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Synthesis of maleopimaric and citraconopimaric acids N-[3-(pyrimidin-2-yl)aryl]amides

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Abstract

Acylation of 6-methyl-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, 4-methyl-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, and N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine with maleopimaric and citraconopimaric acid chlorides, with benzotriazolyl maleopimarate afforded N-[3-(pyrimidin-2-yl)aryl]amides of maleopimaric and citraconopimaric acids. By the reaction of substituted N-arylamides of maleopimaric acid with methanesulfonic acid biologically active methanesulfonates were obtained.

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Authors and Affiliations

  1. Institute of New Materials Chemistry of National Academy of Belarus, Academy of Sciences of Belarus, Minsk, 220141, Belarus’

    E. V. Koroleva, K. N. Gusak, Zh. V. Ignatovich, A. L. Ermolinskaya, M. P. Bei & A. P. Yuvchenko

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  1. E. V. Koroleva
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  2. K. N. Gusak
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  3. Zh. V. Ignatovich
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  4. A. L. Ermolinskaya
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  5. M. P. Bei
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  6. A. P. Yuvchenko
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Correspondence to E. V. Koroleva.

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Original English Text © E.V. Koroleva, K.N. Gusak, Zh.V. Ignatovich, A.L. Ermolinskaya, M.P. Bei, A.P. Yuvchenko, 2012, published in Zhurnal Organicheskoi Khimii, 2012, Vol. 48, No. 8, pp. 1122–1126.

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Koroleva, E.V., Gusak, K.N., Ignatovich, Z.V. et al. Synthesis of maleopimaric and citraconopimaric acids N-[3-(pyrimidin-2-yl)aryl]amides. Russ J Org Chem 48, 1121–1125 (2012). https://doi.org/10.1134/S1070428012080143

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  • DOI: https://doi.org/10.1134/S1070428012080143

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