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Convenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives

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Abstract

A simple and efficient method for derivatization of the pyrimidine nucleus is developed. The readily available 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one has been used as a versatile building block for the synthesis of thioxopyrimidine derivatives. A variety of novel fused pyrimidines has been prepared via nucleophilic and/or electrophilic reactions of thioxopyrimidine derivatives. The structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Education, Ain Shams University, 11711, Cairo, Egypt

    K. M. El-Mahdy & O. Farouk

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  1. K. M. El-Mahdy
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  2. O. Farouk
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Correspondence to K. M. El-Mahdy.

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El-Mahdy, K.M., Farouk, O. Convenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives. Russ J Org Chem 56, 2022–2027 (2020). https://doi.org/10.1134/S1070428020110172

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  • DOI: https://doi.org/10.1134/S1070428020110172

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