Abstract
Reductive methylation of primary or secondary amines using formaldehyde and formic acid. Cf. Leuckart–Wallach reaction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
(a) Eschweiler, W. Chem. Ber. 1905, 38, 880–892. Wilhelm Eschweiler (1860–1936) was born in Euskirchen, Germany. (b) Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. J. Am. Chem. Soc. 1933, 55, 4571–4587. Hans T. Clarke (1887–1927) was born in Harrow, England.
Moore, M. L. Org. React. 1949, 5, 301–330. (Review).
Pine, S. H.; Sanchez, B. L. J. Org. Chem. 1971, 36, 829–832.
Bobowski, G. J. Org. Chem. 1985, 50, 929–931.
Alder, R. W.; Colclough, D.; Mowlam, R. W. Tetrahedron Lett. 1991, 32, 7755–7758.
Bulman Page, P. C.; Heaney, H.; Rassias, G. A.; Reignier, S.; Sampler, E. P.; Talib, S. Synlett 2000, 104–106.
Harding, J. R.; Jones, J. R.; Lu, S.-Y.; Wood, R. Tetrahedron Lett. 2002, 43, 9487– 9488.
Brewer, A. R. E. Eschweiler–Clarke Reductive Alkylation of Amine. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 86–111. (Review).
Weis, R.; Faist, J.; di Vora, U.; Schweiger, K.; Brandner, B.; Kungl, A. J.; Seebacher, W. Eur. J. Med. Chem. 2008, 43, 872–879.
Waterman, K. C.; Arikpo, W. B.; Fergione, M. B.; Graul, T. W.; Johnson, B. A.; Macdonald, B. C.; Roy, M. C.; Timpano, R. J. J. Pharm. Sci. 2008, 97, 1499–1507.
Sasikumar, M.; Nikalje, Milind D. Synth. Commun. 2012, 42, 3061–3067.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Li, J.J. (2014). Eschweiler–Clarke reductive alkylation of amines. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_98
Download citation
DOI: https://doi.org/10.1007/978-3-319-03979-4_98
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-03978-7
Online ISBN: 978-3-319-03979-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)