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First catalyst- and solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones

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Abstract

A completely green and environmentally benign Biginelli synthesis of 3,4-dihydropyrimidine-2(1H)-ones and -thiones by one-pot three-component reaction of aromatic aldehydes with ethyl acetoacetate and urea or thiourea without any catalyst under solvent-free conditions is described.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Ilam University, P.O. Box 69315516, Ilam, Iran

    M. Hajjami & E. Ghiasbeygi

Authors
  1. M. Hajjami
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  2. E. Ghiasbeygi
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Correspondence to M. Hajjami.

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Hajjami, M., Ghiasbeygi, E. First catalyst- and solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones. Russ J Org Chem 52, 429–432 (2016). https://doi.org/10.1134/S1070428016030222

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  • DOI: https://doi.org/10.1134/S1070428016030222

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