Abstract
A convenient one-pot, three-component, and solvent-free procedure for the preparation of substituted (E)-1-phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones, which has made a significant improvement of previously reported methods, has been developed. The reaction of chloro aldehydes, ketones, and piperidine under microwave irradiation afforded the corresponding piperidine-substituted chalcone derivatives in high yields in shorter reaction times. All the synthesized compounds were characterized by IR and 1H and 13C NMR spectroscopy, and mass spectroscopy.
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The authors are grateful to the Department of Chemistry, CMR Institute of Technology and Department of Chemistry, ICFAI Foundation for Higher Education, Hyderabad, India for providing laboratory facilities.
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A One-Pot, Solvent-Free, and Catalyst-Free Synthesis of Substituted (E)-1-Phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones Under Microwave Irradiation
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Pujari, V.K., Vinnakota, S., Kakarla, R.K. et al. A One-Pot, Solvent-Free, and Catalyst-Free Synthesis of Substituted (E)-1-Phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones Under Microwave Irradiation. Russ J Org Chem 55, 1772–1776 (2019). https://doi.org/10.1134/S1070428019110204
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DOI: https://doi.org/10.1134/S1070428019110204