician V.N. Shabalin for constructive discussion of manuscript versions.
Funding
The work was performed under the state assignments of the Institute of Cell Biophysics of the Russian Academy of Sciences.
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ETHICS APPROVAL AND CONSENT TO PARTICIPATE
This work does not contain any studies involving human and animal subjects. Data analysis was performed from the open-access database Pulse Transit Time PPG Dataset (version 1.1.0) [9]. According to the Pulse Transit Time PPG Dataset data, all studies were conducted in accordance with the principles of biomedical ethics set out in the 1964 Declaration of Helsinki and its subsequent amendments, and all participants provided written informed consent.
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Translated by M. Batrukova
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Grinevich, A.A., Chemeris, N.K. Frequency-Dependent Variability of Pulse Wave Transit Time: Pilot Study. Dokl Biochem Biophys 516, 107–110 (2024). https://doi.org/10.1134/S1607672924700807
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DOI: https://doi.org/10.1134/S1607672924700807