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Microwave-assisted synthesis and antifungal activity of some new 1H-1,2,4-triazole derivatives

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Abstract

A number of 3-aryl-4-arylmethylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized by reaction of the corresponding aromatic aldehydes with 4-amino-3-aryl-1H-1,2,4-triazol-5-ones in anhydrous ethanol under microwave irradiation. The newly synthesized 1H-1,2,4-triazole derivatives were tested for antimicrobial activity. They showed no antibacterial activity but slight mycostatic activity against some Candida species.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Arts and Sciences, Rize University, Rize, 53050, Turkey

    B. Kahveci, M. Özil & E. Menteşe

  2. Chemistry Department, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey

    O. Bekircan

  3. Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, 61080, Turkey

    K. Buruk

Authors
  1. B. Kahveci
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  2. M. Özil
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  3. E. Menteşe
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  4. O. Bekircan
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  5. K. Buruk
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Corresponding author

Correspondence to B. Kahveci.

Additional information

Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 12, pp. 1843–1847.

The text was submitted by the authors in English.

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Kahveci, B., Özil, M., Menteşe, E. et al. Microwave-assisted synthesis and antifungal activity of some new 1H-1,2,4-triazole derivatives. Russ J Org Chem 44, 1816–1820 (2008). https://doi.org/10.1134/S1070428008120178

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  • DOI: https://doi.org/10.1134/S1070428008120178

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