Abstract
The condensation of ethyl acetoacetate with formaldehyde and primary amines in methanol at 65°C (Mannich reaction) gave up to 92% of hexahydropyrimidine derivatives containing ester and acetyl groups. Analogous reaction with aminopyridines stopped at the stage of formation of linear condensation products.
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Original Russian Text © D.R. Latypova, A.G. Badamshin, A.N. Lobov, V.A. Dokichev, 2013, published in Zhurnal Organicheskoi Khimii, 2013, Vol. 49, No. 6, pp. 860–865.
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Latypova, D.R., Badamshin, A.G., Lobov, A.N. et al. Reaction of ethyl acetoacetate with formaldehyde and primary amines. Russ J Org Chem 49, 843–848 (2013). https://doi.org/10.1134/S1070428013060079
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DOI: https://doi.org/10.1134/S1070428013060079