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Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series

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Abstract

Schiff bases of the tetrahydropyran series have been synthesized by the condensation of 2-(tetra­hydropyran-4-yl)ethanamines and tetrahydropyran-4-amine with 4-chloro, 4-fluoro-, and 4-(dimethylamino)­benzaldehydes and thiophene-2-carbaldehyde. The synthesized compounds showed lower anti-inflammatory, analgesic, and antipyretic activities than those of diclofenac and indomethacin used as reference drugs.

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Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    A. U. Isakhanyan, N. Z. Hakobyan, R. E. Muradyan, H. E. Tumajyan, H. A. Panosyan & A. A. Harutyunyan

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  1. A. U. Isakhanyan
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  2. N. Z. Hakobyan
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  3. R. E. Muradyan
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  4. H. E. Tumajyan
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  5. H. A. Panosyan
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  6. A. A. Harutyunyan
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Corresponding author

Correspondence to A. U. Isakhanyan.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

Bio­logical experiments were carried out in full com­pliance with the European Convention and Directives of the European Parliament for the protection of vertebrate animals used for experimental and other scientific purposes [5].

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The authors declare that they have no conflicts of interest.

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Isakhanyan, A.U., Hakobyan, N.Z., Muradyan, R.E. et al. Synthesis and Anti-inflammatory, Analgesic, and Antipyretic Activities of Azomethine Derivatives of the Tetrahydropyran Series. Russ J Org Chem 60, 539–542 (2024). https://doi.org/10.1134/S1070428024030230

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  • DOI: https://doi.org/10.1134/S1070428024030230

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