Abstract
Previously unknown methyl N-(3-substituted thiophen-2-yl)carbamimidothioates were synthesized in one preparative step from hetero-substituted allenes (methoxy-, 1-ethoxyethoxy-, and 1H-pyrrol-1-ylallenes) and aliphatic, cycloaliphatic, and aromatic isothiocyanates, and their behavior under electron impact (70 eV) and chemical ionization (reactant gas methane) was studied for the first time. Unstable molecular ion derived from the title compounds under electron impact decomposes mainly via C–N bond cleavage in the carbamimidothioate fragment with charge localization on the imide nitrogen atom. A similar fragmentation pathway is observed in the chemical ionization mass spectra of these compounds. Characteristic but low-intense ion peaks in the electron impact mass spectra of methyl N-(3-methoxythiophen-2-yl)carbamimidothioates become predominating in their chemical ionization mass spectra. The base peak in the chemical ionization mass spectra of methyl N-[3-(1H-pyrrol-1-yl)thiophen-2-yl]carbamimidothioates is that of the [M – SMe]+ ion. The most abundant ion in the chemical ionization mass spectrum of methyl N-[3-(1-ethoxyethoxy)thiophen-2-yl]carbamimidothioate was generated by successive elimination of ethoxyethene and methanethiol molecules from the [M + H]+ ion.
REFERENCES
Klyba, L.V., Nedolya, N.A., Sanzheeva, E.R., and Tarasova, O.A., Russ. J. Org. Chem., 2021, vol. 57, p. 1901. https://doi.org/10.1134/S1070428021120022
Thiophenes, Joule, J.A., Ed. (Topics in Heterocyclic Chemistry series, vol. 39), Heidelberg: Springer, Cham, 2015, p. 1. https://doi.org/10.1007/7081_2014_130
Besson, T. and Thiéry, V., Top. Heterocycl. Chem., 2006, vol. 1, p. 59. https://doi.org/10.1007/7081_008
Mancuso, R. and Gabriele, B., Molecules, 2014, vol. 19, p. 15687. https://doi.org/10.3390/molecules191015687
Mishra, A., Ma, C.-Q., and Bäuerle, P., Chem. Rev., 2009, vol. 109, p. 1141. https://doi.org/10.1021/cr8004229
Klingstedt, T. and Nilsson, K.P.R., Biochem. Soc. Trans., 2012, vol. 40, p. 704. https://doi.org/10.1042/BST20120009
Cheylan, S., Fraleoni-Morgera, A., Puigdollers, J., Voz, C., Setti, L., Alcubilla, R., Badenes, G., Costa-Bizzarri, P., and Lanzi, M., Thin Solid Films, 2006, vol. 497, p. 16. https://doi.org/10.1016/j.tsf.2005.09.177
Ong, B.S., Wu, Y., Li, Y., Liu, P., and Pan, H., Chem. Eur. J., 2008, vol. 14, p. 4766. https://doi.org/10.1002/chem.200701717
Abd-El-Aziz, A.S. and Afifi, T.H., Dyes Pigm., 2006, vol. 70, p. 8. https://doi.org/10.1016/j.dyepig.2005.03.004
Nassar, H.S., Int. J. Text. Sci., 2015, vol. 4, p. 102. https://doi.org/10.5923/j.textile.20150405.02
Wu, L.-H., Wang, Y.-C., and Hsu, C.-S., Liq. Cryst., 2001, vol. 27, p. 1503. https://doi.org/10.1080/026782900750018672
Mishra, R., Jha, K.K., Kumar, S., and Tomer, I., Pharma Chem., 2011, vol. 3, p. 38.
Chaudhary, A., Jha, K.K., and Kumar, S., J. Adv. Sci. Res., 2012, vol. 3, p. 3.
Mabkhot, Y.N., Kheder, N.A., Barakat, A., Choudhary, M.I., Yousuf, S., and Frey, W., RSC Adv., 2016, vol. 6, p. 63724. https://doi.org/10.1039/C6RA09883E
Mishra, R., Sharma, P.K., Verma, P., and Mishra, I., Eur. Chem. Bull., 2016, vol. 5, p. 399. https://doi.org/10.17628/ECB.2016.5.399
Wilson, R., Kumar, P., Parashar, V., Vilchèze, C., Veyron-Churlet, R., Freundlich, J.S., Barnes, S.W., Walker, J.R., Szymonifka, M.J., Marchiano, E., Shenai, S., Colangeli, R., Jacobs, W.R., Jr., Neiditch, M.B., Kremer, L., and Alland, D., Nat. Chem. Biol., 2013, vol. 9, p. 499. https://doi.org/10.1038/nchembio.1277
Lu, X., Wan, B., Franzblau, S.G., and You, Q., Eur. J. Med. Chem., 2011, vol. 46, p. 3551. https://doi.org/10.1016/j.ejmech.2011.05.018
Puterová, Z., Krutošíková, A., and Végh, D., Nova Biotechnol., 2009, vol. 9, p. 167. https://doi.org/10.36547/nbc.1274
Briel, D., Rybak, A., Kronbach, C., and Unverferth, K., Eur. J. Med. Chem., 2010, vol. 45, p. 69. https://doi.org/10.1016/j.ejmech.2009.09.025
Sperry, J.B. and Wright, D.L., Curr. Opin. Drug Discovery Dev., 2005, vol. 8, p. 723.
Corral, C., Lissavetzky, J., Manzanares, I., Darias, V., Exposito-Orta, M.A., Martin Conde, J.A., and Sanchez-Mateo, C., Bioorg. Med. Chem., 1999, vol. 7, p. 1349. https://doi.org/10.1016/S0968-0896(99)00070-X
Yang, S.-M. and Fang, J.-M., Tetrahedron, 2007, vol. 63, p. 1421. https://doi.org/10.1016/j.tet.2006.11.080
Yang, S.-M., Nandy, S.K., Selvakumar, A.R., and Fang, J.-M., Org. Lett., 2000, vol. 2, p. 3719. https://doi.org/10.1021/ol006628w
Schatz, J., Brendgen, T., and Schühle, D., Comprehensive Heterocyclic Chemistry III, Katritzky, A.R., Ramsden, C.A., Scriven, E.F.V., and Taylor, R.J.K., Eds., Amsterdam: Elsevier, 2008, vol. 3, p. 931.
Liu, M., Zeng, M.-T., Xu, W., Chang, C.-Z., Liu, X., Zhu, H., Li, Y.-S., and Dong, Z.B., J. Chem. Res., 2017, vol. 41, p. 165. https://doi.org/10.3184/174751917X14878812592733
Ma, C., Wu, A., Wu, Y., Ren, X., and Cheng, M., Arch. Pharm. (Weinheim, Ger.), 2013, vol. 346, p. 891. https://doi.org/10.1002/ardp.201300276
Sulthana, M.T., Alagarsamy, V., and Chitra, K., Med. Chem. (Sharjah, United Arab Emirates), 2021, vol. 17, p. 352. https://doi.org/10.2174/1573406416666200817153033
Lei, X., Wang, Y., Fan, E., and Sun, Z., Org. Lett., 2019, vol. 21, p. 1484. https://doi.org/10.1021/acs.orglett.9b00275
Padilla-Martinez, I.I., Gonzalez-Encarnacion, J.M., Garcia-Baez, E.V., Cruz, A., and Ramos-Organillo, A.A., Molecules, 2019, vol. 24, article no. 3391. https://doi.org/10.3390/molecules24183391
Sabolova, D., Kristian, P., and Kozurkova, M., J. Appl. Toxicol., 2018, vol. 38, p. 1377. https://doi.org/10.1002/jat.3622
Siddiqui, N., Alam, M.S., Sahu, M., Naim, M.J., Yar, M.S., and Alam, O., Bioorg. Chem., 2017, vol. 71, p. 230. https://doi.org/10.1016/j.bioorg.2017.02.009
Tiratsuyan, S.G., Hovhannisyan, A.A., Karapetyan, A.V., Gomktsyan, T.A., and Yengoyan, A.P., Russ. J. Plant Physiol., 2016, vol. 63, p. 656. https://doi.org/10.1134/S1021443716050125
Bandi, N., Veerachamy, A., and Chitra, K., Drug Res. (Stuttgart, Ger.), 2020, vol. 70, p. 348. https://doi.org/10.1055/a-0991-7617
Boddapati, S.N.M., Kurmarayuni, C.M., Mutchu, B.R., Tamminana, R., and Bollikolla, H.B., Org. Biomol. Chem., 2018, vol. 16, p. 6889. https://doi.org/10.1039/c8ob02018c
Cannito, A., Perrissin, M., Luu Duc, C., Huguet, F., Gaultier, C., and Narcisse, G., Eur. J. Med. Chem., 1990, vol. 25, p. 635. https://doi.org/10.1016/0223-5234(90)90128-P
Katritzky, A.R., Witek, R.M., Rodriguez-Garcia, V., Mohapatra, P.P., Rogers, J.W., Cusido, J., AbdelFattah, A.A.A., and Steel, P.J., J. Org. Chem., 2005, vol. 70, p. 7866. https://doi.org/10.1021/jo050670t
Biswas, A., Mondal, H., and Maji, M.S., J. Heterocycl. Chem., 2020, vol. 57, p. 3818. https://doi.org/10.1002/jhet.4119
Maiti, R., Xu, J., Yan, J.-L., Mondal, B., Yang, X., Chai, H., Hao, L., Jin, Z., and Chi, Y.R., Org. Chem. Front., 2021, vol. 8, p. 743. https://doi.org/10.1039/d0qo01380c
Koronkiewicz, M., Romiszewska, A., Chilmonczyk, Z., and Kazimierczuk, Z., Med. Chem., 2015, vol. 11, p. 364. https://doi.org/10.2174/1573406410666141203124329
Pucko, E., Matyja, E., Koronkiewicz, M., Ostrowski, R.P., and Kazimierczuk, Z., Anticancer Res., 2018, vol. 38, p. 2691. https://doi.org/10.21873/anticanres.12511
Lambert, W.T., Goldsmith, M.E., and Sparks, T.C., Pest Manage. Sci., 2017, vol. 73, p. 743. https://doi.org/10.1002/ps.4353
Narendhar, B., Chitra, K., and Alagarsamy, V., Pharm. Chem. J., 2021, vol. 55, p. 54. https://doi.org/10.1007/s11094-021-02371-7
Narendhar, B., Chitra, K., and Alagarsamy, V., Int. J. Res. Pharm. Sci., 2019, vol. 10, p. 2186. https://doi.org/10.26452/ijrps.v10i3.1414
Uckun, F.M., Tibbles, H.E., Venkatachalam, T.K., and Erbeck, D., Arzneim. Forsch., 2007, vol. 57, p. 483. https://doi.org/10.1055/s-0031-1296636
Klyba, L.V., Nedolya, N.A., Sanzheeva, E.R., and Tarasova, O.A., Russ. J. Org. Chem., 2019, vol. 55, p. 518. https://doi.org/10.1134/S1070428019040171
Nedolya, N.A., Tarasova, O.A., Klyba, L.V., Dmitrieva, G.V., and Trofimov, B.A., Abstracts of Papers, III Mezhdunarodnaya konferentsiya “Khimiya geterotsiklicheskikh soedinenii,” posvyashchennoi 95-letiyu so dnya rozhdeniya professora Alekseya Nikolaevicha Kosta (3rd Int. Conf. “Chemistry of Heterocyclic Compounds” Dedicated to the 95th Anniversary of Prof. A.N. Kost), Moscow, Oct 18–21, 2010, p. 146.
Klyba, L.V., Nedolya, N.A., Shlyakhtina, N.I., and Zhanchipova, E.R., Russ. J. Org. Chem., 2005, vol. 41, p. 1544. https://doi.org/10.1007/s11178-005-0380-y
Klyba, L.V., Nedolya, N.A., Tarasova, O.A., Zhanchipova, E.R., and Volostnykh, O.G., Russ. J. Org. Chem., 2010, vol. 46, p. 218. https://doi.org/10.1134/S107042801002013
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This study was performed using the facilities of the Baikal joint analytical center, Siberian Branch, Russian Academy of Sciences.
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Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 1, pp. 62–72 https://doi.org/10.31857/S0514749223010044.
For communication XXIII, see [1].
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Klyba, L.V., Sanzheeva, E.R., Nedolya, N.A. et al. Mass Spectra of New Heterocycles: XXIV. Electron Impact and Chemical Ionization Study of Methyl N-[3-Alkoxy- and 3-(1H-Pyrrol-1-yl)thiophen-2-yl]carbamimidothioates. Russ J Org Chem 59, 38–46 (2023). https://doi.org/10.1134/S1070428023010037
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DOI: https://doi.org/10.1134/S1070428023010037