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Russian Journal of Organic Chemistry

, Volume 55, Issue 5, pp 598–601 | Cite as

Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene

  • S. O. Vardanyan
  • A. A. Aghekyan
  • A. S. AvagyanEmail author
  • S. A. Harutyunyan
  • H. V. Gasparyan
Article
  • 22 Downloads

Abstract

thyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate was synthesized by the Gewald reaction of 2-acetyl-1,4-benzodioxane with ethyl 2-cyanoacetate and sulfur in the presence of diethylamine. The product was used to synthesize a series of amido ester derivatives with various pharmacophoric fragments. The antihypoxic properties of the synthesized amido esters were investigated.

Keywords

2-acetyl-1,4-benzodioxane thiophene ethyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate amido ester antihypoxic activity 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • S. O. Vardanyan
    • 1
  • A. A. Aghekyan
    • 1
  • A. S. Avagyan
    • 1
    Email author
  • S. A. Harutyunyan
    • 1
  • H. V. Gasparyan
    • 1
  1. 1.Scientific Technological Centre of Organic and Pharmaceutical ChemistryNational Academy of Sciences of the Republic of ArmeniaYerevanArmenia

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