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Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene

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Abstract

thyl 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylate was synthesized by the Gewald reaction of 2-acetyl-1,4-benzodioxane with ethyl 2-cyanoacetate and sulfur in the presence of diethylamine. The product was used to synthesize a series of amido ester derivatives with various pharmacophoric fragments. The antihypoxic properties of the synthesized amido esters were investigated.

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Authors and Affiliations

  1. Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, ul. Azatutyan 26, Yerevan, 0014, Armenia

    S. O. Vardanyan, A. A. Aghekyan, A. S. Avagyan, S. A. Harutyunyan & H. V. Gasparyan

Authors
  1. S. O. Vardanyan
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  2. A. A. Aghekyan
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  3. A. S. Avagyan
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  4. S. A. Harutyunyan
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  5. H. V. Gasparyan
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Corresponding author

Correspondence to A. S. Avagyan.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 5, pp. 690–693.

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Vardanyan, S.O., Aghekyan, A.A., Avagyan, A.S. et al. Synthesis of New Derivatives of 4-(1,4-Benzodioxan-2-yl)thiophene. Russ J Org Chem 55, 598–601 (2019). https://doi.org/10.1134/S1070428019050038

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  • DOI: https://doi.org/10.1134/S1070428019050038

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