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Synthesis, Spectral Characterization, and Antimicrobial Evaluation of N,N′-(1,4-Phenylene)diurea Derivatives

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Abstract

A series of new 1,1′-(1,4-phenylene)diurea derivatives were synthesized by reacting 1,4-diiso­cyanato­benzene with various biologically relevant primary and secondary amines with high yields. The struc­tures of the synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectra and elemental analyses. Most of the synthesized compounds showed good activities against some bacterial and fungal strains.

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Authors and Affiliations

  1. Department of Chemistry, S. G. Govt. Degree & PG College, Piler, Sri Venkateswara University, 517502, Tirupati, Andhra Pradesh, India

    K. Pushpakumar & D. Venkataramana Reddy

  2. Centre for Applied Sciences, Sree Vidyanikethan Engineering College, A. Rangampet, 517102, Tirupati, Andhra Pradesh, India

    M. Varalakshmi & A. Uma Ravi Sankar

  3. Department of Science and Humanities, Sri Venkateswara Engineering College, 517507, Tirupati, Andhra Pradesh, India

    Reddi Mohan Naidu

  4. Department of Biochemistry, Sri Venkateswara University, 517502, Tirupati, Andhra Pradesh, India

    K. Umamahesh

  5. Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, Andhra Pradesh, India

    C. Naga Raju

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  1. K. Pushpakumar
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  2. M. Varalakshmi
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  3. A. Uma Ravi Sankar
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Correspondence to C. Naga Raju.

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Pushpakumar, K., Varalakshmi, M., Sankar, A.U.R. et al. Synthesis, Spectral Characterization, and Antimicrobial Evaluation of N,N′-(1,4-Phenylene)diurea Derivatives. Russ J Org Chem 58, 612–618 (2022). https://doi.org/10.1134/S1070428022040212

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  • DOI: https://doi.org/10.1134/S1070428022040212

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