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Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones

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Abstract

Regioselectivity was examined of reactions between nine 3(5)-aminopyrazoles and 2-acetylcyclopentanone and 2-acetylcyclohexanone under various conditions. A series of cyclopenta[e]pyrazolo-[1,5-a]pyrimidines was obtained. The highest regioselectivity of the reaction was observed in alcohol at 20°C in the presence of a catalytic quantity of trifl uoroacetic acid. The regiostructure of compounds was established by 1H and 13C NMR spectroscopy.

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Authors and Affiliations

  1. St. Petersburg State University, St. Petersburg, 198504, Russia

    A. A. Petrov, A. N. Kasatochkin & E. E. Emelina

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  1. A. A. Petrov
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  2. A. N. Kasatochkin
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  3. E. E. Emelina
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Correspondence to A. A. Petrov.

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Original English Text © A.A. Petrov, A.N. Kasatochkin, E.E. Emelina, 2012, published in Zhurnal Organicheskoi Khimii, 2012, Vol. 48, No. 8, pp. 1113–1121.

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Petrov, A.A., Kasatochkin, A.N. & Emelina, E.E. Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones. Russ J Org Chem 48, 1111–1120 (2012). https://doi.org/10.1134/S1070428012080131

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  • DOI: https://doi.org/10.1134/S1070428012080131

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