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Reaction of unsymmetrical α,β-unsaturated ketones with thiobarbituric acid

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Abstract

Carbocyclization of unsymmetrical 1,5-diarylpenta-1,4-dien-3-ones with thiobarbituric acid afforded previously unknown 7,11-diaryl-3-thioxo-2,4-diazaspiro[5.5]undecane-1,5,9-triones with high regio- and stereoselectivity. The same spiro compounds were also synthesized by three-component condensation of thiobarbituric acid with the corresponding aromatic aldehydes and 4-arylbut-3-en-2-ones.

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Authors and Affiliations

  1. Chernyshevsky Saratov State University, ul. Astrakhanskaya 83, Saratov, 410012, Russia

    I. N. Klochkova, A. A. Anis’kov, M. P. Shchekina, S. V. Chuvaikina & K. A. Andreev

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  1. I. N. Klochkova
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  2. A. A. Anis’kov
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  3. M. P. Shchekina
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  4. S. V. Chuvaikina
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  5. K. A. Andreev
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Correspondence to A. A. Anis’kov.

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Original Russian Text © I.N. Klochkova, A.A. Anis’kov, M.P. Shchekina, S.V. Chuvaikina, K.A. Andreev, 2013, published in Zhurnal Organicheskoi Khimii, 2013, Vol. 49, No. 9, pp. 1359–1362.

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Klochkova, I.N., Anis’kov, A.A., Shchekina, M.P. et al. Reaction of unsymmetrical α,β-unsaturated ketones with thiobarbituric acid. Russ J Org Chem 49, 1344–1347 (2013). https://doi.org/10.1134/S1070428013090169

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  • DOI: https://doi.org/10.1134/S1070428013090169

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