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Unexpected Formation of Indolylmethylene Bis-Meldrum’s Acid Derivatives under Green Conditions

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Abstract

A diversity-oriented, green, and eco-friendly synthesis of 5,5′-(indolylmethylene)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives has been developed by traditional condensation of 3-(1,4-dioxo-1,2,3,4-tetra­hydrophthalazin-2-yl)-3-oxopropanenitrile, 1,5-substituted indole-3-carbaldehydes, and Meldrum’s acid under green conditions. An exciting feature of this condensation is that the product structure is determined by the catalyst used. The reaction features easy workup, excellent yields, and the use of water as green solvent.

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ACKNOWLEDGMENTS

The authors are grateful to the management of Dr. Reddy’s Laboratories Ltd. for supporting this work and highly appreciate the co-operation from all the supporting colleagues at Dr. Reddy’s Laboratories Private Limited.

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Authors and Affiliations

  1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, 533502, Green Fields, Vaddeswaram, Guntur, Andhra Pradesh, India

    V. Hari Krishna Reddy & A. Venkateswara Rao

  2. API R&D, IPDO, Dr. Reddy’s Laboratories Ltd., 500090, Bachupally, Hyderabad, Telangana, India

    V. Hari Krishna Reddy

Authors
  1. V. Hari Krishna Reddy
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  2. A. Venkateswara Rao
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Correspondence to V. Hari Krishna Reddy.

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Reddy, V.H.K., Rao, A.V. Unexpected Formation of Indolylmethylene Bis-Meldrum’s Acid Derivatives under Green Conditions. Russ J Org Chem 58, 1348–1353 (2022). https://doi.org/10.1134/S1070428022090226

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  • DOI: https://doi.org/10.1134/S1070428022090226

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