Skip to main content
SpringerLink
Log in

The Use of the Antigenic Protein HPV6 L1 to Induce the Synthesis of Interferon, CD4 and CD8 T Lymphocytes, and Granzyme B in Blood and Splenocytes of Mice in Order to Develop a Broad Vaccine against Anogenital Papillomatoses

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

The antigenic protein HPV6 L1 was synthesized in the plant expression system based on transgenic tomato fruit during the development of an oral vaccine against anogenital papillomaviruses. In experiments on mice immunization, new data on the induction of the T-cell immune response were obtained, which were recorded by the results of activation of the synthesis of interferon, CD4 and CD8 T lymphocytes, and granzyme B secreted by them in peripheral mononuclear blood cells and splenocytes of mice that were previously vaccinated with the vaccine material of tomato fruit with the HPV6 L1 gene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Bruni, L., Albero, G., Serrano, B., et al., ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and related Diseases in the World, Summary Report WHO June 17, 2019.

  2. Bonagura, V.R., Hatam, L.J., Rosenthal, D.W., et al., APMIS, 2010, vol. 118, pp. 455–470.

    Article  CAS  Google Scholar 

  3. Rekoslavskaya, N.I., Salyaev, R.K., and Stolbikov, A.S., Dokl. Biochem. Biophys., 2021, vol. 498, pp. 193–199.

    Article  CAS  Google Scholar 

  4. Salyaev, R.K., Rekoslavskaya, N.I., and Stolbikov, A.S., Ross. Nanotekhnol., 2020, vol. 15, pp. 132–138.

    Google Scholar 

  5. Salyaev, R.K., Rekoslavskaya, N.I., and Stolbikov, A.S., Dokl. Biochem. Biophys., 2019, vol. 488, pp. 316–319.

    Article  CAS  Google Scholar 

  6. Poteryaev, D.A., Khamitov, R.A., Efimov, G.A., and Shuster, A.M., Bioprep. Profilakt. Diagn. Lechen., 2020, vol. 20, pp. 144–158.

    Google Scholar 

  7. Shin, T.H., Pankhong, P., Yan, J., Khan, A.S., et al., Hum. Vaccines Immunother., 2021, vol. 8, pp. 470–478.

    Article  Google Scholar 

  8. Belone, S., El-Sahwi, K., Cocco, E., Casagrande, F., et al., J. Virol., 2009, vol. 83, pp. 6779–6789.

    Article  Google Scholar 

  9. Paz De la Rosa, G., Monroy-Garcia, A., de Lourdes Mora-Garcia, M., et al., Virol. J., 2009, vol. 6, pp. 1–11.

    Article  Google Scholar 

  10. Dorta-Estremera, S., Chin, R.L., Sierra, G., et al., Cancer Res., 2018, vol. 78, pp. 5327–5339.

    Article  CAS  Google Scholar 

  11. Shubnikova, E.V., Bukatina, T.M., Vel’ts, N.Yu., et al., Bezop. Risk Farmakoter., 2020, vol. 8, pp. 9–22.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia

    R. K. Salyaev & N. I. Rekoslavskaya

Authors
  1. R. K. Salyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. I. Rekoslavskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. I. Rekoslavskaya.

Ethics declarations

Conflict of interest. The authors declare that they have no conflict of interests.

Statement on the welfare of animals. Work with mice was approved at a meeting of the Bioethical Council of the Siberian Branch of the Russian Academy of Sciences (meeting minutes no. 9 of October 30, 2019). The mice were housed in compliance with the standard conditions described in GOST 33215-2014 and GOST 33216-2014.

Additional information

Translated by M. Batrukova

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salyaev, R.K., Rekoslavskaya, N.I. The Use of the Antigenic Protein HPV6 L1 to Induce the Synthesis of Interferon, CD4 and CD8 T Lymphocytes, and Granzyme B in Blood and Splenocytes of Mice in Order to Develop a Broad Vaccine against Anogenital Papillomatoses. Dokl Biochem Biophys 500, 335–340 (2021). https://doi.org/10.1134/S160767292105015X

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S160767292105015X

Keywords:

Search

Navigation