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Synthesis of γ-(Arylamino)butyric Acid Derivatives via Ring-Opening Addition of Arylamines to Cyclopropane-1,1-Dicarboxylates

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Abstract

A rapid and efficient catalytic approach has been proposed for the synthesis of dimethyl 2-[2-(aryl-amino)but-3-en-1-yl]- and 2-[2-(arylamino)-2-phenylethyl]malonates in good yields (49-95%) by ring-opening reaction of dimethyl 2-vinyl- and 2-phenylcyclopropane-1,1-dicarboxylates with arylamines in the presence of Yb(III) catalyst under microwave irradiation. The synthesized compounds are convenient precursors to γ-(aryl-amino)butyric acid derivatives.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 201620, Shanghai, China

    S. K. Li, L. L. Huang, Y. D. Lv & H. D. Feng

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  1. S. K. Li
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  2. L. L. Huang
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  3. Y. D. Lv
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Correspondence to L. L. Huang.

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Li, S.K., Huang, L.L., Lv, Y.D. et al. Synthesis of γ-(Arylamino)butyric Acid Derivatives via Ring-Opening Addition of Arylamines to Cyclopropane-1,1-Dicarboxylates. Russ J Org Chem 55, 1432–1438 (2019). https://doi.org/10.1134/S1070428019090252

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