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Synthesis of 5-substituted 3-(2-oxopropyl)tetrahydrofuran-2-ones and heterocyclic compounds on their base

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Abstract

Alkylation of ethyl 2-oxotetrahydrofuran-3-carboxylates with 2,3-dichloroprop-1-ene and 3-bromoprop-1-yne gave new 3,5,5-tri- and 3,3,5,5-tetrasubstituted tetrahydrofuran-2-ones which were converted into the corresponding 3-(2-oxopropyl)tetrahydrofuran-2-ones. Reactions of the latter with semicarabazide, thiosemicarbazide, and phenylhydrazine were studied with a view to obtain new heterocyclic lactones.

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Authors and Affiliations

  1. Erevan State University, ul. Aleka Manukyana 1, Erevan, 375025, Armenia

    T. V. Kochikyan, E. V. Arutyunyan, V. S. Arutyunyan & A. A. Avetisyan

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  1. T. V. Kochikyan
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  2. E. V. Arutyunyan
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  3. V. S. Arutyunyan
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  4. A. A. Avetisyan
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Correspondence to T. V. Kochikyan.

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Original Russian Text © T.V. Kochikyan, E.V. Arutyunyan, V.S. Arutyunyan, A.A. Avetisyan, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 12, pp. 1826–1830.

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Kochikyan, T.V., Arutyunyan, E.V., Arutyunyan, V.S. et al. Synthesis of 5-substituted 3-(2-oxopropyl)tetrahydrofuran-2-ones and heterocyclic compounds on their base. Russ J Org Chem 44, 1799–1803 (2008). https://doi.org/10.1134/S1070428008120130

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  • DOI: https://doi.org/10.1134/S1070428008120130

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