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Synthesis and Some Pharmacological Properties of N-Benzoyl-α,β-dehydrotyrosine-Containing Dipeptides

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Abstract

The reaction of 2-phenyl-4-(4-benzoyloxyarylidene)-5(4H)-oxazolones the corresponding amino acids with hydrochlorides of methyl esters afforded N,O-dibenzoyl-α,β-dehydrotyrosylpeptides methyl esters. From the latter, O-benzoyl protecting group was removed with 3-(dimethylamino)-1-propylamine. Antiradical and anticholinesterase activity of the synthesized α,β-dehydrotyrosylpeptides were studied.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    A. A. Hovhannisyan & A. T. Makichyan

  2. Russian-Armenian University, 0051, Yerevan, Armenia

    A. T. Makichyan & L. S. Hunanyan

Authors
  1. V. O. Topuzyan
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  2. A. A. Hovhannisyan
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  3. A. T. Makichyan
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  4. L. S. Hunanyan
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Correspondence to A. T. Makichyan.

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Topuzyan, V.O., Hovhannisyan, A.A., Makichyan, A.T. et al. Synthesis and Some Pharmacological Properties of N-Benzoyl-α,β-dehydrotyrosine-Containing Dipeptides. Russ J Gen Chem 92, 819–831 (2022). https://doi.org/10.1134/S1070363222050115

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