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Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids

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Abstract

ω-[(4Z)-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4H)-imidazol-5-one derivatives based thereon were tested for anticholinesterase activity.

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References

  1. Sadula, A., Peddabiona, U.R., and Subhashini, P.N., J. Med. Chem. Res., 2015, vol. 24, p.851.

    Article  CAS  Google Scholar 

  2. Voosala, C., Yaria, N.S., Nakka, M.R., and Vidavaluri, S., Med. Chem., 2013, vol. 4, p.303.

    Article  CAS  Google Scholar 

  3. Solankee, A., Patel, G., and Patel, K., Indian J. Chem., Sect. B, 2011, vol. 50, p.949.

    Google Scholar 

  4. Kaila, V.J., Desai, D.J., Patel, K.D., and Chudasama, C.J., Orient. J. Chem., 2008, vol. 24, p.589.

    CAS  Google Scholar 

  5. Topuzyan, V.O., Oganesyan, A.A., and Panosyan, G.A., Russ. J. Org. Chem., 2004, vol. 40, p. 1644.

    Article  CAS  Google Scholar 

  6. Topuzyan, V.O., Arutyunyan, L.G., and Oganesyan, A.A., Russ. J. Org. Chem., 2007, vol. 43, p.868.

    Article  CAS  Google Scholar 

  7. Topuzyan, V.O., Arutyunyan, L.G., Oganesyan, A.A., and Panosyan, G.A., Russ. J. Org. Chem., 2007, vol. 43, p.936.

    Article  CAS  Google Scholar 

  8. Topuzyan, V.O., Arutyunyan, L.G., Oganesyan, A.A., and Panosyan, G.A., Russ. J. Org. Chem., 2008, vol. 44, p.474.

    Article  CAS  Google Scholar 

  9. Topuzyan, V.O., Kazandzhyan, M.M., Tamazyan, R.A., and Aivazyan, A.G., Russ. J. Org. Chem., 2009, vol. 45, p.215.

    Article  CAS  Google Scholar 

  10. Tosunyan, S.R., Khim. Zh. Arm., 2012, vol. 66, p.316.

    Google Scholar 

  11. Muselli, M., Colombeau, L., Hedouin, J., Hoarau, C., and Bischoff, L., Synlett, 2016, vol. 27, p. 2819.

    Article  CAS  Google Scholar 

  12. Topuzyan, V.O., Akopyan, A.Z., Durgaryan, L.K., Vlasenko, E.V., Paronikyan, R.G., Paronikyan, R.V., and Ter-Zakharyan, Yu.Z., Pharm. Chem. J., 1995, vol. 29, no. 3, p.200.

    Article  Google Scholar 

  13. Sheldrick, G.M., Acta Crystallogr., Sect. C, 2015, vol. 71, p.3.

    Article  CAS  Google Scholar 

  14. Topuzyan, V.O. and Tosunyan, S.R., Khim. Zh. Arm., 2012, vol. 65, p.369.

    CAS  Google Scholar 

  15. Aziz-ur-Rehman, Afroz, S., Abbasi, M.A., Tanveer, W., Khan, K.M., Ashraf, M., Ahmad, I., Afzal, I., and Ambreen, N., Pak. J. Pharm. Sci., 2012, vol. 25, no. 4, p. 809.

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    V. O. Topuzyan, V. M. Kazoyan, R. A. Tamazyan & A. G. Aivazyan

  2. Yerevan State University, ul. Aleka Manukyana 1, Yerevan, 0025, Armenia

    L. Kh. Galstyan

Authors
  1. V. O. Topuzyan
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  2. V. M. Kazoyan
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  3. R. A. Tamazyan
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  4. A. G. Aivazyan
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  5. L. Kh. Galstyan
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Corresponding author

Correspondence to V. O. Topuzyan.

Additional information

Original Russian Text © V.O. Topuzyan, V.M. Kazoyan, R.A. Tamazyan, A.G. Aivazyan, L.Kh. Galstyan, 2018, published in Zhurnal Organicheskoi Khimii, 2018, Vol. 54, No. 9, pp. 1355–1363.

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Topuzyan, V.O., Kazoyan, V.M., Tamazyan, R.A. et al. Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids. Russ J Org Chem 54, 1369–1377 (2018). https://doi.org/10.1134/S1070428018090178

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  • DOI: https://doi.org/10.1134/S1070428018090178

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