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Development and Characterization of Copper Nanoparticles Embedded Polymeric Microbeads for Drug Delivery and Antibacterial Applications

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Abstract

Nanoparticles have been utilized in a variety of biomedical applications owing to their ability to achieve systemic stability and targeted drug delivery. In the present work, a new form of nanoparticle-embedded polymeric microbeads has been developed for controlled drug delivery applications. Copper nanoparticles are synthesized using copper sulfate pentahydrate via chemical reduction method. Using gelation technique microbeads are synthesized by combining copper nanoparticles with sodium alginate/badam gum polymeric matrix. The generated microbeads were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transition electron microscopy (TEM), selected area electron diffraction (SAED), and scanning electron microscopy (SEM). Ofloxacin used as model bioactive agent and studied the release and swelling studies at pH 2.0 and 7.4 at 37°C. Upon loading OFLX in to microbeads antibacterial activity were tested against S. mutans, K. pneumonia, and B. subtilis. The release kinetics and mechanism was analyzed by fitting the release data into different kinetic models and Korsmeyer–Peppas equation.

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Authors and Affiliations

  1. Department of Chemistry, Telangana University, Nizamabad, 503322, Telangana, India

    E. Venkata Ramana

  2. Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, 503322, Telangana, India

    Naseem

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  1. E. Venkata Ramana
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  2. Naseem
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Ramana, E.V., Naseem Development and Characterization of Copper Nanoparticles Embedded Polymeric Microbeads for Drug Delivery and Antibacterial Applications. Russ J Appl Chem 95, 1459–1466 (2022). https://doi.org/10.1134/S1070427222090221

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  • DOI: https://doi.org/10.1134/S1070427222090221

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