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Synthesis of New Heterocyclic Systems Based on 2-Imino-2,5-dihydrofuran-3-carboxamides

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Abstract

2-Imino-2,5-dihydrofuran-3-carboxamides reacted with salicylaldehyde in the presence of piperi­dine in pentan-1-ol to give new fused heterocycles, 2-(2-hydroxyphenyl)-5-[2-(2-hydroxyphenyl)ethylidene]-5,6-dihydrofuro[2,3-d]pyrimidine-4(3H)-ones, which were alkylated with benzyl chloride in the presence of potassium carbonate in dimethylformamide to afford the corresponding O-benzyl derivatives in high yields. The synthesized compounds were characterized by NMR spectra and elemental analyses.

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ACKNOWLEDGMENTS

The authors thank the staff of the Molecular Structure Research Center (Yerevan, Armenia) for recording the NMR spectra and performing elemental analyses.

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Authors and Affiliations

  1. Yerevan State University, 0025, Yerevan, Armenia

    L. V. Karapetyan & G. G. Tokmajyan

Authors
  1. L. V. Karapetyan
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  2. G. G. Tokmajyan
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Correspondence to L. V. Karapetyan.

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Translated from Zhurnal Organicheskoi Khimii, 2022, Vol. 58, No. 9, pp. 994–999 https://doi.org/10.31857/S0514749222090087.

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Karapetyan, L.V., Tokmajyan, G.G. Synthesis of New Heterocyclic Systems Based on 2-Imino-2,5-dihydrofuran-3-carboxamides. Russ J Org Chem 58, 1250–1253 (2022). https://doi.org/10.1134/S1070428022090081

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