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New 1,3,4-thiadiazole derivatives from 1-benzylidenethiocarbonohydrazides and 3-Bromo-1-phenylprop-2-yn-1-one

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Abstract

3-Bromo-1-phenylprop-2-yn-1-one reacted with 1-benzylidenethiocarbonohydrazones in acetic acid or acetonitrile at room temperature (reaction time 3 h) to give in good yields the corresponding benzaldehyde N′-(5-benzoylmethyl-1,3,4-thiadiazol-2-yl)hydrazone hydrobromides which were converted into the free bases by treatment with aqueous ammonia.

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Authors and Affiliations

  1. Favorskii Irkutsk Institute of Chemistry, Siberian Division, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia

    T. E. Glotova, M. Yu. Dvorko, V. G. Samoilov & I. A. Ushakov

Authors
  1. T. E. Glotova
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  2. M. Yu. Dvorko
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  3. V. G. Samoilov
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  4. I. A. Ushakov
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Correspondence to T. E. Glotova.

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Original Russian Text © T.E. Glotova, M.Yu. Dvorko, V.G. Samoilov, I.A. Ushakov, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 6, pp. 875–878.

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Glotova, T.E., Dvorko, M.Y., Samoilov, V.G. et al. New 1,3,4-thiadiazole derivatives from 1-benzylidenethiocarbonohydrazides and 3-Bromo-1-phenylprop-2-yn-1-one. Russ J Org Chem 44, 866–869 (2008). https://doi.org/10.1134/S1070428008060158

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  • DOI: https://doi.org/10.1134/S1070428008060158

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