Abstract
Optically active derivatives of 3,4-dihydropyrimidin-2(1H)-one have been synthesized on the basis of myrtenal and methyl 2,3-O-isopropylidene-α-L-erythro-pentodialdo-1,4-furanoside in 45 and 50% yields, respectively, and subjected to stereoselective chlorination with chlorine dioxide, which afforded a series of mono-, di-, and trichloro derivatives in up to 98% yield.
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Original Russian Text © E.S. Izmest’ev, S.V. Pestova, S.A. Rubtsova, A.V. Kutchin, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 9, pp. 1380–1385.
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Izmest’ev, E.S., Pestova, S.V., Rubtsova, S.A. et al. Synthesis of Chiral 3,4-Dihydropyrimidin-2(1H)-one Derivatives and Their Stereoselective Chlorination with Chlorine Dioxide. Russ J Org Chem 54, 1395–1401 (2018). https://doi.org/10.1134/S107042801809021X
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DOI: https://doi.org/10.1134/S107042801809021X