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Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles

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Abstract

Novel hydrazones and hexahydro-1H-indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and 1H and 13C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity.

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Funding

The work was financially supported by the Rational Mineral Resource Management Perm Scientific and Educational Center, 2022.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, D. D. Lezhnina & N. V. Nosova

  2. Perm State National Research University, 614990, Perm, Russia

    R.R. Makhmudov & M. V. Dmitriev

  3. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 614045, Perm, Russia

    R.R. Makhmudov

Authors
  1. V. L. Gein
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  2. D. D. Lezhnina
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  3. N. V. Nosova
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  4. R.R. Makhmudov
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  5. M. V. Dmitriev
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Corresponding author

Correspondence to V. L. Gein.

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Additional information

Translated from Zhurnal Organicheskoi Khimii, 2022, Vol. 58, No. 11, pp. 1192–1199 https://doi.org/10.31857/S0514749222110076.

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Gein, V.L., Lezhnina, D.D., Nosova, N.V. et al. Reaction of 6-Oxocyclohexane-1,3-dicarboxamides with Binucleophilic Reagents. Antinociceptive Activity of the Synthesized Hydrazones and 2,3,4,5,6,7-Hexahydro-1H-indazoles. Russ J Org Chem 58, 1610–1616 (2022). https://doi.org/10.1134/S1070428022110070

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