Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene
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thyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate was synthesized by the Gewald reaction of 2-acetyl-1,4-benzodioxane with ethyl 2-cyanoacetate and sulfur in the presence of diethylamine. The product was used to synthesize a series of amido ester derivatives with various pharmacophoric fragments. The antihypoxic properties of the synthesized amido esters were investigated.
Keywords2-acetyl-1,4-benzodioxane thiophene ethyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate amido ester antihypoxic activity
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