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Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives

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Abstract

Four pyranopyrimidinedione derivatives were prepared through a one-pot pseudo-three-component acetic acid-catalyzed reaction of 6-amino-1,3-dimethyluracil with 2-hydroxybenzaldehydes. The synthesized compounds were evaluated for their antibacterial activity against a panel of bacterial strains. The minimum inhibitory concentrations (MICs) were determined using broth microdilution assay according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. With the exception of 5-methoxy derivative, the other pyranopyrimidinediones exhibited antibacterial activities against all tested bacterial cultures. The most potent antibacterial effect was observed for 5-bromopyranopyrimidinedione derivative against clinical strains, which can be regarded as promising.

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Funding

The financial support from Alzahra University is grate­fully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Vanak, 19938-91176, Tehran, Iran

    Z. Azarkamanzad & F. Farzaneh

  2. School of Chemistry, College of Science, University of Tehran, 14155-6455, Tehran, Iran

    M. Ghandi

  3. School of Medicine, Tehran University of Medical Sciences, 19938-91176, Tehran, Iran

    M. M. Feizabadi & S. Jasemi

Authors
  1. Z. Azarkamanzad
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  2. F. Farzaneh
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  3. M. Ghandi
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  4. M. M. Feizabadi
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  5. S. Jasemi
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Corresponding author

Correspondence to F. Farzaneh.

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Azarkamanzad, Z., Farzaneh, F., Ghandi, M. et al. Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives. Russ J Org Chem 58, 372–378 (2022). https://doi.org/10.1134/S1070428022030162

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  • DOI: https://doi.org/10.1134/S1070428022030162

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